TY - JOUR T1 - Asymmetric Domino Heck/Dearomatization Reaction of β-Naphthols to Construct Indole-Terpenoid Frameworks. AU - Wang,Dong-Chao, AU - Cheng,Peng-Peng, AU - Yang,Ting-Ting, AU - Wu,Pan-Pan, AU - Qu,Gui-Rong, AU - Guo,Hai-Ming, Y1 - 2021/09/28/ PY - 2021/9/29/pubmed PY - 2021/9/29/medline PY - 2021/9/28/entrez SP - 7865 EP - 7872 JF - Organic letters JO - Org Lett VL - 23 IS - 20 N2 - A palladium-catalyzed enantioselective Heck cyclization/dearomatization cascade via capturing the cyclized Heck π-allylpalladium intermediate by β-naphthols is reported, which provides a new strategy for the construction of chiral indole-terpenoid frameworks. This method affords indole-functionalized β-naphthalenone compounds bearing an all-carbon-substituted quaternary chiral center in excellent yields (up to 92%) and enantioselectivities (up to 94% ee). In addition, the utility of this method is showcased by the gram-scale syntheses and diverse transformations of the dearomatized products. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/34582193/Asymmetric_Domino_Heck/Dearomatization_Reaction_of_β_Naphthols_to_Construct_Indole_Terpenoid_Frameworks_ DB - PRIME DP - Unbound Medicine ER -