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The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on core and surface body temperature regulation in adult male rats.
Lab Anim Sci. 1987 Dec; 37(6):743-9.LA

Abstract

Many commonly used anesthetics cause hypothermia by inhibiting central and peripheral thermoregulatory mechanisms. Although it is probable that a loss of thermal homeostasis contributes directly to the high mortality frequently reported following anesthesia of laboratory rodents, this adverse effect has been investigated rarely in the past. This study compared the effects of three parenteral anesthetics (pentobarbital, ketamine-xylazine and ketamine-diazepam) and a neuroleptanalgesic (fentanyl-droperidol) on core and surface body temperature regulation in rats. Results showed a profound hypothermia with all dosages of pentobarbital, while ketamine-xylazine and ketamine-diazepam caused a dose-dependent depression in core and surface body temperature. All dosages of fentanyl-droperidol (Innovar-Vet) caused minimal depression in thermoregulation, suggesting that it is the drug which requires the least external thermal support. Results of this study also suggested that inability to compensate for heat loss, particularly from the body core, may profoundly influence anesthetic toxicity and the safety of anesthetic procedures.

Authors+Show Affiliations

Department of Comparative Medicine, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3437750

Citation

Wixson, S K., et al. "The Effects of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam On Core and Surface Body Temperature Regulation in Adult Male Rats." Laboratory Animal Science, vol. 37, no. 6, 1987, pp. 743-9.
Wixson SK, White WJ, Hughes HC, et al. The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on core and surface body temperature regulation in adult male rats. Lab Anim Sci. 1987;37(6):743-9.
Wixson, S. K., White, W. J., Hughes, H. C., Lang, C. M., & Marshall, W. K. (1987). The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on core and surface body temperature regulation in adult male rats. Laboratory Animal Science, 37(6), 743-9.
Wixson SK, et al. The Effects of Pentobarbital, Fentanyl-droperidol, Ketamine-xylazine and Ketamine-diazepam On Core and Surface Body Temperature Regulation in Adult Male Rats. Lab Anim Sci. 1987;37(6):743-9. PubMed PMID: 3437750.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of pentobarbital, fentanyl-droperidol, ketamine-xylazine and ketamine-diazepam on core and surface body temperature regulation in adult male rats. AU - Wixson,S K, AU - White,W J, AU - Hughes,H C,Jr AU - Lang,C M, AU - Marshall,W K, PY - 1987/12/1/pubmed PY - 2001/3/28/medline PY - 1987/12/1/entrez SP - 743 EP - 9 JF - Laboratory animal science JO - Lab Anim Sci VL - 37 IS - 6 N2 - Many commonly used anesthetics cause hypothermia by inhibiting central and peripheral thermoregulatory mechanisms. Although it is probable that a loss of thermal homeostasis contributes directly to the high mortality frequently reported following anesthesia of laboratory rodents, this adverse effect has been investigated rarely in the past. This study compared the effects of three parenteral anesthetics (pentobarbital, ketamine-xylazine and ketamine-diazepam) and a neuroleptanalgesic (fentanyl-droperidol) on core and surface body temperature regulation in rats. Results showed a profound hypothermia with all dosages of pentobarbital, while ketamine-xylazine and ketamine-diazepam caused a dose-dependent depression in core and surface body temperature. All dosages of fentanyl-droperidol (Innovar-Vet) caused minimal depression in thermoregulation, suggesting that it is the drug which requires the least external thermal support. Results of this study also suggested that inability to compensate for heat loss, particularly from the body core, may profoundly influence anesthetic toxicity and the safety of anesthetic procedures. SN - 0023-6764 UR - https://www.unboundmedicine.com/medline/citation/3437750/The_effects_of_pentobarbital_fentanyl_droperidol_ketamine_xylazine_and_ketamine_diazepam_on_core_and_surface_body_temperature_regulation_in_adult_male_rats_ DB - PRIME DP - Unbound Medicine ER -