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Air pollution and the pandemic: Long-term PM2.5 exposure and disease severity in COVID-19 patients.
Respirology. 2021 12; 26(12):1181-1187.R

Abstract

BACKGROUND AND OBJECTIVE

Ecological studies have suggested an association between exposure to particulate matter ≤2.5 μm (PM2.5) and coronavirus disease 2019 (COVID-19) severity. However, these findings are yet to be validated in individual-level studies. We aimed to determine the association of long-term PM2.5 exposure with hospitalization among individual patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

METHODS

We estimated the 10-year (2009-2018) PM2.5 exposure at the residential zip code of COVID-19 patients diagnosed at the University of Cincinnati healthcare system between 13 March 2020 and 30 September 2020. Logistic regression was used to determine the odds ratio (OR) and 95% CI for COVID-19 hospitalizations associated with PM2.5 , adjusting for socioeconomic characteristics and comorbidities.

RESULTS

Among the 14,783 COVID-19 patients included in our study, 13.6% were hospitalized; the geometric mean (SD) PM2.5 was 10.48 (1.12) μg/m3 . In adjusted analysis, 1 μg/m3 increase in 10-year annual average PM2.5 was associated with 18% higher hospitalization (OR: 1.18, 95% CI: 1.11-1.26). Likewise, 1 μg/m3 increase in PM2.5 estimated for the year 2018 was associated with 14% higher hospitalization (OR: 1.14, 95% CI: 1.08-1.21).

CONCLUSION

Long-term PM2.5 exposure is associated with increased hospitalization in COVID-19. Therefore, more stringent COVID-19 prevention measures may be needed in areas with higher PM2.5 exposure to reduce the disease morbidity and healthcare burden.

Authors+Show Affiliations

Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.Center for Health Informatics, Department of Biomedical Informatics, College of Medicine, University of Cincinnati, Cincinnati, Ohio, USA.Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.Division of Infectious Diseases, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.Division of Asthma Research, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio, USA.Division of Biostatistics and Bioinformatics, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.Division of Epidemiology, Department of Environmental and Public Health Sciences, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

34459069

Citation

Mendy, Angelico, et al. "Air Pollution and the Pandemic: Long-term PM2.5 Exposure and Disease Severity in COVID-19 Patients." Respirology (Carlton, Vic.), vol. 26, no. 12, 2021, pp. 1181-1187.
Mendy A, Wu X, Keller JL, et al. Air pollution and the pandemic: Long-term PM2.5 exposure and disease severity in COVID-19 patients. Respirology. 2021;26(12):1181-1187.
Mendy, A., Wu, X., Keller, J. L., Fassler, C. S., Apewokin, S., Mersha, T. B., Xie, C., & Pinney, S. M. (2021). Air pollution and the pandemic: Long-term PM2.5 exposure and disease severity in COVID-19 patients. Respirology (Carlton, Vic.), 26(12), 1181-1187. https://doi.org/10.1111/resp.14140
Mendy A, et al. Air Pollution and the Pandemic: Long-term PM2.5 Exposure and Disease Severity in COVID-19 Patients. Respirology. 2021;26(12):1181-1187. PubMed PMID: 34459069.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Air pollution and the pandemic: Long-term PM2.5 exposure and disease severity in COVID-19 patients. AU - Mendy,Angelico, AU - Wu,Xiao, AU - Keller,Jason L, AU - Fassler,Cecily S, AU - Apewokin,Senu, AU - Mersha,Tesfaye B, AU - Xie,Changchun, AU - Pinney,Susan M, Y1 - 2021/08/30/ PY - 2021/07/09/revised PY - 2021/05/02/received PY - 2021/08/09/accepted PY - 2021/8/31/pubmed PY - 2021/11/23/medline PY - 2021/8/30/entrez KW - COVID-19 hospitalization KW - PM2.5 exposure KW - SARS-CoV-2 KW - air pollution KW - coronavirus disease SP - 1181 EP - 1187 JF - Respirology (Carlton, Vic.) JO - Respirology VL - 26 IS - 12 N2 - BACKGROUND AND OBJECTIVE: Ecological studies have suggested an association between exposure to particulate matter ≤2.5 μm (PM2.5) and coronavirus disease 2019 (COVID-19) severity. However, these findings are yet to be validated in individual-level studies. We aimed to determine the association of long-term PM2.5 exposure with hospitalization among individual patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: We estimated the 10-year (2009-2018) PM2.5 exposure at the residential zip code of COVID-19 patients diagnosed at the University of Cincinnati healthcare system between 13 March 2020 and 30 September 2020. Logistic regression was used to determine the odds ratio (OR) and 95% CI for COVID-19 hospitalizations associated with PM2.5 , adjusting for socioeconomic characteristics and comorbidities. RESULTS: Among the 14,783 COVID-19 patients included in our study, 13.6% were hospitalized; the geometric mean (SD) PM2.5 was 10.48 (1.12) μg/m3 . In adjusted analysis, 1 μg/m3 increase in 10-year annual average PM2.5 was associated with 18% higher hospitalization (OR: 1.18, 95% CI: 1.11-1.26). Likewise, 1 μg/m3 increase in PM2.5 estimated for the year 2018 was associated with 14% higher hospitalization (OR: 1.14, 95% CI: 1.08-1.21). CONCLUSION: Long-term PM2.5 exposure is associated with increased hospitalization in COVID-19. Therefore, more stringent COVID-19 prevention measures may be needed in areas with higher PM2.5 exposure to reduce the disease morbidity and healthcare burden. SN - 1440-1843 UR - https://www.unboundmedicine.com/medline/citation/34459069/Air_pollution_and_the_pandemic:_Long_term_PM2_5_exposure_and_disease_severity_in_COVID_19_patients_ L2 - https://doi.org/10.1111/resp.14140 DB - PRIME DP - Unbound Medicine ER -