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Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study.
BMC Cancer. 2021 Sep 01; 21(1):982.BC

Abstract

BACKGROUND

B vitamins and methionine are essential substrates in the one-carbon metabolism pathway involved in DNA synthesis and methylation. They may have essential roles in cancer development. We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study.

METHODS

We included 87,053 Japanese individuals who completed a food frequency questionnaire and were followed up from 1995-1998 to 2013 and 2015. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by Cox proportional-hazard regression across quintiles of dietary intakes of B vitamins and methionine.

RESULTS

After 1,456,678 person-years of follow-up, 427 EC cases were documented. The multivariable HR (95% CI) of incident EC in the highest versus lowest quintile of dietary intake of vitamin B12 was 1.75 (1.13-2.71; p-trend=0.01). Stratification analysis based on alcohol consumption showed that higher dietary intakes of vitamin B12 and methionine were associated with an increased risk of EC among never-drinkers; HRs (95% CIs) were 2.82 (1.18-6.74; p-trend=0.009; p-interaction=0.18) and 3.45 (1.32-9.06; p-trend=0.003; p-interaction 0.02) for vitamin B12 and methionine, respectively. Meanwhile, there was no association between vitamin B12 and methionine intake with the risk of EC among drinkers. There were no associations between dietary intake of folate or vitamin B6 and the risk of EC.

CONCLUSION

Dietary intake of vitamin B12 was positively associated with the risk of EC in the Japanese population.

Links

Authors+Show Affiliations

Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. Department of Internal Medicine, Faculty of Medicine, University of Muhammadiyah, Jakarta, Indonesia.

Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan. tsobue@envi.med.osaka-u.ac.jp.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan. Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minya, Egypt.

Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka, 565-0871, Japan.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Chuo-ku Tokyo, 104-0045, Japan.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Chuo-ku Tokyo, 104-0045, Japan.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Chuo-ku Tokyo, 104-0045, Japan.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Chuo-ku Tokyo, 104-0045, Japan.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Chuo-ku Tokyo, 104-0045, Japan.

Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, 565-0871, Japan.

Epidemiology and Prevention Group, Center for Public Health Sciences, National Cancer Center, Chuo-ku Tokyo, 104-0045, Japan.

MeSH

AgedAlcohol DrinkingEatingEsophageal NeoplasmsFemaleFolic AcidFollow-Up StudiesHumansJapanMaleMethionineMiddle AgedPrognosisProspective StudiesPublic HealthRisk FactorsVitamin B 12Vitamin B 6Vitamins

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34470601

Citation

Khairan, Paramita, et al. "Association of Dietary Intakes of Vitamin B12, Vitamin B6, Folate, and Methionine With the Risk of Esophageal Cancer: the Japan Public Health Center-based (JPHC) Prospective Study." BMC Cancer, vol. 21, no. 1, 2021, p. 982.

Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer. 2021;21(1):982.

Khairan, P., Sobue, T., Eshak, E. S., Zha, L., Kitamura, T., Sawada, N., Iwasaki, M., Inoue, M., Yamaji, T., Shimazu, T., Iso, H., & Tsugane, S. (2021). Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer, 21(1), 982. https://doi.org/10.1186/s12885-021-08721-8

Khairan P, et al. Association of Dietary Intakes of Vitamin B12, Vitamin B6, Folate, and Methionine With the Risk of Esophageal Cancer: the Japan Public Health Center-based (JPHC) Prospective Study. BMC Cancer. 2021 Sep 1;21(1):982. PubMed PMID: 34470601.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. AU - Khairan,Paramita, AU - Sobue,Tomotaka, AU - Eshak,Ehab Salah, AU - Zha,Ling, AU - Kitamura,Tetsuhisa, AU - Sawada,Norie, AU - Iwasaki,Motoki, AU - Inoue,Manami, AU - Yamaji,Taiki, AU - Shimazu,Taichi, AU - Iso,Hiroyasu, AU - Tsugane,Shoichiro, Y1 - 2021/09/01/ PY - 2021/04/08/received PY - 2021/08/18/accepted PY - 2021/9/2/entrez PY - 2021/9/3/pubmed PY - 2021/10/21/medline KW - Esophageal cancer KW - Folate intake KW - One-carbon metabolism KW - Prospective cohort study KW - Vitamin B12 intake SP - 982 EP - 982 JF - BMC cancer JO - BMC Cancer VL - 21 IS - 1 N2 - BACKGROUND: B vitamins and methionine are essential substrates in the one-carbon metabolism pathway involved in DNA synthesis and methylation. They may have essential roles in cancer development. We aimed to evaluate the associations of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer (EC) using data from the Japan Public Health Center-based Prospective Study. METHODS: We included 87,053 Japanese individuals who completed a food frequency questionnaire and were followed up from 1995-1998 to 2013 and 2015. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated by Cox proportional-hazard regression across quintiles of dietary intakes of B vitamins and methionine. RESULTS: After 1,456,678 person-years of follow-up, 427 EC cases were documented. The multivariable HR (95% CI) of incident EC in the highest versus lowest quintile of dietary intake of vitamin B12 was 1.75 (1.13-2.71; p-trend=0.01). Stratification analysis based on alcohol consumption showed that higher dietary intakes of vitamin B12 and methionine were associated with an increased risk of EC among never-drinkers; HRs (95% CIs) were 2.82 (1.18-6.74; p-trend=0.009; p-interaction=0.18) and 3.45 (1.32-9.06; p-trend=0.003; p-interaction 0.02) for vitamin B12 and methionine, respectively. Meanwhile, there was no association between vitamin B12 and methionine intake with the risk of EC among drinkers. There were no associations between dietary intake of folate or vitamin B6 and the risk of EC. CONCLUSION: Dietary intake of vitamin B12 was positively associated with the risk of EC in the Japanese population. SN - 1471-2407 UR - https://www.unboundmedicine.com/medline/citation/34470601/Association_of_dietary_intakes_of_vitamin_B12_vitamin_B6_folate_and_methionine_with_the_risk_of_esophageal_cancer:_the_Japan_Public_Health_Center_based__JPHC__prospective_study_ DB - PRIME DP - Unbound Medicine ER -