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Virucidal Efficacy of Blue LED and Far-UVC Light Disinfection against Feline Infectious Peritonitis Virus as a Model for SARS-CoV-2.
Viruses. 2021 07 23; 13(8)V

Abstract

Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs through respiratory droplets passed directly from person to person or indirectly through fomites, such as common use surfaces or objects. The aim of this study was to determine the virucidal efficacy of blue LED (405 nm) and far-UVC (222 nm) light in comparison to standard UVC (254 nm) irradiation for the inactivation of feline infectious peritonitis virus (FIPV) on different matrices as a model for SARS-CoV-2. Wet or dried FIPV on stainless steel, plastic, or paper discs, in the presence or absence of artificial saliva, were exposed to various wavelengths of light for different time periods (1-90 min). Dual activity of blue LED and far-UVC lights were virucidal for most wet and dried FIPV within 4 to 16 min on all matrices. Individual action of blue LED and far-UVC lights were virucidal for wet FIPV but required longer irradiation times (8-90 min) to reach a 4-log reduction. In comparison, LED (265 nm) and germicidal UVC (254 nm) were virucidal on almost all matrices for both wet and dried FIPV within 1 min exposure. UVC was more effective for the disinfection of surfaces as compared to blue LED and far-UVC individually or together. However, dual action of blue LED and far-UVC was virucidal. This combination of lights could be used as a safer alternative to traditional UVC.

Authors+Show Affiliations

AgResearch Ltd., Hopkirk Research Institute, Massey University, Corner University Ave and Library Road, Palmerston North 4442, New Zealand.School of Veterinary Science, Massey University Manawatu (Turitea), Tennent Drive, Palmerston North 4474, New Zealand.School of Veterinary Science, Massey University Manawatu (Turitea), Tennent Drive, Palmerston North 4474, New Zealand.AgResearch Ltd., Hopkirk Research Institute, Massey University, Corner University Ave and Library Road, Palmerston North 4442, New Zealand. New Zealand Food Safety Science and Research Centre, Massey University Manawatu (Turitea), Tennent Drive, Palmerston North 4474, New Zealand.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34452302

Citation

Gardner, Amanda, et al. "Virucidal Efficacy of Blue LED and Far-UVC Light Disinfection Against Feline Infectious Peritonitis Virus as a Model for SARS-CoV-2." Viruses, vol. 13, no. 8, 2021.
Gardner A, Ghosh S, Dunowska M, et al. Virucidal Efficacy of Blue LED and Far-UVC Light Disinfection against Feline Infectious Peritonitis Virus as a Model for SARS-CoV-2. Viruses. 2021;13(8).
Gardner, A., Ghosh, S., Dunowska, M., & Brightwell, G. (2021). Virucidal Efficacy of Blue LED and Far-UVC Light Disinfection against Feline Infectious Peritonitis Virus as a Model for SARS-CoV-2. Viruses, 13(8). https://doi.org/10.3390/v13081436
Gardner A, et al. Virucidal Efficacy of Blue LED and Far-UVC Light Disinfection Against Feline Infectious Peritonitis Virus as a Model for SARS-CoV-2. Viruses. 2021 07 23;13(8) PubMed PMID: 34452302.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Virucidal Efficacy of Blue LED and Far-UVC Light Disinfection against Feline Infectious Peritonitis Virus as a Model for SARS-CoV-2. AU - Gardner,Amanda, AU - Ghosh,Sayani, AU - Dunowska,Magdalena, AU - Brightwell,Gale, Y1 - 2021/07/23/ PY - 2021/06/23/received PY - 2021/07/16/revised PY - 2021/07/19/accepted PY - 2021/8/28/entrez PY - 2021/8/29/pubmed PY - 2021/9/11/medline KW - 405 nm blue light KW - coronavirus KW - far-UVC KW - feline infectious peritonitis virus KW - light disinfection KW - pandemic KW - ultraviolet light KW - viral inactivation JF - Viruses JO - Viruses VL - 13 IS - 8 N2 - Transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs through respiratory droplets passed directly from person to person or indirectly through fomites, such as common use surfaces or objects. The aim of this study was to determine the virucidal efficacy of blue LED (405 nm) and far-UVC (222 nm) light in comparison to standard UVC (254 nm) irradiation for the inactivation of feline infectious peritonitis virus (FIPV) on different matrices as a model for SARS-CoV-2. Wet or dried FIPV on stainless steel, plastic, or paper discs, in the presence or absence of artificial saliva, were exposed to various wavelengths of light for different time periods (1-90 min). Dual activity of blue LED and far-UVC lights were virucidal for most wet and dried FIPV within 4 to 16 min on all matrices. Individual action of blue LED and far-UVC lights were virucidal for wet FIPV but required longer irradiation times (8-90 min) to reach a 4-log reduction. In comparison, LED (265 nm) and germicidal UVC (254 nm) were virucidal on almost all matrices for both wet and dried FIPV within 1 min exposure. UVC was more effective for the disinfection of surfaces as compared to blue LED and far-UVC individually or together. However, dual action of blue LED and far-UVC was virucidal. This combination of lights could be used as a safer alternative to traditional UVC. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/34452302/Virucidal_Efficacy_of_Blue_LED_and_Far_UVC_Light_Disinfection_against_Feline_Infectious_Peritonitis_Virus_as_a_Model_for_SARS_CoV_2_ L2 - https://www.mdpi.com/resolver?pii=v13081436 DB - PRIME DP - Unbound Medicine ER -