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Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review.
Molecules. 2021 Aug 19; 26(16)M

Abstract

Black garlic (BG) is a form of aged garlic obtained from raw garlic (Allium sativum) via Millard reaction under high temperature (60-90 °C) and humidity (70-90%) for a period of time. Several studies reported higher contents of water-soluble antioxidants compounds (S-allyl cysteine, S-allyl-mercapto cysteine), 5-hydroxymethylfurfural, organosulfur compounds, polyphenol, volatile compounds, and products of other Millard reactions compared to fresh garlic after the thermal processing. Recent studies have demonstrated that BG and its bioactive compounds possess a wide range of biological activities and pharmacological properties that preserve and show better efficacy in preventing different types of diseases. Most of these benefits can be attributed to its anti-oxidation, anti-inflammation, anti-obesity, hepatoprotection, hypolipidemia, anti-cancer, anti-allergy, immunomodulation, nephroprotection, cardiovascular protection, and neuroprotection. Substantial studies have been conducted on BG and its components against different common human diseases in the last few decades. Still, a lot of research is ongoing to find out the therapeutic effects of BG. Thus, in this review, we summarized the pre-clinical and clinical studies of BG and its bioactive compounds on human health along with diverse bioactivity, a related mode of action, and also future challenges.

Authors+Show Affiliations

Department of Nutrition, Chung Shan Medical University, 110, Section 1, Jianguo North Road, Taichung 40201, Taiwan.Department of Nutrition, Chung Shan Medical University, 110, Section 1, Jianguo North Road, Taichung 40201, Taiwan.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34443625

Citation

Ahmed, Tanvir, and Chin-Kun Wang. "Black Garlic and Its Bioactive Compounds On Human Health Diseases: a Review." Molecules (Basel, Switzerland), vol. 26, no. 16, 2021.
Ahmed T, Wang CK. Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review. Molecules. 2021;26(16).
Ahmed, T., & Wang, C. K. (2021). Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review. Molecules (Basel, Switzerland), 26(16). https://doi.org/10.3390/molecules26165028
Ahmed T, Wang CK. Black Garlic and Its Bioactive Compounds On Human Health Diseases: a Review. Molecules. 2021 Aug 19;26(16) PubMed PMID: 34443625.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Black Garlic and Its Bioactive Compounds on Human Health Diseases: A Review. AU - Ahmed,Tanvir, AU - Wang,Chin-Kun, Y1 - 2021/08/19/ PY - 2021/07/01/received PY - 2021/08/09/revised PY - 2021/08/12/accepted PY - 2021/8/27/entrez PY - 2021/8/28/pubmed PY - 2021/9/8/medline KW - bioavailability KW - black garlic KW - health benefits KW - health diseases JF - Molecules (Basel, Switzerland) JO - Molecules VL - 26 IS - 16 N2 - Black garlic (BG) is a form of aged garlic obtained from raw garlic (Allium sativum) via Millard reaction under high temperature (60-90 °C) and humidity (70-90%) for a period of time. Several studies reported higher contents of water-soluble antioxidants compounds (S-allyl cysteine, S-allyl-mercapto cysteine), 5-hydroxymethylfurfural, organosulfur compounds, polyphenol, volatile compounds, and products of other Millard reactions compared to fresh garlic after the thermal processing. Recent studies have demonstrated that BG and its bioactive compounds possess a wide range of biological activities and pharmacological properties that preserve and show better efficacy in preventing different types of diseases. Most of these benefits can be attributed to its anti-oxidation, anti-inflammation, anti-obesity, hepatoprotection, hypolipidemia, anti-cancer, anti-allergy, immunomodulation, nephroprotection, cardiovascular protection, and neuroprotection. Substantial studies have been conducted on BG and its components against different common human diseases in the last few decades. Still, a lot of research is ongoing to find out the therapeutic effects of BG. Thus, in this review, we summarized the pre-clinical and clinical studies of BG and its bioactive compounds on human health along with diverse bioactivity, a related mode of action, and also future challenges. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/34443625/Black_Garlic_and_Its_Bioactive_Compounds_on_Human_Health_Diseases:_A_Review_ L2 - https://www.mdpi.com/resolver?pii=molecules26165028 DB - PRIME DP - Unbound Medicine ER -
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