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Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials.
Nutrients. 2021 Jul 24; 13(8)N

Abstract

The aim of the report was to evaluate the impact of soy protein containing isoflavones and soy isoflavones extract on lipid profile in postmenopausal women, as compared with placebo or protein of milk, casein or isolated soy protein with or without trace isoflavone content. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Quantitative data synthesis was performed by applying a random-effects model. Subgroup analysis and meta-regression were performed to assess the modifiers of treatment response. In total, in the analysis studies, 2305 postmenopausal women took part. Changes in the lipid profile showed statistically significant decreases of total cholesterol by -0.12 (95% CI: -0.21, -0.03) mmol/L, -4.64 (95% CI: -8.12, -1.16) mg/dL, p = 0.01 and increased HDL-cholesterol by 0.03 (95% CI: 0.00, 0.06) mmol/L, 1.15 (95% CI: 0.00, 1.93) mg/dL, p = 0.05, as well as in LDL-cholesterol -0.05 (95% CI: -0.11, 0.01) mmol/L, -1.93 (95% CI: -4.25, 0.39) mg/dL, p = 0.08 and triacylglycerols -0.07 (95% CI: -0.14, 0.00) mmol/L, -6.123 (95% CI: -12.25, 0.00) mg/dL, p = 0.06. Our results suggests that soy and its isoflavones can be effective in correction changes in lipid metabolism in postmenopausal women and may favorably influence in preventing cardiovascular events.

Authors+Show Affiliations

Department of Medical Informatics and Statistics with E-Learning Lab, Medical University of Lublin, 20-090 Lublin, Poland.Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.Specialistic Medical Center Czechow, 20-848 Lublin, Poland.Chair of Internal Medicine and Department of Internal Medicine in Nursing, Medical University of Lublin, 20-093 Lublin, Poland.Department of Medical Informatics and Statistics with E-Learning Lab, Medical University of Lublin, 20-090 Lublin, Poland.Department of Paediatric Pulmonology and Rheumatology, Medical University of Lublin, 20-093 Lublin, Poland.Department of Virology with SARS Laboratory, Medical University of Lublin, 20-093 Lublin, Poland.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

34444691

Citation

Barańska, Agnieszka, et al. "Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract On Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials." Nutrients, vol. 13, no. 8, 2021.
Barańska A, Błaszczuk A, Kanadys W, et al. Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021;13(8).
Barańska, A., Błaszczuk, A., Kanadys, W., Baczewska, B., Jędrych, M., Wawryk-Gawda, E., & Polz-Dacewicz, M. (2021). Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients, 13(8). https://doi.org/10.3390/nu13082531
Barańska A, et al. Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract On Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials. Nutrients. 2021 Jul 24;13(8) PubMed PMID: 34444691.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials. AU - Barańska,Agnieszka, AU - Błaszczuk,Agata, AU - Kanadys,Wiesław, AU - Baczewska,Bożena, AU - Jędrych,Marian, AU - Wawryk-Gawda,Ewelina, AU - Polz-Dacewicz,Małgorzata, Y1 - 2021/07/24/ PY - 2021/06/04/received PY - 2021/07/14/revised PY - 2021/07/22/accepted PY - 2021/8/27/entrez PY - 2021/8/28/pubmed PY - 2021/9/16/medline KW - HDL-C KW - LDL-C KW - TAG KW - TC KW - cardiovascular diseases KW - lipid profile KW - postmenopausal women KW - soy isoflavones extracts KW - soy protein containing isoflavones JF - Nutrients JO - Nutrients VL - 13 IS - 8 N2 - The aim of the report was to evaluate the impact of soy protein containing isoflavones and soy isoflavones extract on lipid profile in postmenopausal women, as compared with placebo or protein of milk, casein or isolated soy protein with or without trace isoflavone content. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Quantitative data synthesis was performed by applying a random-effects model. Subgroup analysis and meta-regression were performed to assess the modifiers of treatment response. In total, in the analysis studies, 2305 postmenopausal women took part. Changes in the lipid profile showed statistically significant decreases of total cholesterol by -0.12 (95% CI: -0.21, -0.03) mmol/L, -4.64 (95% CI: -8.12, -1.16) mg/dL, p = 0.01 and increased HDL-cholesterol by 0.03 (95% CI: 0.00, 0.06) mmol/L, 1.15 (95% CI: 0.00, 1.93) mg/dL, p = 0.05, as well as in LDL-cholesterol -0.05 (95% CI: -0.11, 0.01) mmol/L, -1.93 (95% CI: -4.25, 0.39) mg/dL, p = 0.08 and triacylglycerols -0.07 (95% CI: -0.14, 0.00) mmol/L, -6.123 (95% CI: -12.25, 0.00) mg/dL, p = 0.06. Our results suggests that soy and its isoflavones can be effective in correction changes in lipid metabolism in postmenopausal women and may favorably influence in preventing cardiovascular events. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/34444691/Effects_of_Soy_Protein_Containing_of_Isoflavones_and_Isoflavones_Extract_on_Plasma_Lipid_Profile_in_Postmenopausal_Women_as_a_Potential_Prevention_Factor_in_Cardiovascular_Diseases:_Systematic_Review_and_Meta_Analysis_of_Randomized_Controlled_Trials_ L2 - https://www.mdpi.com/resolver?pii=nu13082531 DB - PRIME DP - Unbound Medicine ER -