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FKBP51 and the molecular chaperoning of metabolism.
Trends Endocrinol Metab. 2021 11; 32(11):862-874.TE

Abstract

The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism.

Authors+Show Affiliations

Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA.Center for Diabetes and Endocrine Research, Department of Physiology and Pharmacology, University of Toledo College of Medicine, Toledo, OH 43614, USA.Barnstable Brown Diabetes Center, Markey Cancer Center, Department of Pharmacology and Nutritional Sciences, University of Kentucky College of Medicine, Lexington, KY 40508, USA. Electronic address: terry.hinds@uky.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

34481731

Citation

Smedlund, Kathryn B., et al. "FKBP51 and the Molecular Chaperoning of Metabolism." Trends in Endocrinology and Metabolism: TEM, vol. 32, no. 11, 2021, pp. 862-874.
Smedlund KB, Sanchez ER, Hinds TD. FKBP51 and the molecular chaperoning of metabolism. Trends Endocrinol Metab. 2021;32(11):862-874.
Smedlund, K. B., Sanchez, E. R., & Hinds, T. D. (2021). FKBP51 and the molecular chaperoning of metabolism. Trends in Endocrinology and Metabolism: TEM, 32(11), 862-874. https://doi.org/10.1016/j.tem.2021.08.003
Smedlund KB, Sanchez ER, Hinds TD. FKBP51 and the Molecular Chaperoning of Metabolism. Trends Endocrinol Metab. 2021;32(11):862-874. PubMed PMID: 34481731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - FKBP51 and the molecular chaperoning of metabolism. AU - Smedlund,Kathryn B, AU - Sanchez,Edwin R, AU - Hinds,Terry D,Jr Y1 - 2021/09/01/ PY - 2021/07/06/received PY - 2021/07/31/revised PY - 2021/08/06/accepted PY - 2021/9/6/pubmed PY - 2022/4/28/medline PY - 2021/9/5/entrez KW - AKT KW - FKBP4 KW - FKBP5 KW - adipose KW - diabetes KW - obesity SP - 862 EP - 874 JF - Trends in endocrinology and metabolism: TEM JO - Trends Endocrinol Metab VL - 32 IS - 11 N2 - The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a meaningful biomarker of metabolic dysfunction. This review examines the emerging contributions of FKBP51 in adipogenesis and lipid metabolism, myogenesis and protein catabolism, and glucocorticoid-induced skin hypoplasia and dermal adipocytes. The FKBP51 signaling mechanisms that may explain these metabolic consequences are discussed. These mechanisms are diverse, with FKBP51 independently and directly regulating phosphorylation cascades and nuclear receptors. We provide a discussion of the newly developed compounds that antagonize FKBP51, which may offer therapeutic advantages for adiposity. These observations suggest we are only beginning to uncover the complex nature of FKBP51 and its molecular chaperoning of metabolism. SN - 1879-3061 UR - https://www.unboundmedicine.com/medline/citation/34481731/FKBP51_and_the_molecular_chaperoning_of_metabolism_ DB - PRIME DP - Unbound Medicine ER -