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Genetic linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers.
Neurology. 1987 Feb; 37(2):325-9.Neur

Abstract

Hereditary motor and sensory neuropathy-Ib (HMSN-Ib) is a common autosomal dominant disorder linked to the Duffy blood group locus on human chromosome 1. The gene for antithrombin III (AT3) is also located on the long arm of chromosome 1. Using a DNA restriction fragment length polymorphism for AT3, we have investigated the genetic linkage relationship of all three markers (HMSN-Ib, Duffy, and AT3) in two affected families. Neither HMSN-Ib nor Duffy was tightly linked to AT3. The loci for both HMSN-Ib and Duffy must be close to the centromere on chromosome 1, but precise localization and gene order require study of additional markers and more families.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3468376

Citation

Chance, P F., et al. "Genetic Linkage Relationships of Charcot-Marie-Tooth Disease (HMSN-Ib) to Chromosome 1 Markers." Neurology, vol. 37, no. 2, 1987, pp. 325-9.
Chance PF, Murray JC, Bird TD, et al. Genetic linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers. Neurology. 1987;37(2):325-9.
Chance, P. F., Murray, J. C., Bird, T. D., & Kochin, R. S. (1987). Genetic linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers. Neurology, 37(2), 325-9.
Chance PF, et al. Genetic Linkage Relationships of Charcot-Marie-Tooth Disease (HMSN-Ib) to Chromosome 1 Markers. Neurology. 1987;37(2):325-9. PubMed PMID: 3468376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genetic linkage relationships of Charcot-Marie-Tooth disease (HMSN-Ib) to chromosome 1 markers. AU - Chance,P F, AU - Murray,J C, AU - Bird,T D, AU - Kochin,R S, PY - 1987/2/1/pubmed PY - 1987/2/1/medline PY - 1987/2/1/entrez SP - 325 EP - 9 JF - Neurology JO - Neurology VL - 37 IS - 2 N2 - Hereditary motor and sensory neuropathy-Ib (HMSN-Ib) is a common autosomal dominant disorder linked to the Duffy blood group locus on human chromosome 1. The gene for antithrombin III (AT3) is also located on the long arm of chromosome 1. Using a DNA restriction fragment length polymorphism for AT3, we have investigated the genetic linkage relationship of all three markers (HMSN-Ib, Duffy, and AT3) in two affected families. Neither HMSN-Ib nor Duffy was tightly linked to AT3. The loci for both HMSN-Ib and Duffy must be close to the centromere on chromosome 1, but precise localization and gene order require study of additional markers and more families. SN - 0028-3878 UR - https://www.unboundmedicine.com/medline/citation/3468376/Genetic_linkage_relationships_of_Charcot_Marie_Tooth_disease__HMSN_Ib__to_chromosome_1_markers_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=3468376.ui DB - PRIME DP - Unbound Medicine ER -