Tags

Type your tag names separated by a space and hit enter

Mode of action of neurotensin on the spontaneous and electrically-induced contractions of gastric smooth muscle.
Acta Physiol Pharmacol Bulg. 1987; 13(3):66-74.AP

Abstract

Mechanical activity was recorded from muscle preparations isolated from the guinea-pig stomach. Neurotensin (10(-11) M to 10(-7) M) produced dose-dependent tonic contractions and showed a higher affinity but lower efficiency compared to acetylcholine (ACH). Atropine and tetrodotoxin had no effect on the neurotensin responses. Blockade of prostaglandin (PG) synthesis by indomethacin or cortisone (5 X 10(-6) M) shifted to the right the dose-response curve for neurotensin (NT) and significantly reduced the NT maximum responses. The data suggest the involvement of PG-mechanisms in the myogenic effect of neurotensin. The electrically-induced, atropine-sensitive contractions (5 to 10 Hz, 0.3 to 0.5 ms) of the muscle strips were inhibited by NT (10(-11) M to 10(-9) M). This inhibition was overcome by yohimbine (10(-6) M) or prostaglandin F2a. It is concluded that NT modulates cholinergic neurotransmission in gastric smooth muscle probably via presynaptically located adrenoceptors.

Authors+Show Affiliations

Institute of Physiology, Bulgarian Academy of Sciences.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3439476

Citation

Milenov, K, et al. "Mode of Action of Neurotensin On the Spontaneous and Electrically-induced Contractions of Gastric Smooth Muscle." Acta Physiologica Et Pharmacologica Bulgarica, vol. 13, no. 3, 1987, pp. 66-74.
Milenov K, Rakovska A, Bocheva A, et al. Mode of action of neurotensin on the spontaneous and electrically-induced contractions of gastric smooth muscle. Acta Physiol Pharmacol Bulg. 1987;13(3):66-74.
Milenov, K., Rakovska, A., Bocheva, A., & Vassileva, M. (1987). Mode of action of neurotensin on the spontaneous and electrically-induced contractions of gastric smooth muscle. Acta Physiologica Et Pharmacologica Bulgarica, 13(3), 66-74.
Milenov K, et al. Mode of Action of Neurotensin On the Spontaneous and Electrically-induced Contractions of Gastric Smooth Muscle. Acta Physiol Pharmacol Bulg. 1987;13(3):66-74. PubMed PMID: 3439476.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mode of action of neurotensin on the spontaneous and electrically-induced contractions of gastric smooth muscle. AU - Milenov,K, AU - Rakovska,A, AU - Bocheva,A, AU - Vassileva,M, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 66 EP - 74 JF - Acta physiologica et pharmacologica Bulgarica JO - Acta Physiol Pharmacol Bulg VL - 13 IS - 3 N2 - Mechanical activity was recorded from muscle preparations isolated from the guinea-pig stomach. Neurotensin (10(-11) M to 10(-7) M) produced dose-dependent tonic contractions and showed a higher affinity but lower efficiency compared to acetylcholine (ACH). Atropine and tetrodotoxin had no effect on the neurotensin responses. Blockade of prostaglandin (PG) synthesis by indomethacin or cortisone (5 X 10(-6) M) shifted to the right the dose-response curve for neurotensin (NT) and significantly reduced the NT maximum responses. The data suggest the involvement of PG-mechanisms in the myogenic effect of neurotensin. The electrically-induced, atropine-sensitive contractions (5 to 10 Hz, 0.3 to 0.5 ms) of the muscle strips were inhibited by NT (10(-11) M to 10(-9) M). This inhibition was overcome by yohimbine (10(-6) M) or prostaglandin F2a. It is concluded that NT modulates cholinergic neurotransmission in gastric smooth muscle probably via presynaptically located adrenoceptors. SN - 0323-9950 UR - https://www.unboundmedicine.com/medline/citation/3439476/Mode_of_action_of_neurotensin_on_the_spontaneous_and_electrically_induced_contractions_of_gastric_smooth_muscle_ DB - PRIME DP - Unbound Medicine ER -