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Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease.
Nutrients. 2021 Sep 19; 13(9)N

Abstract

Chronic kidney disease affects ~37 million adults in the US, and it is often undiagnosed due to a lack of apparent symptoms in early stages. Chronic kidney disease (CKD) interferes with the body's physiological and biological mechanisms, such as fluid electrolyte and pH balance, blood pressure regulation, excretion of toxins and waste, vitamin D metabolism, and hormonal regulation. Many CKD patients are at risk of hyperkalemia, hyperphosphatemia, chronic metabolic acidosis, bone deterioration, blood pressure abnormalities, and edema. These risks may be minimized, and the disease's progression may be slowed through careful monitoring of protein, phosphorus, potassium, sodium, and calcium, relieving symptoms experienced by CKD patients. In this review, the current Kidney Disease Outcomes Quality Initiative (KDOQI) recommendations are highlighted, reflecting the 2020 update, including explanations for the pathophysiology behind the recommendations. The Dietary Approaches to Stop Hypertension, the Mediterranean diet, and the whole foods plant-based diet are currently being examined for their potential role in delaying CKD progression. Biological explanations for why the whole foods plant-based diet may benefit CKD patients compared to diets that include animal products are examined. Strong evidence continues to support the importance of diet meeting the daily requirement in the prevention and progression of kidney disease, and medical nutrition therapy with a registered dietitian is a critical aspect in medical intervention for CKD.

Authors+Show Affiliations

Department of Interdisciplinary Research, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA.Department of Undergraduate Health Professionals, College of Allied Health Sciences, Augusta University, Augusta, GA 30912, USA. Department of Gynecology and Obstetrics, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA. Center for Biotechnology and Genomic Medicine, Augusta University, Augusta, GA 30912, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34579153

Citation

Naber, Tania, and Sharad Purohit. "Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease." Nutrients, vol. 13, no. 9, 2021.
Naber T, Purohit S. Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease. Nutrients. 2021;13(9).
Naber, T., & Purohit, S. (2021). Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease. Nutrients, 13(9). https://doi.org/10.3390/nu13093277
Naber T, Purohit S. Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease. Nutrients. 2021 Sep 19;13(9) PubMed PMID: 34579153.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic Kidney Disease: Role of Diet for a Reduction in the Severity of the Disease. AU - Naber,Tania, AU - Purohit,Sharad, Y1 - 2021/09/19/ PY - 2021/08/10/received PY - 2021/09/13/revised PY - 2021/09/17/accepted PY - 2021/9/28/entrez PY - 2021/9/29/pubmed PY - 2021/11/19/medline KW - chronic kidney disease KW - diabetes KW - diet KW - inflammation KW - medical nutrition therapy KW - nutrition KW - plant-based foods KW - proteinuria JF - Nutrients JO - Nutrients VL - 13 IS - 9 N2 - Chronic kidney disease affects ~37 million adults in the US, and it is often undiagnosed due to a lack of apparent symptoms in early stages. Chronic kidney disease (CKD) interferes with the body's physiological and biological mechanisms, such as fluid electrolyte and pH balance, blood pressure regulation, excretion of toxins and waste, vitamin D metabolism, and hormonal regulation. Many CKD patients are at risk of hyperkalemia, hyperphosphatemia, chronic metabolic acidosis, bone deterioration, blood pressure abnormalities, and edema. These risks may be minimized, and the disease's progression may be slowed through careful monitoring of protein, phosphorus, potassium, sodium, and calcium, relieving symptoms experienced by CKD patients. In this review, the current Kidney Disease Outcomes Quality Initiative (KDOQI) recommendations are highlighted, reflecting the 2020 update, including explanations for the pathophysiology behind the recommendations. The Dietary Approaches to Stop Hypertension, the Mediterranean diet, and the whole foods plant-based diet are currently being examined for their potential role in delaying CKD progression. Biological explanations for why the whole foods plant-based diet may benefit CKD patients compared to diets that include animal products are examined. Strong evidence continues to support the importance of diet meeting the daily requirement in the prevention and progression of kidney disease, and medical nutrition therapy with a registered dietitian is a critical aspect in medical intervention for CKD. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/34579153/Chronic_Kidney_Disease:_Role_of_Diet_for_a_Reduction_in_the_Severity_of_the_Disease_ DB - PRIME DP - Unbound Medicine ER -