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MERS-related CoVs in hedgehogs from Hubei Province, China.
One Health. 2021 Dec; 13:100332.OH

Abstract

The emerging coronavirus diseases such as COVID-19, MERS, and SARS indicated that animal coronaviruses (CoVs) spillover to humans are a huge threat to public health. Therefore, we needed to understand the CoVs carried by various animals. Wild hedgehogs were collected from rural areas in Wuhan and Xianning cities in Hubei Province for analysis of CoVs. PCR results showed that 5 out of 51 (9.8%) hedgehogs (Erinaceus amurensis) were positive to CoVs in Hubei Province with 3 samples from Wuhan City and 2 samples from Xianning City. Phylogenetic analysis based on the partial sequence of RNA-dependent RNA polymerase showed that the CoVs from hedgehogs are classified into Merbecovirus of the genus Betacoronavirus; the hedgehog CoVs formed a phylogenetic sister cluster with human MERS-CoVs and bat MERS-related CoVs. Among the 12 most critical residues of receptor binding domain in MERS-CoV for binding human Dipeptidyl peptidase 4, 3 residuals were conserved between the hedgehog MERS-related CoV obtained in this study and the human MERS-CoV. We concluded that hedgehogs from Hubei Province carried MERS-related CoVs, indicating that hedgehogs might be important in the evolution and transmission of MERS-CoVs, and continuous surveillance of CoVs in hedgehogs was important.

Authors+Show Affiliations

State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.Double First-class Construction Office, West China Hospital, Sichuan University, Chengdu, Sichuan, China.Lab Animal Research Center, Hubei University of Chinese Medicine, Wuhan, Hubei, China.State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.Department of Neuroscience, Cell Biology, and Anatomy, 301 University Blvd, Galveston, TX 77555, United States of America.State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.State Key Laboratory of Virology, School of Health Sciences, Wuhan University, Wuhan, Hubei, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34604493

Citation

Li, Dan, et al. "MERS-related CoVs in Hedgehogs From Hubei Province, China." One Health (Amsterdam, Netherlands), vol. 13, 2021, p. 100332.
Li D, Gong XQ, Xiao X, et al. MERS-related CoVs in hedgehogs from Hubei Province, China. One Health. 2021;13:100332.
Li, D., Gong, X. Q., Xiao, X., Han, H. J., Yu, H., Li, Z. M., Yan, L. N., Gu, X. L., Duan, S. H., & Xue-jieYu, . (2021). MERS-related CoVs in hedgehogs from Hubei Province, China. One Health (Amsterdam, Netherlands), 13, 100332. https://doi.org/10.1016/j.onehlt.2021.100332
Li D, et al. MERS-related CoVs in Hedgehogs From Hubei Province, China. One Health. 2021;13:100332. PubMed PMID: 34604493.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MERS-related CoVs in hedgehogs from Hubei Province, China. AU - Li,Dan, AU - Gong,Xiao-Qing, AU - Xiao,Xiao, AU - Han,Hui-Ju, AU - Yu,Hao, AU - Li,Ze-Min, AU - Yan,Li-Na, AU - Gu,Xiao-Lan, AU - Duan,Shu-Hui, AU - Xue-jieYu,, Y1 - 2021/09/23/ PY - 2021/04/16/received PY - 2021/09/14/revised PY - 2021/09/21/accepted PY - 2021/10/4/entrez PY - 2021/10/5/pubmed PY - 2021/10/5/medline KW - Betacoronavirus KW - Coronavirus KW - Hedgehogs KW - MERS-CoVs KW - Merbecovirus SP - 100332 EP - 100332 JF - One health (Amsterdam, Netherlands) JO - One Health VL - 13 N2 - The emerging coronavirus diseases such as COVID-19, MERS, and SARS indicated that animal coronaviruses (CoVs) spillover to humans are a huge threat to public health. Therefore, we needed to understand the CoVs carried by various animals. Wild hedgehogs were collected from rural areas in Wuhan and Xianning cities in Hubei Province for analysis of CoVs. PCR results showed that 5 out of 51 (9.8%) hedgehogs (Erinaceus amurensis) were positive to CoVs in Hubei Province with 3 samples from Wuhan City and 2 samples from Xianning City. Phylogenetic analysis based on the partial sequence of RNA-dependent RNA polymerase showed that the CoVs from hedgehogs are classified into Merbecovirus of the genus Betacoronavirus; the hedgehog CoVs formed a phylogenetic sister cluster with human MERS-CoVs and bat MERS-related CoVs. Among the 12 most critical residues of receptor binding domain in MERS-CoV for binding human Dipeptidyl peptidase 4, 3 residuals were conserved between the hedgehog MERS-related CoV obtained in this study and the human MERS-CoV. We concluded that hedgehogs from Hubei Province carried MERS-related CoVs, indicating that hedgehogs might be important in the evolution and transmission of MERS-CoVs, and continuous surveillance of CoVs in hedgehogs was important. SN - 2352-7714 UR - https://www.unboundmedicine.com/medline/citation/34604493/MERS_related_CoVs_in_hedgehogs_from_Hubei_Province_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2352-7714(21)00122-1 DB - PRIME DP - Unbound Medicine ER -
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