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Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature.
Int J Mol Sci. 2021 Oct 18; 22(20)IJ

Abstract

Parkinson's disease (PD) is a slowly progressive multisystem disorder affecting dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized by a decrease of dopamine (DA) in their striatal terminals. Treatment of PD with levodopa or DA receptor agonists replaces the function of depleted DA in the striatum. Prolonged treatment with these agents often has variable therapeutic effects and leads to the development of undesirable dyskinesia. Consequently, a crucial unmet demand in the management of Parkinson's disease is the discovery of new approaches that could slow down, stop, or reverse the process of neurodegeneration. Novel potential treatments involving natural substances with neuroprotective activities are being developed. Curcumin is a polyphenolic compound isolated from the rhizomes of Curcuma longa (turmeric). It has been demonstrated to have potent anti-inflammatory, antioxidant, free radical scavenging, mitochondrial protecting, and iron-chelating effects, and is considered a promising therapeutic and nutraceutical agent for the treatment of PD. However, molecular and cellular mechanisms that mediate the pharmacological actions of curcumin remain largely unknown. Stimulation of nicotinic receptors and, more precisely, selective α7 nicotinic acetylcholine receptors (α7-nAChR), have been found to play a major modulatory role in the immune system via the "cholinergic anti-inflammatory pathway". Recently, α7-nAChR has been proposed to be a potential therapeutic approach in PD. In this review, the detailed mechanisms of the neuroprotective activities of curcumin as a potential therapeutic agent to help Parkinson's patients are being discussed and elaborated on in detail.

Authors+Show Affiliations

Department of Pharmacology, Dubai Medical College, Dubai 20170, United Arab Emirates.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34681908

Citation

Nebrisi, Eslam El. "Neuroprotective Activities of Curcumin in Parkinson's Disease: a Review of the Literature." International Journal of Molecular Sciences, vol. 22, no. 20, 2021.
Nebrisi EE. Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature. Int J Mol Sci. 2021;22(20).
Nebrisi, E. E. (2021). Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature. International Journal of Molecular Sciences, 22(20). https://doi.org/10.3390/ijms222011248
Nebrisi EE. Neuroprotective Activities of Curcumin in Parkinson's Disease: a Review of the Literature. Int J Mol Sci. 2021 Oct 18;22(20) PubMed PMID: 34681908.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective Activities of Curcumin in Parkinson's Disease: A Review of the Literature. A1 - Nebrisi,Eslam El, Y1 - 2021/10/18/ PY - 2021/08/14/received PY - 2021/08/30/revised PY - 2021/09/04/accepted PY - 2021/10/23/entrez PY - 2021/10/24/pubmed PY - 2021/12/16/medline KW - Parkinson’s disease KW - anti-inflammatory KW - antioxidant KW - curcumin KW - neuroprotection KW - α7-nAChR JF - International journal of molecular sciences JO - Int J Mol Sci VL - 22 IS - 20 N2 - Parkinson's disease (PD) is a slowly progressive multisystem disorder affecting dopaminergic neurons of the substantia nigra pars compacta (SNpc), which is characterized by a decrease of dopamine (DA) in their striatal terminals. Treatment of PD with levodopa or DA receptor agonists replaces the function of depleted DA in the striatum. Prolonged treatment with these agents often has variable therapeutic effects and leads to the development of undesirable dyskinesia. Consequently, a crucial unmet demand in the management of Parkinson's disease is the discovery of new approaches that could slow down, stop, or reverse the process of neurodegeneration. Novel potential treatments involving natural substances with neuroprotective activities are being developed. Curcumin is a polyphenolic compound isolated from the rhizomes of Curcuma longa (turmeric). It has been demonstrated to have potent anti-inflammatory, antioxidant, free radical scavenging, mitochondrial protecting, and iron-chelating effects, and is considered a promising therapeutic and nutraceutical agent for the treatment of PD. However, molecular and cellular mechanisms that mediate the pharmacological actions of curcumin remain largely unknown. Stimulation of nicotinic receptors and, more precisely, selective α7 nicotinic acetylcholine receptors (α7-nAChR), have been found to play a major modulatory role in the immune system via the "cholinergic anti-inflammatory pathway". Recently, α7-nAChR has been proposed to be a potential therapeutic approach in PD. In this review, the detailed mechanisms of the neuroprotective activities of curcumin as a potential therapeutic agent to help Parkinson's patients are being discussed and elaborated on in detail. SN - 1422-0067 UR - https://www.unboundmedicine.com/medline/citation/34681908/Neuroprotective_Activities_of_Curcumin_in_Parkinson's_Disease:_A_Review_of_the_Literature_ DB - PRIME DP - Unbound Medicine ER -