TY - JOUR T1 - The Neuroprotective Effects of Moderate and Regular Caffeine Consumption in Alzheimer's Disease. AU - Zhou,Xiangyu, AU - Zhang,Lin, Y1 - 2021/08/17/ PY - 2021/1/21/received PY - 2021/6/27/revised PY - 2021/7/19/accepted PY - 2021/8/27/entrez PY - 2021/8/28/pubmed PY - 2022/1/20/medline SP - 5568011 EP - 5568011 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2021 N2 - The increasing numbers of elderly Alzheimer's disease (AD) patients because of a steady increase in the average lifespan and aging society attract great scientific concerns, while there were fewer effective treatments on AD progression due to unclear exact causes and pathogenesis of AD. Moderate (200-500 mg/d) and regular caffeine consumption from coffee and tea are considered to alleviate the risk of AD and have therapeutic potential. This paper reviewed epidemiological studies about the relationship of caffeine intake from coffee or/and tea with the risk of AD and summarized the caffeine-related AD therapies based on experimental models. And further well-designed and well-conducted studies are suggested to investigate the optimal dosages, frequencies, and durations of caffeine consumption to slow down AD progression and treat AD. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/34447487/The_Neuroprotective_Effects_of_Moderate_and_Regular_Caffeine_Consumption_in_Alzheimer's_Disease_ DB - PRIME DP - Unbound Medicine ER -