TY - JOUR T1 - Apalutamide-associated skin rash in patients with prostate cancer: Histological evaluation by skin biopsy. AU - Tohi,Yoichiro, AU - Kataoka,Koki, AU - Miyai,Yumi, AU - Kaku,Yo, AU - Dainichi,Teruki, AU - Haba,Reiji, AU - Tsunemori,Hiroyuki, AU - Sugimoto,Mikio, Y1 - 2021/06/27/ PY - 2021/04/27/received PY - 2021/06/07/accepted PY - 2021/9/9/entrez PY - 2021/9/10/pubmed PY - 2021/9/10/medline KW - adverse event KW - apalutamide KW - eczematous drug eruption KW - prostate cancer KW - skin rash SP - 299 EP - 302 JF - IJU case reports JO - IJU Case Rep VL - 4 IS - 5 N2 - INTRODUCTION: Apalutamide-associated skin rash is a more common adverse event in the Japanese population than in the global population. However, its mechanism remains elusive, and limited histopathological information hampers further understanding. CASE PRESENTATION: Case 1: a 71-year-old man with metastatic castration-sensitive prostate cancer developed a skin rash after 70 days of apalutamide treatment. Case 2: a 71-year-old man with non-metastatic castration-resistant prostate cancer developed a skin rash after 71 days of apalutamide treatment. In both cases, the skin rash presented as a slightly exudative erythema. The histology showed spongiosis of the epidermis and perivascular and interstitial infiltration of lymphocytes and eosinophils in the upper dermis without necrotic keratinocytes. CONCLUSION: Apalutamide-induced skin rashes can involve an eczematous reaction clinically and histologically. SN - 2577-171X UR - https://www.unboundmedicine.com/medline/citation/34497989/Apalutamide_associated_skin_rash_in_patients_with_prostate_cancer:_Histological_evaluation_by_skin_biopsy_ DB - PRIME DP - Unbound Medicine ER -