Tags

Type your tag names separated by a space and hit enter

Risk of sick sinus syndrome in patients diagnosed with atrial fibrillation: A population-based cohort.
J Cardiovasc Electrophysiol. 2021 10; 32(10):2704-2714.JC

Abstract

BACKGROUND

Sinoatrial node dysfunction and atrial fibrillation (AF) frequently coexist and interact with each other, often to initiate and perpetuate each other.

OBJECTIVE

To determine the effect of AF on the incidence and risk of sick sinus syndrome (SSS).

METHODS

The association of incident AF with the development of incident SSS was assessed from 2004 to 2014 in 302 229 SSS- and pacemaker-free subjects aged ≥60 years in the Korea National Health Insurance Service-Senior cohort.

RESULTS

During an observation period of 1 854 800 person-years, incident AF was observed in a total of 12 797 subjects (0.69%/year). The incidence of SSS was 3.4 and 0.2 per 1000 person-years in the propensity score-matched incident AF and no-AF groups, respectively. After adjustment, the significantly increased risk of SSS was observed in the incident AF group, with a hazard ratio (HR) of 13.4 (95% confidence interval [CI]: 8.4-21.4). This finding was consistently observed after censoring for heart failure (HR: 16.0; 95% CI: 9.2-28.0) or heart failure/myocardial infarction (HR: 16.6; 95% CI: 9.3-29.7). Incident AF also was associated with an increased risk of pacemaker implantation related with both SSS (HR: 21.8; 95% CI: 8.7-18.4) and atrioventricular (AV) block (HR: 9.5; 95% CI: 4.9-18.4). These results were consistent regardless of sex and comorbidities.

CONCLUSION

Incident AF was associated with more than 10 times increased risk of SSS in an elderly population regardless of comorbidities. The risk of pacemaker implantations related with both sinus node dysfunction and AV block was increased in the elderly population with incident AF.

Authors+Show Affiliations

Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.Department of Cardiology, CHA Bundang Medical Center, CHA University, Seongnam, Republic of Korea.Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.Division of Cardiology, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34379851

Citation

Yang, Pil-Sung, et al. "Risk of Sick Sinus Syndrome in Patients Diagnosed With Atrial Fibrillation: a Population-based Cohort." Journal of Cardiovascular Electrophysiology, vol. 32, no. 10, 2021, pp. 2704-2714.
Yang PS, Kim D, Jang E, et al. Risk of sick sinus syndrome in patients diagnosed with atrial fibrillation: A population-based cohort. J Cardiovasc Electrophysiol. 2021;32(10):2704-2714.
Yang, P. S., Kim, D., Jang, E., Yu, H. T., Kim, T. H., Sung, J. H., Pak, H. N., Lee, M. H., & Joung, B. (2021). Risk of sick sinus syndrome in patients diagnosed with atrial fibrillation: A population-based cohort. Journal of Cardiovascular Electrophysiology, 32(10), 2704-2714. https://doi.org/10.1111/jce.15202
Yang PS, et al. Risk of Sick Sinus Syndrome in Patients Diagnosed With Atrial Fibrillation: a Population-based Cohort. J Cardiovasc Electrophysiol. 2021;32(10):2704-2714. PubMed PMID: 34379851.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of sick sinus syndrome in patients diagnosed with atrial fibrillation: A population-based cohort. AU - Yang,Pil-Sung, AU - Kim,Daehoon, AU - Jang,Eunsun, AU - Yu,Hee Tae, AU - Kim,Tae-Hoon, AU - Sung,Jung-Hoon, AU - Pak,Hui-Nam, AU - Lee,Moon-Hyoung, AU - Joung,Boyoung, Y1 - 2021/08/16/ PY - 2021/06/25/revised PY - 2021/03/10/received PY - 2021/07/30/accepted PY - 2021/8/12/pubmed PY - 2021/10/21/medline PY - 2021/8/11/entrez KW - atrial fibrillation KW - elderly KW - pacemaker KW - sick sinus syndrome SP - 2704 EP - 2714 JF - Journal of cardiovascular electrophysiology JO - J Cardiovasc Electrophysiol VL - 32 IS - 10 N2 - BACKGROUND: Sinoatrial node dysfunction and atrial fibrillation (AF) frequently coexist and interact with each other, often to initiate and perpetuate each other. OBJECTIVE: To determine the effect of AF on the incidence and risk of sick sinus syndrome (SSS). METHODS: The association of incident AF with the development of incident SSS was assessed from 2004 to 2014 in 302 229 SSS- and pacemaker-free subjects aged ≥60 years in the Korea National Health Insurance Service-Senior cohort. RESULTS: During an observation period of 1 854 800 person-years, incident AF was observed in a total of 12 797 subjects (0.69%/year). The incidence of SSS was 3.4 and 0.2 per 1000 person-years in the propensity score-matched incident AF and no-AF groups, respectively. After adjustment, the significantly increased risk of SSS was observed in the incident AF group, with a hazard ratio (HR) of 13.4 (95% confidence interval [CI]: 8.4-21.4). This finding was consistently observed after censoring for heart failure (HR: 16.0; 95% CI: 9.2-28.0) or heart failure/myocardial infarction (HR: 16.6; 95% CI: 9.3-29.7). Incident AF also was associated with an increased risk of pacemaker implantation related with both SSS (HR: 21.8; 95% CI: 8.7-18.4) and atrioventricular (AV) block (HR: 9.5; 95% CI: 4.9-18.4). These results were consistent regardless of sex and comorbidities. CONCLUSION: Incident AF was associated with more than 10 times increased risk of SSS in an elderly population regardless of comorbidities. The risk of pacemaker implantations related with both sinus node dysfunction and AV block was increased in the elderly population with incident AF. SN - 1540-8167 UR - https://www.unboundmedicine.com/medline/citation/34379851/Risk_of_sick_sinus_syndrome_in_patients_diagnosed_with_atrial_fibrillation:_A_population_based_cohort_ L2 - https://doi.org/10.1111/jce.15202 DB - PRIME DP - Unbound Medicine ER -