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Factors affecting pituitary gonadotropin function in users of oral contraceptive steroids.
Am J Obstet Gynecol. 1978 Apr 01; 130(7):817-21.AJ

Abstract

In order to determine whether certain factors influence the direct pituitary suppressive effect of contraceptive steroid, 50 subjects who had used various formulations of oral contraceptive steroids for periods of time ranging from one to nine years were stimulated with 50 microgram of gonadotropin-releasing hormone (GnRH) during the last week of oral contraceptive ingestion. The response of lutinizing hormone (LH) and follicle-stimulating hormone (FSH) was compared to the results obtained in nine control subjects with regard to: (1) age of subject. (2) type of contraceptive formulation used, and (3) length of use. Prestimulation levels of LH and FSH, respectively, were significantly decreased in 37 (74 per cent) and 42 (84 per cent) of the subjects. Following GnRH stimulation, peak responses of serum LH and FSH, respectively, were also significantly lower than those in the control subjects in 40 (80 per cent) and 45 (90 per cent of the subjects. The degree of suppression of pituitary gonadotropins, both before and after GnRH administration was significantly correlated with the type of steroid formulation used, being greatest with a combination of d-norgestrel and ethinyl estradiol. No correlation was found with length of use of oral contraceptives or age of the subjects.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

345817

Citation

Scott, J A., et al. "Factors Affecting Pituitary Gonadotropin Function in Users of Oral Contraceptive Steroids." American Journal of Obstetrics and Gynecology, vol. 130, no. 7, 1978, pp. 817-21.
Scott JA, Brenner PF, Kletzky OA, et al. Factors affecting pituitary gonadotropin function in users of oral contraceptive steroids. Am J Obstet Gynecol. 1978;130(7):817-21.
Scott, J. A., Brenner, P. F., Kletzky, O. A., & Mishell, D. R. (1978). Factors affecting pituitary gonadotropin function in users of oral contraceptive steroids. American Journal of Obstetrics and Gynecology, 130(7), 817-21.
Scott JA, et al. Factors Affecting Pituitary Gonadotropin Function in Users of Oral Contraceptive Steroids. Am J Obstet Gynecol. 1978 Apr 1;130(7):817-21. PubMed PMID: 345817.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors affecting pituitary gonadotropin function in users of oral contraceptive steroids. AU - Scott,J A, AU - Brenner,P F, AU - Kletzky,O A, AU - Mishell,D R,Jr PY - 1978/4/1/pubmed PY - 2001/3/28/medline PY - 1978/4/1/entrez KW - Age Factors KW - Biology KW - Clinical Research KW - Contraception KW - Contraceptive Agents, Estrogen--administraction and dosage KW - Contraceptive Agents, Female--administraction and dosage KW - Contraceptive Agents, Progestin--administraction and dosage KW - Contraceptive Agents--administraction and dosage KW - Contraceptive Methods--side effects KW - Demographic Factors KW - Endocrine System KW - Estradiol--analysis KW - Estrogens KW - Ethinyl Estradiol--administraction and dosage KW - Ethynodiol Diacetate--administraction and dosage KW - Family Planning KW - Follicle Stimulating Hormone--analysis KW - Gonadotropins KW - Gonadotropins, Pituitary KW - Hormones KW - Luteinizing Hormone--analysis KW - Mestranol--administraction and dosage KW - Norethindrone--administraction and dosage KW - Oral Contraceptives, Combined KW - Oral Contraceptives--side effects KW - Physiology KW - Pituitary Hormone Releasing Hormones--administraction and dosage KW - Pituitary Hormone Releasing Hormones--analysis KW - Population KW - Population Characteristics KW - Research Methodology SP - 817 EP - 21 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 130 IS - 7 N2 - In order to determine whether certain factors influence the direct pituitary suppressive effect of contraceptive steroid, 50 subjects who had used various formulations of oral contraceptive steroids for periods of time ranging from one to nine years were stimulated with 50 microgram of gonadotropin-releasing hormone (GnRH) during the last week of oral contraceptive ingestion. The response of lutinizing hormone (LH) and follicle-stimulating hormone (FSH) was compared to the results obtained in nine control subjects with regard to: (1) age of subject. (2) type of contraceptive formulation used, and (3) length of use. Prestimulation levels of LH and FSH, respectively, were significantly decreased in 37 (74 per cent) and 42 (84 per cent) of the subjects. Following GnRH stimulation, peak responses of serum LH and FSH, respectively, were also significantly lower than those in the control subjects in 40 (80 per cent) and 45 (90 per cent of the subjects. The degree of suppression of pituitary gonadotropins, both before and after GnRH administration was significantly correlated with the type of steroid formulation used, being greatest with a combination of d-norgestrel and ethinyl estradiol. No correlation was found with length of use of oral contraceptives or age of the subjects. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/345817/Factors_affecting_pituitary_gonadotropin_function_in_users_of_oral_contraceptive_steroids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9378(78)90015-7 DB - PRIME DP - Unbound Medicine ER -