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delta-Aminolevulinic acid dehydratase isozymes and lead toxicity.
Ann N Y Acad Sci 1987; 514:23-9AN

Abstract

ALAD is a zinc metalloenzyme whose inhibition by lead is the first and most sensitive indicator of lead exposure and whose decreased activity has been implicated in the pathogenesis of lead poisoning. This heme biosynthetic enzyme is encoded by a gene located at chromosome 9q34, which has two codominant alleles, ALAD1 and ALAD2. The occurrence of two frequent alleles for ALAD stimulated an investigation into the possible pharmacogenetic role of the enzyme polymorphism in lead poisoning. In a New York City population at high risk for lead exposure, individuals heterozygous or homozygous for the less common allele, ALAD2, had blood lead levels greater than or equal to 30 micrograms/dl more frequently than expected. These findings suggest a potential genetic susceptibility to lead poisoning in individuals with the ALAD 1-2 and 2-2 phenotypes.

Authors+Show Affiliations

Department of Pediatrics, Mount Sinai School of Medicine, New York, New York 10029.

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3442386

Citation

Astrin, K H., et al. "Delta-Aminolevulinic Acid Dehydratase Isozymes and Lead Toxicity." Annals of the New York Academy of Sciences, vol. 514, 1987, pp. 23-9.
Astrin KH, Bishop DF, Wetmur JG, et al. Delta-Aminolevulinic acid dehydratase isozymes and lead toxicity. Ann N Y Acad Sci. 1987;514:23-9.
Astrin, K. H., Bishop, D. F., Wetmur, J. G., Kaul, B., Davidow, B., & Desnick, R. J. (1987). Delta-Aminolevulinic acid dehydratase isozymes and lead toxicity. Annals of the New York Academy of Sciences, 514, pp. 23-9.
Astrin KH, et al. Delta-Aminolevulinic Acid Dehydratase Isozymes and Lead Toxicity. Ann N Y Acad Sci. 1987;514:23-9. PubMed PMID: 3442386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - delta-Aminolevulinic acid dehydratase isozymes and lead toxicity. AU - Astrin,K H, AU - Bishop,D F, AU - Wetmur,J G, AU - Kaul,B, AU - Davidow,B, AU - Desnick,R J, PY - 1987/1/1/pubmed PY - 1987/1/1/medline PY - 1987/1/1/entrez SP - 23 EP - 9 JF - Annals of the New York Academy of Sciences JO - Ann. N. Y. Acad. Sci. VL - 514 N2 - ALAD is a zinc metalloenzyme whose inhibition by lead is the first and most sensitive indicator of lead exposure and whose decreased activity has been implicated in the pathogenesis of lead poisoning. This heme biosynthetic enzyme is encoded by a gene located at chromosome 9q34, which has two codominant alleles, ALAD1 and ALAD2. The occurrence of two frequent alleles for ALAD stimulated an investigation into the possible pharmacogenetic role of the enzyme polymorphism in lead poisoning. In a New York City population at high risk for lead exposure, individuals heterozygous or homozygous for the less common allele, ALAD2, had blood lead levels greater than or equal to 30 micrograms/dl more frequently than expected. These findings suggest a potential genetic susceptibility to lead poisoning in individuals with the ALAD 1-2 and 2-2 phenotypes. SN - 0077-8923 UR - https://www.unboundmedicine.com/medline/citation/3442386/delta_Aminolevulinic_acid_dehydratase_isozymes_and_lead_toxicity_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0077-8923&date=1987&volume=514&spage=23 DB - PRIME DP - Unbound Medicine ER -