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Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar.
N Engl J Med. 2021 12 09; 385(24):e83.NEJM

Abstract

BACKGROUND

Waning of vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 (Covid-19) is a concern. The persistence of BNT162b2 (Pfizer-BioNTech) vaccine effectiveness against infection and disease in Qatar, where the B.1.351 (or beta) and B.1.617.2 (or delta) variants have dominated incidence and polymerase-chain-reaction testing is done on a mass scale, is unclear.

METHODS

We used a matched test-negative, case-control study design to estimate vaccine effectiveness against any SARS-CoV-2 infection and against any severe, critical, or fatal case of Covid-19, from January 1 to September 5, 2021.

RESULTS

Estimated BNT162b2 effectiveness against any SARS-CoV-2 infection was negligible in the first 2 weeks after the first dose. It increased to 36.8% (95% confidence interval [CI], 33.2 to 40.2) in the third week after the first dose and reached its peak at 77.5% (95% CI, 76.4 to 78.6) in the first month after the second dose. Effectiveness declined gradually thereafter, with the decline accelerating after the fourth month to reach approximately 20% in months 5 through 7 after the second dose. Effectiveness against symptomatic infection was higher than effectiveness against asymptomatic infection but waned similarly. Variant-specific effectiveness waned in the same pattern. Effectiveness against any severe, critical, or fatal case of Covid-19 increased rapidly to 66.1% (95% CI, 56.8 to 73.5) by the third week after the first dose and reached 96% or higher in the first 2 months after the second dose; effectiveness persisted at approximately this level for 6 months.

CONCLUSIONS

BNT162b2-induced protection against SARS-CoV-2 infection appeared to wane rapidly following its peak after the second dose, but protection against hospitalization and death persisted at a robust level for 6 months after the second dose. (Funded by Weill Cornell Medicine-Qatar and others.).

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Authors+Show Affiliations

Chemaitelly H
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Tang P
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Hasan MR
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
AlMukdad S
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Yassine HM
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Benslimane FM
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Al Khatib HA
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Coyle P
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Ayoub HH
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Al Kanaani Z
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Al Kuwari E
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Jeremijenko A
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Kaleeckal AH
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Latif AN
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Shaik RM
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Abdul Rahim HF
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Nasrallah GK
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Al Kuwari MG
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Al Romaihi HE
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Butt AA
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Al-Thani MH
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Al Khal A
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Bertollini R
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).
Abu-Raddad LJ
From the Infectious Disease Epidemiology Group (H.C., S.A., L.J.A.-R.) and the World Health Organization Collaborating Center for Disease Epidemiology Analytics on HIV/AIDS, Sexually Transmitted Infections, and Viral Hepatitis (H.C., S.A., L.J.A.-R.), Weill Cornell Medicine-Qatar, Cornell University, Qatar Foundation-Education City, the Department of Pathology, Sidra Medicine (P.T., M.R.H.), the Biomedical Research Center, Member of QU Health (H.M.Y., F.M.B., H.A.A.K., P.C., G.K.N.), the Departments of Biomedical Science (H.M.Y., F.M.B., H.A.A.K., G.K.N.) and Public Health (H.F.A.R., L.J.A.-R.), College of Health Sciences, and the Mathematics Program, Department of Mathematics, Statistics, and Physics, College of Arts and Sciences (H.H.A.), Qatar University, Hamad Medical Corporation (P.C., Z.A.K., E.A.K., A.J., A.H.K., A.N.L., R.M.S., A.A.B., A.A.K.), Primary Health Care Corporation (M.G.A.K.), and the Ministry of Public Health (H.E.A.R., M.H.A.-T., R.B.) - all in Doha, Qatar; Wellcome-Wolfson Institute for Experimental Medicine, Queens University, Belfast, United Kingdom (P.C.); and the Department of Population Health Sciences, Weill Cornell Medicine, Cornell University, New York (A.A.B., L.J.A.-R.).

