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Predominant frequency of HLA-B*27 in patients with ankylosing spondylitis in southeastern China.
Immun Inflamm Dis. 2021 12; 9(4):1696-1701.II

Abstract

OBJECTIVES

This study was to investigate the polymorphism and distribution of alleles of HLA-B*27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China.

METHODS

A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnosed according to Modified New York criteria were subtyped using the high-resolution PCR-SSP.Exon 2-3 of HLA-B*27 gene was amplified and sequenced to further confirm the HLA-B*27 subtype.

RESULTS

The frequency of HLA-B*27 was 99.87% in AS patients. Three subtypes, HLA-B*2704, HLA-B*2705, and HLA-B*2706 were identified. The frequencies for these three alleles were HLA-B*2704 in 84/88 (95.46%), HLA-B*2705 in 3/88(3.41%), and HLA-B*2706 in 1/88 (1.13%) of the HLA-B*27 positive patients, respectively.

CONCLUSIONS

Our study shows that HLA-B*2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA-B*27-subtype distributions in Chinese Han populations showed that HLA-B*2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA-B*2705 show the opposite result.

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Authors+Show Affiliations

Department of Central Laboratory, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

Department of Central Laboratory, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

Department of Central Laboratory, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

Department of Clinical Laboratory, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

Department of Central Laboratory, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

Department of Traditional Chinese Medicine, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

Department of Traditional Chinese Medicine, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

Department of Central Laboratory, Ningde Municipal Hospital Affiliated to Ningde Normal University, Ningde, Fujian, China.

MeSH

AllelesAsian PeopleChinaHLA-B27 AntigenHumansPolymorphism, GeneticSpondylitis, Ankylosing

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34499816

Citation

Lu, JiaoJiao, et al. "Predominant Frequency of HLA-B*27 in Patients With Ankylosing Spondylitis in Southeastern China." Immunity, Inflammation and Disease, vol. 9, no. 4, 2021, pp. 1696-1701.

Lu J, Yang J, Dong W, et al. Predominant frequency of HLA-B*27 in patients with ankylosing spondylitis in southeastern China. Immun Inflamm Dis. 2021;9(4):1696-1701.

Lu, J., Yang, J., Dong, W., Tang, B., Cao, L., Lin, Y., Huang, B., & Fu, X. (2021). Predominant frequency of HLA-B*27 in patients with ankylosing spondylitis in southeastern China. Immunity, Inflammation and Disease, 9(4), 1696-1701. https://doi.org/10.1002/iid3.524

Lu J, et al. Predominant Frequency of HLA-B*27 in Patients With Ankylosing Spondylitis in Southeastern China. Immun Inflamm Dis. 2021;9(4):1696-1701. PubMed PMID: 34499816.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Predominant frequency of HLA-B*27 in patients with ankylosing spondylitis in southeastern China. AU - Lu,JiaoJiao, AU - Yang,Jing, AU - Dong,WenXu, AU - Tang,BaoJia, AU - Cao,LuoYuan, AU - Lin,YingHua, AU - Huang,BaoYing, AU - Fu,XianGuo, Y1 - 2021/09/09/ PY - 2021/08/24/revised PY - 2021/07/26/received PY - 2021/08/26/accepted PY - 2021/9/10/pubmed PY - 2021/12/15/medline PY - 2021/9/9/entrez KW - HLA-B*27 KW - ankylosing spondylitis KW - high-resolution PCR-SSP KW - subtypes SP - 1696 EP - 1701 JF - Immunity, inflammation and disease JO - Immun Inflamm Dis VL - 9 IS - 4 N2 - OBJECTIVES: This study was to investigate the polymorphism and distribution of alleles of HLA-B*27 in patients with ankylosing spondylitis (AS) in Han population of southeastern China. METHODS: A total of 89 peripheral blood samples from southeastern Chinese Han patients with AS that diagnosed according to Modified New York criteria were subtyped using the high-resolution PCR-SSP.Exon 2-3 of HLA-B*27 gene was amplified and sequenced to further confirm the HLA-B*27 subtype. RESULTS: The frequency of HLA-B*27 was 99.87% in AS patients. Three subtypes, HLA-B*2704, HLA-B*2705, and HLA-B*2706 were identified. The frequencies for these three alleles were HLA-B*2704 in 84/88 (95.46%), HLA-B*2705 in 3/88(3.41%), and HLA-B*2706 in 1/88 (1.13%) of the HLA-B*27 positive patients, respectively. CONCLUSIONS: Our study shows that HLA-B*2704 has an overwhelming frequency in southeastern Chinese Han AS patients. A combined analysis including previous studies of HLA-B*27-subtype distributions in Chinese Han populations showed that HLA-B*2704 may originate from the southern Han and then migrate and spread to the northern areas, and HLA-B*2705 show the opposite result. SN - 2050-4527 UR - https://www.unboundmedicine.com/medline/citation/34499816/Predominant_frequency_of_HLA_B_27_in_patients_with_ankylosing_spondylitis_in_southeastern_China_ DB - PRIME DP - Unbound Medicine ER -