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The prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis.
PLoS One. 2021; 16(9):e0257630.Plos

Abstract

INTRODUCTION

Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia among HIV/AIDS patients.

METHODS

This systematic review and meta-analysis was conducted following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. A systematic search was conducted from February 01, 2021 to April 02, 2021 using electronic databases Google Scholar, PubMed, Web of Sciences, Google, EMBASE, SCOPUS and ResearchGate. The quality of the included studies was assessed using Newcastle-Ottawa Quality Assessment Scale (NOS) adapted for cross-sectional studies. Data analysis was done using STATA version 14 using metan commands. Random effect meta-analysis was used to estimate the pooled prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia.

RESULT

Of the 349 initially searched articles, 90 were assessed for eligibility and only 13 articles published from 2014 to 2020 were included in the final meta-analysis. A total of 3854 participants were involved in the included studies. The pooled prevalence of thrombocytopenia was 9.69% (95%CI; 7.40-11.97%). Significant heterogeneity was observed with I2 value of 84.7%. Thrombocytopenia was 11.91% and 5.95% prevalent among HAART naive and HAART exposed HIV/AIDS patients, respectively. The pooled prevalence of leucopenia among HIV/AIDS patients was 17.31% (95%CI: 12.37-22.25%).

CONCLUSION

This study showed a high prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS, indicating the necessity of regular screening of HIV seropositive patients for different hematological parameters and providing treatment.

Links

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Authors+Show Affiliations

Bisetegn H
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.
Ebrahim H
Department of Medical Laboratory Sciences, College of Medicine and Health Sciences, Wollo University, Dessie, Ethiopia.

MeSH

Acquired Immunodeficiency SyndromeAntiretroviral Therapy, Highly ActiveDatabases, FactualEthiopiaHIV InfectionsHumansLeukopeniaThrombocytopenia

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

34543340

Citation

Bisetegn, Habtye, and Hussien Ebrahim. "The Prevalence of Thrombocytopenia and Leucopenia Among People Living With HIV/AIDS in Ethiopia: a Systematic Review and Meta-analysis." PloS One, vol. 16, no. 9, 2021, pp. e0257630.
Bisetegn H, Ebrahim H. The prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis. PLoS One. 2021;16(9):e0257630.
Bisetegn, H., & Ebrahim, H. (2021). The prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis. PloS One, 16(9), e0257630. https://doi.org/10.1371/journal.pone.0257630
Bisetegn H, Ebrahim H. The Prevalence of Thrombocytopenia and Leucopenia Among People Living With HIV/AIDS in Ethiopia: a Systematic Review and Meta-analysis. PLoS One. 2021;16(9):e0257630. PubMed PMID: 34543340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia: A systematic review and meta-analysis. AU - Bisetegn,Habtye, AU - Ebrahim,Hussien, Y1 - 2021/09/20/ PY - 2021/04/26/received PY - 2021/09/05/accepted PY - 2021/9/20/entrez PY - 2021/9/21/pubmed PY - 2021/11/24/medline SP - e0257630 EP - e0257630 JF - PloS one JO - PLoS One VL - 16 IS - 9 N2 - INTRODUCTION: Thrombocytopenia and leucopenia are frequently encountered hematological disorders among people living with HIV/AIDS. This systematic review and meta-analysis were aimed to indicate the national prevalence of thrombocytopenia and leucopenia among HIV/AIDS patients. METHODS: This systematic review and meta-analysis was conducted following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. A systematic search was conducted from February 01, 2021 to April 02, 2021 using electronic databases Google Scholar, PubMed, Web of Sciences, Google, EMBASE, SCOPUS and ResearchGate. The quality of the included studies was assessed using Newcastle-Ottawa Quality Assessment Scale (NOS) adapted for cross-sectional studies. Data analysis was done using STATA version 14 using metan commands. Random effect meta-analysis was used to estimate the pooled prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS in Ethiopia. RESULT: Of the 349 initially searched articles, 90 were assessed for eligibility and only 13 articles published from 2014 to 2020 were included in the final meta-analysis. A total of 3854 participants were involved in the included studies. The pooled prevalence of thrombocytopenia was 9.69% (95%CI; 7.40-11.97%). Significant heterogeneity was observed with I2 value of 84.7%. Thrombocytopenia was 11.91% and 5.95% prevalent among HAART naive and HAART exposed HIV/AIDS patients, respectively. The pooled prevalence of leucopenia among HIV/AIDS patients was 17.31% (95%CI: 12.37-22.25%). CONCLUSION: This study showed a high prevalence of thrombocytopenia and leucopenia among people living with HIV/AIDS, indicating the necessity of regular screening of HIV seropositive patients for different hematological parameters and providing treatment. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/34543340/The_prevalence_of_thrombocytopenia_and_leucopenia_among_people_living_with_HIV/AIDS_in_Ethiopia:_A_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -