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Can Anakinra and corticosteroid treatment be an effective option in pregnant women with severe Covid-19?
Women Health. 2021 Sep 22 [Online ahead of print]WH

Abstract

Anakinra, which is an Interleukin-1 (IL-1) receptor antagonist with the advancing disease process, has started to be considered as an alternative treatment for Covid-19 patients with cytokine storms. We evaluated the effect of corticosteroids and IL-1 receptor blockage with anakinra on pregnant patients with Covid-19 at high risk for respiratory distress, ongoing fever, deterioration in their general condition and consequently maternal and fetal complications. Fourteen pregnant women who received anakinra (median dosage: 400 mg) and corticosteroid (methylprednisolone-median dosage: 80 mg) treatment were evaluated retrospectively. Patients were assessed according to the World Health Organization (WHO) scale. The mortality rate of the cohort was 7.1%, the median hospitalization period of the patients was 15 days and 2 patients had premature births. Covid-19 was found to have a similar spectrum of symptoms in pregnant and non-pregnant women, such as dyspnea, cough and fever. Our study was the first to analyze the combined treatment of corticosteroid and anakinra in pregnant patients with pneumonia from Covid-19 based on the WHO scoring system. Due to the obscurity in the treatment process in pregnant patients, studies are ongoing on managing Covid-19 infection in these patients. We presume that the early use of anakinra and corticosteroid treatments in patients severely infected with Covid-19 may have positive effects on disease progression and survival.

Authors+Show Affiliations

Department of Internal Medicine, Division of Rheumatology, Ankara City Hospital, Ankara, Turkey.Department of Internal Medicine, Division of Rheumatology, Ankara City Hospital, Ankara, Turkey.Department of Infectious Diseases, Ankara City Hospital, Ankara, Turkey.Department of Obstetrics and Gynecology, Ankara City Hospital, Ankara, Turkey.Department of Obstetrics and Gynecology, Ankara City Hospital, Ankara, Turkey.Department of Internal Medicine, Division of Rheumatology, Ankara City Hospital, Ankara, Turkey.Department of Obstetrics and Gynecology, Ankara City Hospital, Ankara, Turkey.Department of Obstetrics and Gynecology, Ankara City Hospital, Ankara, Turkey.Department of Internal Medicine, Ankara City Hospital, Ankara, Turkey.Department of Obstetrics and Gynecology, Turkish Ministry of Health, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.Department of Internal Medicine, Division of Rheumatology, Ankara City Hospital, Ankara, Turkey.Department of Obstetrics and Gynecology, Turkish Ministry of Health, Ankara City Hospital, University of Health Sciences, Ankara, Turkey.Department of Internal Medicine, Division of Rheumatology, Ankara City Hospital, Yıldırım Beyazıt University, Ankara, Turkey.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34551674

Citation

Karakaş, Özlem, et al. "Can Anakinra and Corticosteroid Treatment Be an Effective Option in Pregnant Women With Severe Covid-19?" Women & Health, 2021, pp. 1-8.
Karakaş Ö, Erden A, Ünlü S, et al. Can Anakinra and corticosteroid treatment be an effective option in pregnant women with severe Covid-19? Women Health. 2021.
Karakaş, Ö., Erden, A., Ünlü, S., Erol, S. A., Goncu Ayhan, Ş., Özdemir, B., Tanacan, A., Ozden Tokalioglu, E., Ateş, İ., Moraloğlu Tekin, Ö., Omma, A., Şahin, D., & Küçükşahin, O. (2021). Can Anakinra and corticosteroid treatment be an effective option in pregnant women with severe Covid-19? Women & Health, 1-8. https://doi.org/10.1080/03630242.2021.1981517
Karakaş Ö, et al. Can Anakinra and Corticosteroid Treatment Be an Effective Option in Pregnant Women With Severe Covid-19. Women Health. 2021 Sep 22;1-8. PubMed PMID: 34551674.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can Anakinra and corticosteroid treatment be an effective option in pregnant women with severe Covid-19? AU - Karakaş,Özlem, AU - Erden,Abdulsamet, AU - Ünlü,Serpil, AU - Erol,Seyit Ahmet, AU - Goncu Ayhan,Şule, AU - Özdemir,Bahar, AU - Tanacan,Atakan, AU - Ozden Tokalioglu,Eda, AU - Ateş,İhsan, AU - Moraloğlu Tekin,Özlem, AU - Omma,Ahmet, AU - Şahin,Dilek, AU - Küçükşahin,Orhan, Y1 - 2021/09/22/ PY - 2021/9/23/entrez PY - 2021/9/24/pubmed PY - 2021/9/24/medline KW - Anakinra KW - Covid-19 KW - corticosteroid KW - cytokine storm KW - methylprednisolone KW - pregnant SP - 1 EP - 8 JF - Women & health JO - Women Health N2 - Anakinra, which is an Interleukin-1 (IL-1) receptor antagonist with the advancing disease process, has started to be considered as an alternative treatment for Covid-19 patients with cytokine storms. We evaluated the effect of corticosteroids and IL-1 receptor blockage with anakinra on pregnant patients with Covid-19 at high risk for respiratory distress, ongoing fever, deterioration in their general condition and consequently maternal and fetal complications. Fourteen pregnant women who received anakinra (median dosage: 400 mg) and corticosteroid (methylprednisolone-median dosage: 80 mg) treatment were evaluated retrospectively. Patients were assessed according to the World Health Organization (WHO) scale. The mortality rate of the cohort was 7.1%, the median hospitalization period of the patients was 15 days and 2 patients had premature births. Covid-19 was found to have a similar spectrum of symptoms in pregnant and non-pregnant women, such as dyspnea, cough and fever. Our study was the first to analyze the combined treatment of corticosteroid and anakinra in pregnant patients with pneumonia from Covid-19 based on the WHO scoring system. Due to the obscurity in the treatment process in pregnant patients, studies are ongoing on managing Covid-19 infection in these patients. We presume that the early use of anakinra and corticosteroid treatments in patients severely infected with Covid-19 may have positive effects on disease progression and survival. SN - 1541-0331 UR - https://www.unboundmedicine.com/medline/citation/34551674/Can_Anakinra_and_corticosteroid_treatment_be_an_effective_option_in_pregnant_women_with_severe_Covid_19 L2 - https://www.tandfonline.com/doi/full/10.1080/03630242.2021.1981517 DB - PRIME DP - Unbound Medicine ER -
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