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[Anti-alpha-gliadin antibodies. Sensitivity, specificity and correlation with blood xylose test in the 3 diagnostic stages of celiac disease in children].
Pediatr Med Chir. 1987 Nov-Dec; 9(6):653-60.PM

Abstract

The specificity and sensibility of IgA and IgG alfagliadin antibody test (AaGA) for screening, diagnosis and follow-up of childhood coeliac disease has been evaluated. We have compared AaGA test to D-xylose blood test and at last we have examined the false positive and negative results given by the test. Two groups of subjects were considered: 1) 90 children with untreated coeliac disease (21 newly diagnosed (I stage), 50 in gluten withdrawal (II stage), 19 in challenge (III stage); 2) 255 disease controls including: 157 healthy controls; 31 children with gastroenterological disorders other than coeliac disease; 31 children with food allergy and atopic dermatitis; 36 children with "constitutional" short stature (without GH deficiency and with normal intestinal mucosa). The sensibility of AaGA test in the first stage of coeliac disease has been of 95.2% for the IgG class antibody and 90.4% for the IgA class; on the other hand the showed a specificity of 83.6% for IgG class antibody and 96.9% for IgA class. In only two newly diagnosed coeliac children we have found false negative results: in the first case the patient was IgA-deficient, in the second the age was above 3 years. AaGA IgA resulted positive only in the 12.9% of the group of gastroenterological and atopic controls; particularly most cases were affected by multiple food allergies and two patients by chronic autoimmune disease of small intestine.(ABSTRACT TRUNCATED AT 250 WORDS)

Authors+Show Affiliations

Clinica Pediatrica, Istituto per l'Infanzia di Trieste, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

3444740

Citation

Ventura, A, et al. "[Anti-alpha-gliadin Antibodies. Sensitivity, Specificity and Correlation With Blood Xylose Test in the 3 Diagnostic Stages of Celiac Disease in Children]." La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, vol. 9, no. 6, 1987, pp. 653-60.
Ventura A, Florean P, Trevisan M, et al. [Anti-alpha-gliadin antibodies. Sensitivity, specificity and correlation with blood xylose test in the 3 diagnostic stages of celiac disease in children]. Pediatr Med Chir. 1987;9(6):653-60.
Ventura, A., Florean, P., Trevisan, M., Not, T., Perticarari, S., Quadrifoglio, F., Torre, G., & Cauci, S. (1987). [Anti-alpha-gliadin antibodies. Sensitivity, specificity and correlation with blood xylose test in the 3 diagnostic stages of celiac disease in children]. La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, 9(6), 653-60.
Ventura A, et al. [Anti-alpha-gliadin Antibodies. Sensitivity, Specificity and Correlation With Blood Xylose Test in the 3 Diagnostic Stages of Celiac Disease in Children]. Pediatr Med Chir. 1987 Nov-Dec;9(6):653-60. PubMed PMID: 3444740.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anti-alpha-gliadin antibodies. Sensitivity, specificity and correlation with blood xylose test in the 3 diagnostic stages of celiac disease in children]. AU - Ventura,A, AU - Florean,P, AU - Trevisan,M, AU - Not,T, AU - Perticarari,S, AU - Quadrifoglio,F, AU - Torre,G, AU - Cauci,S, PY - 1987/11/1/pubmed PY - 1987/11/1/medline PY - 1987/11/1/entrez SP - 653 EP - 60 JF - La Pediatria medica e chirurgica : Medical and surgical pediatrics JO - Pediatr Med Chir VL - 9 IS - 6 N2 - The specificity and sensibility of IgA and IgG alfagliadin antibody test (AaGA) for screening, diagnosis and follow-up of childhood coeliac disease has been evaluated. We have compared AaGA test to D-xylose blood test and at last we have examined the false positive and negative results given by the test. Two groups of subjects were considered: 1) 90 children with untreated coeliac disease (21 newly diagnosed (I stage), 50 in gluten withdrawal (II stage), 19 in challenge (III stage); 2) 255 disease controls including: 157 healthy controls; 31 children with gastroenterological disorders other than coeliac disease; 31 children with food allergy and atopic dermatitis; 36 children with "constitutional" short stature (without GH deficiency and with normal intestinal mucosa). The sensibility of AaGA test in the first stage of coeliac disease has been of 95.2% for the IgG class antibody and 90.4% for the IgA class; on the other hand the showed a specificity of 83.6% for IgG class antibody and 96.9% for IgA class. In only two newly diagnosed coeliac children we have found false negative results: in the first case the patient was IgA-deficient, in the second the age was above 3 years. AaGA IgA resulted positive only in the 12.9% of the group of gastroenterological and atopic controls; particularly most cases were affected by multiple food allergies and two patients by chronic autoimmune disease of small intestine.(ABSTRACT TRUNCATED AT 250 WORDS) SN - 0391-5387 UR - https://www.unboundmedicine.com/medline/citation/3444740/[Anti_alpha_gliadin_antibodies__Sensitivity_specificity_and_correlation_with_blood_xylose_test_in_the_3_diagnostic_stages_of_celiac_disease_in_children]_ DB - PRIME DP - Unbound Medicine ER -