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The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats.
Lab Anim Sci. 1987 Dec; 37(6):731-5.LA

Abstract

The increased use of rats for laboratory studies has increased the urgency for a better understanding of their perception of painful or noxious stimuli and the means of obtunding such stimuli. Four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam, were evaluated in this study. Unlike previous studies in rodents, this study has quantitated noxious stimulus perception following a temporal sequence of observations. Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital. Results of this study also suggested that a spatial orientation, similar to that present in man, exists within the CNS of rats for receipt of noxious stimulation.

Authors+Show Affiliations

Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3437749

Citation

Wixson, S K., et al. "The Effects of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam On Noxious Stimulus Perception in Adult Male Rats." Laboratory Animal Science, vol. 37, no. 6, 1987, pp. 731-5.
Wixson SK, White WJ, Hughes HC, et al. The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats. Lab Anim Sci. 1987;37(6):731-5.
Wixson, S. K., White, W. J., Hughes, H. C., Marshall, W. K., & Lang, C. M. (1987). The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats. Laboratory Animal Science, 37(6), 731-5.
Wixson SK, et al. The Effects of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam On Noxious Stimulus Perception in Adult Male Rats. Lab Anim Sci. 1987;37(6):731-5. PubMed PMID: 3437749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on noxious stimulus perception in adult male rats. AU - Wixson,S K, AU - White,W J, AU - Hughes,H C,Jr AU - Marshall,W K, AU - Lang,C M, PY - 1987/12/1/pubmed PY - 2001/3/28/medline PY - 1987/12/1/entrez SP - 731 EP - 5 JF - Laboratory animal science JO - Lab Anim Sci VL - 37 IS - 6 N2 - The increased use of rats for laboratory studies has increased the urgency for a better understanding of their perception of painful or noxious stimuli and the means of obtunding such stimuli. Four different injectable drugs, pentobarbital, fentanyl-droperidol (Innovar-Vet), ketamine-xylazine and ketamine-diazepam, were evaluated in this study. Unlike previous studies in rodents, this study has quantitated noxious stimulus perception following a temporal sequence of observations. Results showed the greatest inhibition of noxious stimulus perception with Innovar-Vet, lesser inhibition with ketamine-xylazine and ketamine-diazepam, and the least obtunding of nociception with pentobarbital. Results of this study also suggested that a spatial orientation, similar to that present in man, exists within the CNS of rats for receipt of noxious stimulation. SN - 0023-6764 UR - https://www.unboundmedicine.com/medline/citation/3437749/The_effects_of_pentobarbital_fentanyl_droperidol_ketamine_xylazine_and_ketamine_diazepam_on_noxious_stimulus_perception_in_adult_male_rats_ L2 - https://medlineplus.gov/pain.html DB - PRIME DP - Unbound Medicine ER -