Tags

Type your tag names separated by a space and hit enter

Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges.
Molecules. 2021 Sep 02; 26(17)M

Abstract

Natural products derived from plants, as well as their bioactive compounds, have been extensively studied in recent years for their therapeutic potential in a variety of neurodegenerative diseases (NDs), including Alzheimer's (AD), Huntington's (HD), and Parkinson's (PD) disease. These diseases are characterized by progressive dysfunction and loss of neuronal structure and function. There has been little progress in designing efficient treatments, despite impressive breakthroughs in our understanding of NDs. In the prevention and therapy of NDs, the use of natural products may provide great potential opportunities; however, many clinical issues have emerged regarding their use, primarily based on the lack of scientific support or proof of their effectiveness and patient safety. Since neurodegeneration is associated with a myriad of pathological processes, targeting multi-mechanisms of action and neuroprotection approaches that include preventing cell death and restoring the function of damaged neurons should be employed. In the treatment of NDs, including AD and PD, natural products have emerged as potential neuroprotective agents. This current review will highlight the therapeutic potential of numerous natural products and their bioactive compounds thatexert neuroprotective effects on the pathologies of NDs.

Authors+Show Affiliations

Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea. Department of Global Medical Science, Yonsei University Graduate School, Wonju 26426, Gangwon-do, Korea.Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea.Department of Laboratory Medicine, Yonsei University Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea.Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea. Department of Global Medical Science, Yonsei University Graduate School, Wonju 26426, Gangwon-do, Korea.Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea. Department of Global Medical Science, Yonsei University Graduate School, Wonju 26426, Gangwon-do, Korea.Department of Global Medical Science, Yonsei University Graduate School, Wonju 26426, Gangwon-do, Korea.Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea.Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea.Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea.Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju 26426, Gangwon-do, Korea.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34500759

Citation

Rahman, Md Habibur, et al. "Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges." Molecules (Basel, Switzerland), vol. 26, no. 17, 2021.
Rahman MH, Bajgai J, Fadriquela A, et al. Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules. 2021;26(17).
Rahman, M. H., Bajgai, J., Fadriquela, A., Sharma, S., Trinh, T. T., Akter, R., Jeong, Y. J., Goh, S. H., Kim, C. S., & Lee, K. J. (2021). Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules (Basel, Switzerland), 26(17). https://doi.org/10.3390/molecules26175327
Rahman MH, et al. Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. Molecules. 2021 Sep 2;26(17) PubMed PMID: 34500759.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Therapeutic Potential of Natural Products in Treating Neurodegenerative Disorders and Their Future Prospects and Challenges. AU - Rahman,Md Habibur, AU - Bajgai,Johny, AU - Fadriquela,Ailyn, AU - Sharma,Subham, AU - Trinh,Thuy Thi, AU - Akter,Rokeya, AU - Jeong,Yun Ju, AU - Goh,Seong Hoon, AU - Kim,Cheol-Su, AU - Lee,Kyu-Jae, Y1 - 2021/09/02/ PY - 2021/07/29/received PY - 2021/08/25/revised PY - 2021/08/27/accepted PY - 2021/9/10/entrez PY - 2021/9/11/pubmed PY - 2021/11/11/medline KW - alzheimer’s disease KW - natural products KW - neurodegenerative diseases KW - neuroinflammation KW - oxidative stress KW - parkinson’s disease KW - therapeutic potential JF - Molecules (Basel, Switzerland) JO - Molecules VL - 26 IS - 17 N2 - Natural products derived from plants, as well as their bioactive compounds, have been extensively studied in recent years for their therapeutic potential in a variety of neurodegenerative diseases (NDs), including Alzheimer's (AD), Huntington's (HD), and Parkinson's (PD) disease. These diseases are characterized by progressive dysfunction and loss of neuronal structure and function. There has been little progress in designing efficient treatments, despite impressive breakthroughs in our understanding of NDs. In the prevention and therapy of NDs, the use of natural products may provide great potential opportunities; however, many clinical issues have emerged regarding their use, primarily based on the lack of scientific support or proof of their effectiveness and patient safety. Since neurodegeneration is associated with a myriad of pathological processes, targeting multi-mechanisms of action and neuroprotection approaches that include preventing cell death and restoring the function of damaged neurons should be employed. In the treatment of NDs, including AD and PD, natural products have emerged as potential neuroprotective agents. This current review will highlight the therapeutic potential of numerous natural products and their bioactive compounds thatexert neuroprotective effects on the pathologies of NDs. SN - 1420-3049 UR - https://www.unboundmedicine.com/medline/citation/34500759/Therapeutic_Potential_of_Natural_Products_in_Treating_Neurodegenerative_Disorders_and_Their_Future_Prospects_and_Challenges_ DB - PRIME DP - Unbound Medicine ER -