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A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women.
J Nutr. 2022 01 11; 152(1):5-15.JN

Abstract

BACKGROUND

Elevated concentrations of serum inflammatory cytokines, specifically TNF-α and IL-6, as well as C-reactive protein (CRP), are commonly observed after menopause.

OBJECTIVES

Because soy isoflavones may have some anti-inflammatory potential, the aim of the present systematic review and meta-analysis of randomized controlled trials (RCTs) was to explore whether soy intake affects serum markers of inflammation in postmenopausal women.

METHODS

PubMed, Web of Science, and the Cochrane Library were systematically searched up to August 2020. All RCTs that met the following criteria were included: 1) studies of the effects of soy intake on inflammatory markers; 2) any date of publication; 3) conducted on postmenopausal women; 4) with sufficient quantitative data for meta-analysis. Effect sizes were expressed as weighted mean differences (WMDs) and 95% CIs. A total of 24 RCTs assessing the effects of soy intake on serum concentrations of CRP, TNF-α, and IL-6 were included in the analysis. A random-effects model was used to determine the overall effect.

RESULTS

Soy supplementation significantly reduced CRP by 0.11 mg/L in postmenopausal women (95% CI: -0.22, -0.004 mg/L; P = 0.0414), but did not affect IL-6 or TNF-α. Significant reductions in CRP concentration occurred when natural soy products were given (WMD: -0.23 mg/L; 95% CI: -0.29, -0.17 mg/L; P < 0.001). This is equivalent to a ∼9% reduction in CRP concentration from baseline.

CONCLUSIONS

Although our meta-analysis found evidence that soy products significantly reduce CRP concentrations in postmenopausal women, the mechanisms by which soy foods and their constituents affect inflammatory biomarkers still need to be clarified.This systematic review was registered at www.crd.york.ac.uk/prospero/ as CRD42020179232.

Authors+Show Affiliations

Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poznań, Poland.Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poznań, Poland.Department of Health Management, School of Health Studies, Tokai University, Hiratsukashi, Kanagawa, Japan.Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poznań, Poland.Department of Human Nutrition and Dietetics, Poznań University of Life Sciences, Poznań, Poland.Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.Department of Innovative Food Sciences, School of Food Sciences and Nutrition, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.Institute for World Health Development, Mukogawa Women's University, Nishinomiya, Hyogo, Japan.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

34642749

Citation

Bajerska, Joanna, et al. "A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake On Inflammatory Markers in Postmenopausal Women." The Journal of Nutrition, vol. 152, no. 1, 2022, pp. 5-15.
Bajerska J, Łagowska K, Mori M, et al. A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women. J Nutr. 2022;152(1):5-15.
Bajerska, J., Łagowska, K., Mori, M., Reguła, J., Skoczek-Rubińska, A., Toda, T., Mizuno, N., & Yamori, Y. (2022). A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women. The Journal of Nutrition, 152(1), 5-15. https://doi.org/10.1093/jn/nxab325
Bajerska J, et al. A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake On Inflammatory Markers in Postmenopausal Women. J Nutr. 2022 01 11;152(1):5-15. PubMed PMID: 34642749.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Meta-Analysis of Randomized Controlled Trials of the Effects of Soy Intake on Inflammatory Markers in Postmenopausal Women. AU - Bajerska,Joanna, AU - Łagowska,Karolina, AU - Mori,Mari, AU - Reguła,Julita, AU - Skoczek-Rubińska,Aleksandra, AU - Toda,Toshiya, AU - Mizuno,Naho, AU - Yamori,Yukio, PY - 2021/04/23/received PY - 2021/05/21/revised PY - 2021/09/08/accepted PY - 2021/10/14/pubmed PY - 2022/2/22/medline PY - 2021/10/13/entrez KW - C-reactive protein KW - inflammation KW - meta-analysis KW - postmenopausal women KW - soy isoflavones SP - 5 EP - 15 JF - The Journal of nutrition JO - J Nutr VL - 152 IS - 1 N2 - BACKGROUND: Elevated concentrations of serum inflammatory cytokines, specifically TNF-α and IL-6, as well as C-reactive protein (CRP), are commonly observed after menopause. OBJECTIVES: Because soy isoflavones may have some anti-inflammatory potential, the aim of the present systematic review and meta-analysis of randomized controlled trials (RCTs) was to explore whether soy intake affects serum markers of inflammation in postmenopausal women. METHODS: PubMed, Web of Science, and the Cochrane Library were systematically searched up to August 2020. All RCTs that met the following criteria were included: 1) studies of the effects of soy intake on inflammatory markers; 2) any date of publication; 3) conducted on postmenopausal women; 4) with sufficient quantitative data for meta-analysis. Effect sizes were expressed as weighted mean differences (WMDs) and 95% CIs. A total of 24 RCTs assessing the effects of soy intake on serum concentrations of CRP, TNF-α, and IL-6 were included in the analysis. A random-effects model was used to determine the overall effect. RESULTS: Soy supplementation significantly reduced CRP by 0.11 mg/L in postmenopausal women (95% CI: -0.22, -0.004 mg/L; P = 0.0414), but did not affect IL-6 or TNF-α. Significant reductions in CRP concentration occurred when natural soy products were given (WMD: -0.23 mg/L; 95% CI: -0.29, -0.17 mg/L; P < 0.001). This is equivalent to a ∼9% reduction in CRP concentration from baseline. CONCLUSIONS: Although our meta-analysis found evidence that soy products significantly reduce CRP concentrations in postmenopausal women, the mechanisms by which soy foods and their constituents affect inflammatory biomarkers still need to be clarified.This systematic review was registered at www.crd.york.ac.uk/prospero/ as CRD42020179232. SN - 1541-6100 UR - https://www.unboundmedicine.com/medline/citation/34642749/A_Meta_Analysis_of_Randomized_Controlled_Trials_of_the_Effects_of_Soy_Intake_on_Inflammatory_Markers_in_Postmenopausal_Women_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/nxab325 DB - PRIME DP - Unbound Medicine ER -