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The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin-6 and tumour necrosis factor-α among post-menopausal women? A systematic review and meta-analysis of randomized controlled trials.
Clin Exp Pharmacol Physiol. 2022 01; 49(1):10-24.CE

Abstract

The post-menopausal stage in women's life is associated with the enhancement of inflammation that may be reduced using soy isoflavones or soy protein. The present study aimed to summarize the effect of soy isoflavones plus soy protein on circulating interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in post-menopausal women. The English-language articles were identified from the databases such as Cochrane Library, clinicaltrials.gov, Web of Science, PubMed, and Scopus until December 2020. The mean change from baseline and its standard deviation (SD) for intervention and comparison groups were used to calculate the effect size. The statistical heterogeneity of the intervention effects was computing by Cochran's Q test and I2 statistic. Nine and seven studies were selected for systematic review and meta-analysis, respectively. The results of our meta-analysis indicated a non-significant effect on the serum concentrations of IL-6 and TNF-α (weighted mean differences [WMD] = 0.07 pg/mL; 95% confidence interval [CI] = -0.03, 0.17 pg/mL; P = 0.190; WMD =0.05 pg/mL; 95% CI = -0.01, 0.12 pg/mL; P = 0.092; respectively). In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose ≤87 mg/days, cross-over design, weak quality, and studies on participants who had health risk factors or diseases. The serum concentration of TNF-α increased in studies with cross-over design, intervention duration ≤56 days, and body mass index (BMI) >27, and in studies that were conducted on at-risk or sick participants. In conclusion, our meta-analysis did not confirm any significant effect on serum concentration of IL-6 and TNF-α among post-menopausal women.

Authors+Show Affiliations

Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Department of Epidemiology and Biostatistics, School of Public Health, Neyshabur University of Medical Sciences, Neyshabur, Iran.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran.Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. Ageing Clinical and Experimental Research Team, Institute of Applied Health Sciences, School of Medicine, Medical Sciences and Nutrition University of Aberdeen, Aberdeen, UK.Noncommunicable Diseases Research Center, Neyshabur University of Medical Sciences, Neyshabur, Iran. Healthy Ageing Research Centre, Neyshabur University of Medical Sciences, Neyshabur, Iran.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

34455600

Citation

Gholami, Ali, et al. "The Efficacy of Soy Isoflavones Combined With Soy Protein On Serum Concentration of Interleukin-6 and Tumour Necrosis Factor-α Among Post-menopausal Women? a Systematic Review and Meta-analysis of Randomized Controlled Trials." Clinical and Experimental Pharmacology & Physiology, vol. 49, no. 1, 2022, pp. 10-24.
Gholami A, Mollanoroozy E, Reza Baradaran H, et al. The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin-6 and tumour necrosis factor-α among post-menopausal women? A systematic review and meta-analysis of randomized controlled trials. Clin Exp Pharmacol Physiol. 2022;49(1):10-24.
Gholami, A., Mollanoroozy, E., Reza Baradaran, H., & Hariri, M. (2022). The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin-6 and tumour necrosis factor-α among post-menopausal women? A systematic review and meta-analysis of randomized controlled trials. Clinical and Experimental Pharmacology & Physiology, 49(1), 10-24. https://doi.org/10.1111/1440-1681.13586
Gholami A, et al. The Efficacy of Soy Isoflavones Combined With Soy Protein On Serum Concentration of Interleukin-6 and Tumour Necrosis Factor-α Among Post-menopausal Women? a Systematic Review and Meta-analysis of Randomized Controlled Trials. Clin Exp Pharmacol Physiol. 2022;49(1):10-24. PubMed PMID: 34455600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin-6 and tumour necrosis factor-α among post-menopausal women? A systematic review and meta-analysis of randomized controlled trials. AU - Gholami,Ali, AU - Mollanoroozy,Ensiyeh, AU - Reza Baradaran,Hamid, AU - Hariri,Mitra, Y1 - 2021/10/04/ PY - 2021/08/24/revised PY - 2021/06/20/received PY - 2021/08/26/accepted PY - 2021/8/30/pubmed PY - 2022/3/30/medline PY - 2021/8/29/entrez KW - interleukin-6 KW - meta-analysis KW - post-menopause KW - soy foods KW - systematic review KW - tumour necrosis factor-alpha SP - 10 EP - 24 JF - Clinical and experimental pharmacology & physiology JO - Clin Exp Pharmacol Physiol VL - 49 IS - 1 N2 - The post-menopausal stage in women's life is associated with the enhancement of inflammation that may be reduced using soy isoflavones or soy protein. The present study aimed to summarize the effect of soy isoflavones plus soy protein on circulating interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) in post-menopausal women. The English-language articles were identified from the databases such as Cochrane Library, clinicaltrials.gov, Web of Science, PubMed, and Scopus until December 2020. The mean change from baseline and its standard deviation (SD) for intervention and comparison groups were used to calculate the effect size. The statistical heterogeneity of the intervention effects was computing by Cochran's Q test and I2 statistic. Nine and seven studies were selected for systematic review and meta-analysis, respectively. The results of our meta-analysis indicated a non-significant effect on the serum concentrations of IL-6 and TNF-α (weighted mean differences [WMD] = 0.07 pg/mL; 95% confidence interval [CI] = -0.03, 0.17 pg/mL; P = 0.190; WMD =0.05 pg/mL; 95% CI = -0.01, 0.12 pg/mL; P = 0.092; respectively). In subgroup analysis, soy isoflavones plus soy protein could increase the serum concentration of IL-6 in studies with soy isoflavones dose ≤87 mg/days, cross-over design, weak quality, and studies on participants who had health risk factors or diseases. The serum concentration of TNF-α increased in studies with cross-over design, intervention duration ≤56 days, and body mass index (BMI) >27, and in studies that were conducted on at-risk or sick participants. In conclusion, our meta-analysis did not confirm any significant effect on serum concentration of IL-6 and TNF-α among post-menopausal women. SN - 1440-1681 UR - https://www.unboundmedicine.com/medline/citation/34455600/The_efficacy_of_soy_isoflavones_combined_with_soy_protein_on_serum_concentration_of_interleukin_6_and_tumour_necrosis_factor_α_among_post_menopausal_women_A_systematic_review_and_meta_analysis_of_randomized_controlled_trials_ L2 - https://doi.org/10.1111/1440-1681.13586 DB - PRIME DP - Unbound Medicine ER -