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A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats.
Lab Anim Sci. 1987 Dec; 37(6):726-30.LA

Abstract

Proper use of anesthetics is of paramount importance for humane animal care. Current research trends show a greater reliance on rats for laboratory investigations. This study compared several dosages for four different drugs, (pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam) for use in the laboratory rat. Each drug was evaluated in respect to its onset, duration of effect, recovery, adverse effects and mortality. A quantitative assessment of the depth of anesthesia also was obtained for all dosages of each drug. Results showed that all tested dosages of pentobarbital, ketamine-xylazine and ketamine-diazepam were suitable anesthetics for use in the laboratory rat. Low dosages of fentanyl-droperidol (Innovar-Vet), however, appeared to produce a state known as neuroleptanalgesia as opposed to anesthesia seen with the other agents.

Authors+Show Affiliations

Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3437748

Citation

Wixson, S K., et al. "A Comparison of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam Anesthesia in Adult Male Rats." Laboratory Animal Science, vol. 37, no. 6, 1987, pp. 726-30.
Wixson SK, White WJ, Hughes HC, et al. A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats. Lab Anim Sci. 1987;37(6):726-30.
Wixson, S. K., White, W. J., Hughes, H. C., Lang, C. M., & Marshall, W. K. (1987). A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats. Laboratory Animal Science, 37(6), 726-30.
Wixson SK, et al. A Comparison of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam Anesthesia in Adult Male Rats. Lab Anim Sci. 1987;37(6):726-30. PubMed PMID: 3437748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A comparison of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam anesthesia in adult male rats. AU - Wixson,S K, AU - White,W J, AU - Hughes,H C,Jr AU - Lang,C M, AU - Marshall,W K, PY - 1987/12/1/pubmed PY - 2001/3/28/medline PY - 1987/12/1/entrez SP - 726 EP - 30 JF - Laboratory animal science JO - Lab Anim Sci VL - 37 IS - 6 N2 - Proper use of anesthetics is of paramount importance for humane animal care. Current research trends show a greater reliance on rats for laboratory investigations. This study compared several dosages for four different drugs, (pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam) for use in the laboratory rat. Each drug was evaluated in respect to its onset, duration of effect, recovery, adverse effects and mortality. A quantitative assessment of the depth of anesthesia also was obtained for all dosages of each drug. Results showed that all tested dosages of pentobarbital, ketamine-xylazine and ketamine-diazepam were suitable anesthetics for use in the laboratory rat. Low dosages of fentanyl-droperidol (Innovar-Vet), however, appeared to produce a state known as neuroleptanalgesia as opposed to anesthesia seen with the other agents. SN - 0023-6764 UR - https://www.unboundmedicine.com/medline/citation/3437748/A_comparison_of_pentobarbital_fentanyl_droperidol_ketamine_xylazine_and_ketamine_diazepam_anesthesia_in_adult_male_rats_ DB - PRIME DP - Unbound Medicine ER -