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Release Kinetics of Hydroxypropyl Methylcellulose Governing Drug Release and Hydrodynamic Changes of Matrix Tablet.
Curr Drug Deliv. 2022; 19(5):520-533.CD

Abstract

BACKGROUND

Hydrophilic Hydroxypropyl Methylcellulose (HPMC) matrix tablets are the standard role model of the oral controlled-release formulation. Nevertheless, the HPMC kinetics for the mechanistic understanding of drug release and hydrodynamic behaviors are rarely investigated. This study aims to investigate the release behaviors of both HPMC and paracetamol (model drug) from the hydrophilic matrix tablet.

METHODS

Two different viscosity grades of HPMC were used (Low viscosity: 6 cps, High viscosity: 4,000 cps). Three different ratios of drug/HPMC (H:38.08%, M:22.85%, and L:15.23% (w/w) of HPMC amounts in total weight) matrix tablets were prepared by wet granulation technique. The release profiles of the drug and HPMC in a matrix tablet were quantitatively analyzed by HPLC and 1H-Nuclear Magnetic Resonance (NMR) spectroscopy. The hydrodynamic changes of HPMC were determined by the gravimetric behaviors such as swelling and erosion rates, gel layer thickness, front movement data,and distributive Near-Infrared (NIR) chemical imaging of HPMC in a matrix tablet during the dissolution process.

RESULTS

High viscosity HPMC tablets showed slower release of HPMC than the release rate of drug, suggesting that drug release preceded polymer release.Different hydration phenomenon was qualitatively identified and corresponded to the release profiles. The release behaviors of HPMC and drug in the tablet could be distinguished with the significant difference with fitted dissolution kinetics model (Low viscosity HPMC 6cps; Korsmeyer-Peppas model, High viscosity HPMC 4000cps; Hopfenberg model, Paracetamol; Weibull model) according to the weight of ingredients and types of HPMC.

CONCLUSION

The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release- modulating mechanism in the hydrophilic matrix system.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Park C
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton T6G 2E1, Alberta, Canada. College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
Lee JH
College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
Jin G
College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
Ngo HV
College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea.
Park JB
College of Pharmacy, Sahmyook University, Seoul 01795, Republic of Korea.
Tran TTD
Faculty of Pharmacy, Duy Tan University, Danang 550000, Vietnam.
Tran PHL
Deakin University, School of Medicine, Geelong, Australia.
Lee BJ
College of Pharmacy, Ajou University, Suwon 16499, Republic of Korea. Institute of Pharmaceutical Science and Technology, Ajou University, Suwon 16499, Republic of Korea.

MeSH

AcetaminophenDelayed-Action PreparationsDrug LiberationHydrodynamicsHypromellose DerivativesKineticsMethylcellulosePolymersSolubilityTabletsViscosity

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34420504

Citation

Park, Chulhun, et al. "Release Kinetics of Hydroxypropyl Methylcellulose Governing Drug Release and Hydrodynamic Changes of Matrix Tablet." Current Drug Delivery, vol. 19, no. 5, 2022, pp. 520-533.
Park C, Lee JH, Jin G, et al. Release Kinetics of Hydroxypropyl Methylcellulose Governing Drug Release and Hydrodynamic Changes of Matrix Tablet. Curr Drug Deliv. 2022;19(5):520-533.
Park, C., Lee, J. H., Jin, G., Ngo, H. V., Park, J. B., Tran, T. T. D., Tran, P. H. L., & Lee, B. J. (2022). Release Kinetics of Hydroxypropyl Methylcellulose Governing Drug Release and Hydrodynamic Changes of Matrix Tablet. Current Drug Delivery, 19(5), 520-533. https://doi.org/10.2174/1567201818666210820101549
Park C, et al. Release Kinetics of Hydroxypropyl Methylcellulose Governing Drug Release and Hydrodynamic Changes of Matrix Tablet. Curr Drug Deliv. 2022;19(5):520-533. PubMed PMID: 34420504.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Release Kinetics of Hydroxypropyl Methylcellulose Governing Drug Release and Hydrodynamic Changes of Matrix Tablet. AU - Park,Chulhun, AU - Lee,Jong Hoon, AU - Jin,Gang, AU - Ngo,Hai Van, AU - Park,Jun-Bom, AU - Tran,Thao T D, AU - Tran,Phuong H L, AU - Lee,Beom-Jin, PY - 2021/02/04/received PY - 2021/07/13/revised PY - 2021/07/16/accepted PY - 2021/8/24/pubmed PY - 2022/5/24/medline PY - 2021/8/23/entrez KW - Hydroxypropyl methylcellulose KW - distributive imaging of polymer KW - drug release KW - hydrodynamic behaviors KW - polymer release KW - quantitative and qualitative analysis of HPMC SP - 520 EP - 533 JF - Current drug delivery JO - Curr Drug Deliv VL - 19 IS - 5 N2 - BACKGROUND: Hydrophilic Hydroxypropyl Methylcellulose (HPMC) matrix tablets are the standard role model of the oral controlled-release formulation. Nevertheless, the HPMC kinetics for the mechanistic understanding of drug release and hydrodynamic behaviors are rarely investigated. This study aims to investigate the release behaviors of both HPMC and paracetamol (model drug) from the hydrophilic matrix tablet. METHODS: Two different viscosity grades of HPMC were used (Low viscosity: 6 cps, High viscosity: 4,000 cps). Three different ratios of drug/HPMC (H:38.08%, M:22.85%, and L:15.23% (w/w) of HPMC amounts in total weight) matrix tablets were prepared by wet granulation technique. The release profiles of the drug and HPMC in a matrix tablet were quantitatively analyzed by HPLC and 1H-Nuclear Magnetic Resonance (NMR) spectroscopy. The hydrodynamic changes of HPMC were determined by the gravimetric behaviors such as swelling and erosion rates, gel layer thickness, front movement data,and distributive Near-Infrared (NIR) chemical imaging of HPMC in a matrix tablet during the dissolution process. RESULTS: High viscosity HPMC tablets showed slower release of HPMC than the release rate of drug, suggesting that drug release preceded polymer release.Different hydration phenomenon was qualitatively identified and corresponded to the release profiles. The release behaviors of HPMC and drug in the tablet could be distinguished with the significant difference with fitted dissolution kinetics model (Low viscosity HPMC 6cps; Korsmeyer-Peppas model, High viscosity HPMC 4000cps; Hopfenberg model, Paracetamol; Weibull model) according to the weight of ingredients and types of HPMC. CONCLUSION: The determination of HPMC polymer release correlating with drug release, hydrodynamic behavior, and NIR chemical imaging of HPMC can provide new insights into the drug release- modulating mechanism in the hydrophilic matrix system. SN - 1875-5704 UR - https://www.unboundmedicine.com/medline/citation/34420504/Release_Kinetics_of_Hydroxypropyl_Methylcellulose_Governing_Drug_Release_and_Hydrodynamic_Changes_of_Matrix_Tablet_ DB - PRIME DP - Unbound Medicine ER -