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Frequency of juvenile idiopathic arthritis and associated uveitis in pediatric rheumatology clinics in Turkey: A retrospective study, JUPITER.
Pediatr Rheumatol Online J. 2021 Aug 23; 19(1):134.PR

Abstract

BACKGROUND

Juvenile idiopathic arthritis (JIA), is the most common pediatric rheumatologic disorder with unknown etiology. Currently, no population-based data are available regarding the distribution of categories and frequency of uveitis in patients with JIA in Turkey. The purpose of this study was to evaluate the frequency of JIA-associated uveitis (JIAU) and distribution of JIA categories in a Turkish JIA cohort.

METHODS

This was a retrospective study of 500 randomized patients in four pediatric rheumatology clinics in Turkey.

RESULTS

Oligoarticular JIA (oJIA) was the most common JIA disease category in this study cohort (38.8%). The frequencies of the other categories were as follows: enthesitis-related arthritis (ERA), 23.2%; rheumatoid factor (RF)-negative polyarthritis, 15.6%; systemic arthritis, 12.2%; juvenile psoriatic arthritis, 5.2%; undifferentiated arthritis, 2.8%; and RF-positive polyarthritis, 2.2%. JIA-associated uveitis was observed in 6.8% of patients at a mean (Standard Deviation, SD) age of 9.1 (3.8) years over a mean JIA disease duration of 4 (1.9) years. Uveitis developed after joint disease, with a mean (SD) duration of 1.8 (1.9) years. Patients with oJIA had the highest rate of uveitis (12.9%) followed by patients with ERA (5.2%) and polyarticular RF-negative disease (3.8%). Compared with persistent oJIA, the extended oJIA category had a > 3-fold higher risk of uveitis (11.3% vs 27.7%; odds ratio, 3.38 [95% Confidence Interval, 1.09-10.4]). The most frequently administered drug after development of uveitis was tumor necrosis factor-alpha inhibitors (38.2%). Five patients (14.7%) had uveitis-related complications that required surgical intervention.

CONCLUSIONS

Turkish pediatric patients with JIA experience a lower frequency of oJIA and higher frequency of ERA than their white European counterparts; the occurrence of uveitis is also somewhat lower than expected. Geographic and ethnic factors may affect these differences and need further investigation.

Links

Authors+Show Affiliations

Istanbul University-Cerrahpasa, School of Medicine, Koca Mustafapaşa Cd. No:53, Fatih, 34098, Istanbul, Turkey.

Dokuz Eylul University, School of Medicine, Izmir, Turkey.

Hacettepe University, School of Medicine, Ankara, Turkey.

Umraniye Training and Research Hospital, Istanbul, Turkey.

Hacettepe University, School of Medicine, Ankara, Turkey.

Dokuz Eylul University, School of Medicine, Izmir, Turkey.

Istanbul University-Cerrahpasa, School of Medicine, Koca Mustafapaşa Cd. No:53, Fatih, 34098, Istanbul, Turkey.

Hacettepe University, School of Medicine, Ankara, Turkey.

Istanbul University-Cerrahpasa, School of Medicine, Koca Mustafapaşa Cd. No:53, Fatih, 34098, Istanbul, Turkey.

Hacettepe University, School of Medicine, Ankara, Turkey.

Umraniye Training and Research Hospital, Istanbul, Turkey.

Dokuz Eylul University, School of Medicine, Izmir, Turkey.

Hacettepe University, School of Medicine, Ankara, Turkey.

Istanbul University-Cerrahpasa, School of Medicine, Koca Mustafapaşa Cd. No:53, Fatih, 34098, Istanbul, Turkey. ozgurkasapcopur@hotmail.com.

MeSH

AdolescentArthritis, JuvenileChildCohort StudiesFemaleHLA-B27 AntigenHumansMalePatient AcuityPatient Care ManagementPrevalenceRandom AllocationRetrospective StudiesRisk AssessmentSeverity of Illness IndexTumor Necrosis Factor InhibitorsTurkeyUveitis

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34425847

Citation

Sahin, Sezgin, et al. "Frequency of Juvenile Idiopathic Arthritis and Associated Uveitis in Pediatric Rheumatology Clinics in Turkey: a Retrospective Study, JUPITER." Pediatric Rheumatology Online Journal, vol. 19, no. 1, 2021, p. 134.

Sahin S, Acari C, Sonmez HE, et al. Frequency of juvenile idiopathic arthritis and associated uveitis in pediatric rheumatology clinics in Turkey: A retrospective study, JUPITER. Pediatr Rheumatol Online J. 2021;19(1):134.

