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Gas chromatographic--mass spectrometric determination of haloperidol in plasma. Application to pharmacokinetics.
Arzneimittelforschung. 1987 Dec; 37(12):1402-4.A

Abstract

An improved gas chromatographic-mass spectrometric chemical ionization assay for the quantitative determination of haloperidol in body fluids is presented. A fused silica, bonded phase capillary column, combined with negative ion chemical ionization (NICI), ammonia as a selective reagent gas and the monitoring of preselected characteristic ions (SIM), provide the combined sensitivity and selectivity necessary for reliable measurements in the low ng/ml range. The lower limit of detection was 0.1 ng/ml plasma and the calibration curve linear in the measured range of 0.1-5 ng/ml. In combination with the excellent imprecision and inaccuracy data and a recovery exceeding 90%, the method is very well suited for quantitative determinations of plasma samples generated during clinical studies, e.g. evaluating the pharmacokinetics and/or bioavailability/bioequivalence of haloperidol.

Authors+Show Affiliations

Analytical Research Centre, LAB GmbH, Neu-Ulm, Fed. Rep. of Germany.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

3449072

Citation

Häring, N, et al. "Gas Chromatographic--mass Spectrometric Determination of Haloperidol in Plasma. Application to Pharmacokinetics." Arzneimittel-Forschung, vol. 37, no. 12, 1987, pp. 1402-4.
Häring N, Salama Z, Todesko L, et al. Gas chromatographic--mass spectrometric determination of haloperidol in plasma. Application to pharmacokinetics. Arzneimittelforschung. 1987;37(12):1402-4.
Häring, N., Salama, Z., Todesko, L., & Jaeger, H. (1987). Gas chromatographic--mass spectrometric determination of haloperidol in plasma. Application to pharmacokinetics. Arzneimittel-Forschung, 37(12), 1402-4.
Häring N, et al. Gas Chromatographic--mass Spectrometric Determination of Haloperidol in Plasma. Application to Pharmacokinetics. Arzneimittelforschung. 1987;37(12):1402-4. PubMed PMID: 3449072.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gas chromatographic--mass spectrometric determination of haloperidol in plasma. Application to pharmacokinetics. AU - Häring,N, AU - Salama,Z, AU - Todesko,L, AU - Jaeger,H, PY - 1987/12/1/pubmed PY - 1987/12/1/medline PY - 1987/12/1/entrez SP - 1402 EP - 4 JF - Arzneimittel-Forschung JO - Arzneimittelforschung VL - 37 IS - 12 N2 - An improved gas chromatographic-mass spectrometric chemical ionization assay for the quantitative determination of haloperidol in body fluids is presented. A fused silica, bonded phase capillary column, combined with negative ion chemical ionization (NICI), ammonia as a selective reagent gas and the monitoring of preselected characteristic ions (SIM), provide the combined sensitivity and selectivity necessary for reliable measurements in the low ng/ml range. The lower limit of detection was 0.1 ng/ml plasma and the calibration curve linear in the measured range of 0.1-5 ng/ml. In combination with the excellent imprecision and inaccuracy data and a recovery exceeding 90%, the method is very well suited for quantitative determinations of plasma samples generated during clinical studies, e.g. evaluating the pharmacokinetics and/or bioavailability/bioequivalence of haloperidol. SN - 0004-4172 UR - https://www.unboundmedicine.com/medline/citation/3449072/Gas_chromatographic__mass_spectrometric_determination_of_haloperidol_in_plasma__Application_to_pharmacokinetics_ DB - PRIME DP - Unbound Medicine ER -