MeSH

2019-nCoV Vaccine mRNA-1273AdultAgedBNT162 VaccineCOVID-19COVID-19 VaccinesCase-Control StudiesFemaleHumansImmunization, SecondaryImmunogenicity, VaccineMaleMiddle AgedQatarTime FactorsVaccine EfficacyYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34614327

Citation

Chemaitelly, Hiam, et al. "Waning of BNT162b2 Vaccine Protection Against SARS-CoV-2 Infection in Qatar." The New England Journal of Medicine, vol. 385, no. 24, 2021, pp. e83.
Chemaitelly H, Tang P, Hasan MR, et al. Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar. N Engl J Med. 2021;385(24):e83.
Chemaitelly, H., Tang, P., Hasan, M. R., AlMukdad, S., Yassine, H. M., Benslimane, F. M., Al Khatib, H. A., Coyle, P., Ayoub, H. H., Al Kanaani, Z., Al Kuwari, E., Jeremijenko, A., Kaleeckal, A. H., Latif, A. N., Shaik, R. M., Abdul Rahim, H. F., Nasrallah, G. K., Al Kuwari, M. G., Al Romaihi, H. E., ... Abu-Raddad, L. J. (2021). Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar. The New England Journal of Medicine, 385(24), e83. https://doi.org/10.1056/NEJMoa2114114
Chemaitelly H, et al. Waning of BNT162b2 Vaccine Protection Against SARS-CoV-2 Infection in Qatar. N Engl J Med. 2021 12 9;385(24):e83. PubMed PMID: 34614327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Waning of BNT162b2 Vaccine Protection against SARS-CoV-2 Infection in Qatar. AU - Chemaitelly,Hiam, AU - Tang,Patrick, AU - Hasan,Mohammad R, AU - AlMukdad,Sawsan, AU - Yassine,Hadi M, AU - Benslimane,Fatiha M, AU - Al Khatib,Hebah A, AU - Coyle,Peter, AU - Ayoub,Houssein H, AU - Al Kanaani,Zaina, AU - Al Kuwari,Einas, AU - Jeremijenko,Andrew, AU - Kaleeckal,Anvar H, AU - Latif,Ali N, AU - Shaik,Riyazuddin M, AU - Abdul Rahim,Hanan F, AU - Nasrallah,Gheyath K, AU - Al Kuwari,Mohamed G, AU - Al Romaihi,Hamad E, AU - Butt,Adeel A, AU - Al-Thani,Mohamed H, AU - Al Khal,Abdullatif, AU - Bertollini,Roberto, AU - Abu-Raddad,Laith J, Y1 - 2021/10/06/ PY - 2021/10/7/pubmed PY - 2021/12/24/medline PY - 2021/10/6/entrez SP - e83 EP - e83 JF - The New England journal of medicine JO - N Engl J Med VL - 385 IS - 24 N2 - BACKGROUND: Waning of vaccine protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection or coronavirus disease 2019 (Covid-19) is a concern. The persistence of BNT162b2 (Pfizer-BioNTech) vaccine effectiveness against infection and disease in Qatar, where the B.1.351 (or beta) and B.1.617.2 (or delta) variants have dominated incidence and polymerase-chain-reaction testing is done on a mass scale, is unclear. METHODS: We used a matched test-negative, case-control study design to estimate vaccine effectiveness against any SARS-CoV-2 infection and against any severe, critical, or fatal case of Covid-19, from January 1 to September 5, 2021. RESULTS: Estimated BNT162b2 effectiveness against any SARS-CoV-2 infection was negligible in the first 2 weeks after the first dose. It increased to 36.8% (95% confidence interval [CI], 33.2 to 40.2) in the third week after the first dose and reached its peak at 77.5% (95% CI, 76.4 to 78.6) in the first month after the second dose. Effectiveness declined gradually thereafter, with the decline accelerating after the fourth month to reach approximately 20% in months 5 through 7 after the second dose. Effectiveness against symptomatic infection was higher than effectiveness against asymptomatic infection but waned similarly. Variant-specific effectiveness waned in the same pattern. Effectiveness against any severe, critical, or fatal case of Covid-19 increased rapidly to 66.1% (95% CI, 56.8 to 73.5) by the third week after the first dose and reached 96% or higher in the first 2 months after the second dose; effectiveness persisted at approximately this level for 6 months. CONCLUSIONS: BNT162b2-induced protection against SARS-CoV-2 infection appeared to wane rapidly following its peak after the second dose, but protection against hospitalization and death persisted at a robust level for 6 months after the second dose. (Funded by Weill Cornell Medicine-Qatar and others.). SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/34614327/Waning_of_BNT162b2_Vaccine_Protection_against_SARS_CoV_2_Infection_in_Qatar_ DB - PRIME DP - Unbound Medicine ER -