Sahin, S., Acari, C., Sonmez, H. E., Kilic, F. Z., Sag, E., Dundar, H. A., Adrovic, A., Demir, S., Barut, K., Bilginer, Y., Sozeri, B., Unsal, E., Ozen, S., & Kasapcopur, O. (2021). Frequency of juvenile idiopathic arthritis and associated uveitis in pediatric rheumatology clinics in Turkey: A retrospective study, JUPITER. Pediatric Rheumatology Online Journal, 19(1), 134. https://doi.org/10.1186/s12969-021-00613-2

Sahin S, et al. Frequency of Juvenile Idiopathic Arthritis and Associated Uveitis in Pediatric Rheumatology Clinics in Turkey: a Retrospective Study, JUPITER. Pediatr Rheumatol Online J. 2021 Aug 23;19(1):134. PubMed PMID: 34425847.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Frequency of juvenile idiopathic arthritis and associated uveitis in pediatric rheumatology clinics in Turkey: A retrospective study, JUPITER. AU - Sahin,Sezgin, AU - Acari,Ceyhun, AU - Sonmez,Hafize Emine, AU - Kilic,Fatma Zehra, AU - Sag,Erdal, AU - Dundar,Hatice Adiguzel, AU - Adrovic,Amra, AU - Demir,Selcan, AU - Barut,Kenan, AU - Bilginer,Yelda, AU - Sozeri,Betul, AU - Unsal,Erbil, AU - Ozen,Seza, AU - Kasapcopur,Ozgur, Y1 - 2021/08/23/ PY - 2021/01/08/received PY - 2021/06/13/accepted PY - 2021/8/24/entrez PY - 2021/8/25/pubmed PY - 2022/1/11/medline KW - ANA KW - Frequency KW - HLA-B27 KW - Juvenile idiopathic arthritis KW - Turkey KW - Uveitis SP - 134 EP - 134 JF - Pediatric rheumatology online journal JO - Pediatr Rheumatol Online J VL - 19 IS - 1 N2 - BACKGROUND: Juvenile idiopathic arthritis (JIA), is the most common pediatric rheumatologic disorder with unknown etiology. Currently, no population-based data are available regarding the distribution of categories and frequency of uveitis in patients with JIA in Turkey. The purpose of this study was to evaluate the frequency of JIA-associated uveitis (JIAU) and distribution of JIA categories in a Turkish JIA cohort. METHODS: This was a retrospective study of 500 randomized patients in four pediatric rheumatology clinics in Turkey. RESULTS: Oligoarticular JIA (oJIA) was the most common JIA disease category in this study cohort (38.8%). The frequencies of the other categories were as follows: enthesitis-related arthritis (ERA), 23.2%; rheumatoid factor (RF)-negative polyarthritis, 15.6%; systemic arthritis, 12.2%; juvenile psoriatic arthritis, 5.2%; undifferentiated arthritis, 2.8%; and RF-positive polyarthritis, 2.2%. JIA-associated uveitis was observed in 6.8% of patients at a mean (Standard Deviation, SD) age of 9.1 (3.8) years over a mean JIA disease duration of 4 (1.9) years. Uveitis developed after joint disease, with a mean (SD) duration of 1.8 (1.9) years. Patients with oJIA had the highest rate of uveitis (12.9%) followed by patients with ERA (5.2%) and polyarticular RF-negative disease (3.8%). Compared with persistent oJIA, the extended oJIA category had a > 3-fold higher risk of uveitis (11.3% vs 27.7%; odds ratio, 3.38 [95% Confidence Interval, 1.09-10.4]). The most frequently administered drug after development of uveitis was tumor necrosis factor-alpha inhibitors (38.2%). Five patients (14.7%) had uveitis-related complications that required surgical intervention. CONCLUSIONS: Turkish pediatric patients with JIA experience a lower frequency of oJIA and higher frequency of ERA than their white European counterparts; the occurrence of uveitis is also somewhat lower than expected. Geographic and ethnic factors may affect these differences and need further investigation. SN - 1546-0096 UR - https://www.unboundmedicine.com/medline/citation/34425847/Frequency_of_juvenile_idiopathic_arthritis_and_associated_uveitis_in_pediatric_rheumatology_clinics_in_Turkey:_A_retrospective_study_JUPITER_ DB - PRIME DP - Unbound Medicine ER -