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Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful?
Biomark Med. 2021 10; 15(15):1377-1388.BM

Abstract

Aim: The aim of our work is to aggregate data from publications of cerebrospinal fluid extracellular miRNA to identify candidate diagnostic biomarkers, and those warranting further study. Materials & methods: Data were pooled from nine studies, encompassing 864 patients across 16 diseases. Unsupervised clustering grouped patients by a broad category of diseases. Results & conclusion: Compared with healthy controls, in patients with Alzheimer's disease, hsa-miR-767-5p was overexpressed (p < 0.001) and in patients with Huntington's disease, hsa-miR-361-3p was underexpressed (p < 10-4). We also define a subset of extracellular miRNA as candidate biomarkers that are robustly detected across patients, studies and diseases; thereby, warranting further study.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Dhawan A
Department of Neurology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, OH, 44195, USA.

MeSH

AdultAgedAlzheimer DiseaseAmyotrophic Lateral SclerosisBiomarkersCluster AnalysisFemaleGene Expression ProfilingGene Regulatory NetworksHumansHuntington DiseaseMaleMicroRNAsMiddle AgedNeurodegenerative DiseasesParkinson Disease

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34514843

Citation

Dhawan, Andrew. "Extracellular miRNA Biomarkers in Neurologic Disease: Is Cerebrospinal Fluid Helpful?" Biomarkers in Medicine, vol. 15, no. 15, 2021, pp. 1377-1388.
Dhawan A. Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful? Biomark Med. 2021;15(15):1377-1388.
Dhawan, A. (2021). Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful? Biomarkers in Medicine, 15(15), 1377-1388. https://doi.org/10.2217/bmm-2021-0092
Dhawan A. Extracellular miRNA Biomarkers in Neurologic Disease: Is Cerebrospinal Fluid Helpful. Biomark Med. 2021;15(15):1377-1388. PubMed PMID: 34514843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Extracellular miRNA biomarkers in neurologic disease: is cerebrospinal fluid helpful? A1 - Dhawan,Andrew, Y1 - 2021/09/13/ PY - 2021/9/14/pubmed PY - 2022/3/22/medline PY - 2021/9/13/entrez KW - Alzheimer’s disease KW - Parkinson’s disease KW - diagnostics KW - neurology KW - translational medicine SP - 1377 EP - 1388 JF - Biomarkers in medicine JO - Biomark Med VL - 15 IS - 15 N2 - Aim: The aim of our work is to aggregate data from publications of cerebrospinal fluid extracellular miRNA to identify candidate diagnostic biomarkers, and those warranting further study. Materials & methods: Data were pooled from nine studies, encompassing 864 patients across 16 diseases. Unsupervised clustering grouped patients by a broad category of diseases. Results & conclusion: Compared with healthy controls, in patients with Alzheimer's disease, hsa-miR-767-5p was overexpressed (p < 0.001) and in patients with Huntington's disease, hsa-miR-361-3p was underexpressed (p < 10-4). We also define a subset of extracellular miRNA as candidate biomarkers that are robustly detected across patients, studies and diseases; thereby, warranting further study. SN - 1752-0371 UR - https://www.unboundmedicine.com/medline/citation/34514843/Extracellular_miRNA_biomarkers_in_neurologic_disease:_is_cerebrospinal_fluid_helpful DB - PRIME DP - Unbound Medicine ER -