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Transmission dynamics of SARS-CoV-2 in a mid-size city of China.
BMC Infect Dis. 2021 Aug 10; 21(1):793.BI

Abstract

BACKGROUND

An outbreak of pneumonia, COVID-19 associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city and then rapidly spread to other cities. Wenzhou is located approximately 900 km from Wuhan, which was experiencing an outbreak that was severe at the time but is considered modest as the epidemic became a pandemic. We described the epidemiological characteristics of SARS-CoV-2 outside of the epicenter to help understand the transmission pattern in a mid-sized Chinese city.

METHODS

To investigate the epidemiological and clinical characteristics of the COVID-19, we described case series of 473 patients with confirmed COVID-19 in Wenzhou, China from January 27 to March 16, 2020. We described the public health interventions of COVID-19 and evaluated the effect of interventions by the effective reproduction number (Rt).

RESULTS

The median age of all patients was 47.6 years, 48.4% of whom were female. 33.8% of the patients had a history of residence in Wuhan. Fever (71.7%) and cough (43.1%) were the most common symptoms. In addition, three kinds of unconventional cases were observed, namely 4.9% asymptomatic patients, 7.6% confirmed patients who had no link to Wuhan city but contact with individuals from Wuhan without any symptoms at the time of contact, and 12.9% confirmed patients who had an unknown source of transmission. We estimated that the basic reproductive number (R0) was 2.75 (95% CI: 2.37-3.23). The Rt fluctuated within the range of 2.50 to 3.74 from January 11 to January 16 while gradually reached a peak of 3.74 on January 16. Rt gradually decreased after January 16 and decreased to 1.00 on January 30. Rt continually decreased and reached the lowest point (0.03) on February 21, 2020.

CONCLUSION

Our study presented the possibility of asymptomatic carriers affected with SARS-CoV-2, and transmission by these three kinds of unconventional patients in Wenzhou may be an important characteristic of SARS-CoV-2 transmission. The evaluation showed that a series of multifaceted interventions proved effective in controlling the epidemic of COVID-19. These findings might provide valuable examples of control policies for countries or areas in combatting the global pandemic of COVID-19.

Authors+Show Affiliations

State Key Lab of Respiratory Disease, The First Affiliated Hospital, Institute for Public Health, School of Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, China.Department of English and American Studies, Faculty of Languages and Literatures, Ludwig Maximilian University (LMU), Munich, Germany.State Key Lab of Respiratory Disease, The First Affiliated Hospital, Institute for Public Health, School of Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, China.Department of Epidemiology, Guangzhou Chest Hospital, No. 62 Hengzhigang Road, Guangzhou, 510095, China.State Key Lab of Respiratory Disease, The First Affiliated Hospital, Institute for Public Health, School of Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, China.Guangzhou Centre for Disease Control and Prevention, No. 1 Qide Road, Guangzhou, 510440, China.Guangzhou Centre for Disease Control and Prevention, No. 1 Qide Road, Guangzhou, 510440, China.State Key Lab of Respiratory Disease, The First Affiliated Hospital, Institute for Public Health, School of Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, China.Guangzhou Centre for Disease Control and Prevention, No. 1 Qide Road, Guangzhou, 510440, China.State Key Lab of Respiratory Disease, The First Affiliated Hospital, Institute for Public Health, School of Public Health, Guangzhou Medical University, 195 Dongfengxi Road, Guangzhou, 510182, China. jclu@gzhmu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34376168

Citation

Zhao, Hongjun, et al. "Transmission Dynamics of SARS-CoV-2 in a Mid-size City of China." BMC Infectious Diseases, vol. 21, no. 1, 2021, p. 793.
Zhao H, Lu X, Lun W, et al. Transmission dynamics of SARS-CoV-2 in a mid-size city of China. BMC Infect Dis. 2021;21(1):793.
Zhao, H., Lu, X., Lun, W., Li, T., Rao, B., Wang, D., Wu, D., Qiu, F., Yang, Z., & Lu, J. (2021). Transmission dynamics of SARS-CoV-2 in a mid-size city of China. BMC Infectious Diseases, 21(1), 793. https://doi.org/10.1186/s12879-021-06522-9
Zhao H, et al. Transmission Dynamics of SARS-CoV-2 in a Mid-size City of China. BMC Infect Dis. 2021 Aug 10;21(1):793. PubMed PMID: 34376168.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transmission dynamics of SARS-CoV-2 in a mid-size city of China. AU - Zhao,Hongjun, AU - Lu,Xiaoxiao, AU - Lun,Wenhui, AU - Li,Tiegang, AU - Rao,Boqi, AU - Wang,Dedong, AU - Wu,Di, AU - Qiu,Fuman, AU - Yang,Zhicong, AU - Lu,Jiachun, Y1 - 2021/08/10/ PY - 2020/08/20/received PY - 2021/08/03/accepted PY - 2021/8/11/entrez PY - 2021/8/12/pubmed PY - 2021/9/25/medline KW - Asymptomatic patient KW - COVID-19 KW - Prevention and control measures KW - R0 KW - Rt KW - SARS-CoV-2 KW - Transmission dynamics SP - 793 EP - 793 JF - BMC infectious diseases JO - BMC Infect Dis VL - 21 IS - 1 N2 - BACKGROUND: An outbreak of pneumonia, COVID-19 associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan city and then rapidly spread to other cities. Wenzhou is located approximately 900 km from Wuhan, which was experiencing an outbreak that was severe at the time but is considered modest as the epidemic became a pandemic. We described the epidemiological characteristics of SARS-CoV-2 outside of the epicenter to help understand the transmission pattern in a mid-sized Chinese city. METHODS: To investigate the epidemiological and clinical characteristics of the COVID-19, we described case series of 473 patients with confirmed COVID-19 in Wenzhou, China from January 27 to March 16, 2020. We described the public health interventions of COVID-19 and evaluated the effect of interventions by the effective reproduction number (Rt). RESULTS: The median age of all patients was 47.6 years, 48.4% of whom were female. 33.8% of the patients had a history of residence in Wuhan. Fever (71.7%) and cough (43.1%) were the most common symptoms. In addition, three kinds of unconventional cases were observed, namely 4.9% asymptomatic patients, 7.6% confirmed patients who had no link to Wuhan city but contact with individuals from Wuhan without any symptoms at the time of contact, and 12.9% confirmed patients who had an unknown source of transmission. We estimated that the basic reproductive number (R0) was 2.75 (95% CI: 2.37-3.23). The Rt fluctuated within the range of 2.50 to 3.74 from January 11 to January 16 while gradually reached a peak of 3.74 on January 16. Rt gradually decreased after January 16 and decreased to 1.00 on January 30. Rt continually decreased and reached the lowest point (0.03) on February 21, 2020. CONCLUSION: Our study presented the possibility of asymptomatic carriers affected with SARS-CoV-2, and transmission by these three kinds of unconventional patients in Wenzhou may be an important characteristic of SARS-CoV-2 transmission. The evaluation showed that a series of multifaceted interventions proved effective in controlling the epidemic of COVID-19. These findings might provide valuable examples of control policies for countries or areas in combatting the global pandemic of COVID-19. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/34376168/Transmission_dynamics_of_SARS_CoV_2_in_a_mid_size_city_of_China_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/s12879-021-06522-9 DB - PRIME DP - Unbound Medicine ER -