Abstract
BACKGROUND
Coronary artery ectasia (CAE) is a rare cardiovascular disorder with unknown mechanisms and related risk factors. The roles played by homocysteine in induction of cardiovascular diseases (CVDs) have also been documented previously. This project was designed to assess the relationship between opium and CAE and coronary artery disease (CAD).
METHODS
This cross-sectional study was performed on 46 patients with CAE, 30 patients with CAD, and 42 cases without CAE and CAD (controls). Demographic data and information regarding opium consuming and also smoking were collected using a standard checklist. Serum levels of homocysteine, creatinine (Cr), urea, fasting blood glucose (FBG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and cholesterol were determined.
FINDINGS
Statistical analysis revealed that opium consumers were significantly higher in patients with CAD and CAE when compared to healthy controls. Opium increased serum levels of Cr in the normal controls, and decreased HDL in the patients with CAD. Homocysteine serum levels were not significantly different between the groups.
CONCLUSION
The results of study showed that opium addiction was associated with increased risk of CAE and CAD, independent of homocysteine serum levels.
TY - JOUR
T1 - Association of Opium Addiction with Coronary Artery Ectasia and Coronary Artery Disease.
AU - Bahrami,Naemeh,
AU - Asadikaram,Gholamreza,
AU - Masoumi,Mohammad,
PY - 2020/12/03/received
PY - 2021/02/07/accepted
PY - 2021/10/27/entrez
PY - 2021/10/28/pubmed
PY - 2021/10/28/medline
KW - Coronary artery disease
KW - Homocysteine
KW - Opium
SP - 77
EP - 84
JF - Addiction & health
JO - Addict Health
VL - 13
IS - 2
N2 - BACKGROUND: Coronary artery ectasia (CAE) is a rare cardiovascular disorder with unknown mechanisms and related risk factors. The roles played by homocysteine in induction of cardiovascular diseases (CVDs) have also been documented previously. This project was designed to assess the relationship between opium and CAE and coronary artery disease (CAD). METHODS: This cross-sectional study was performed on 46 patients with CAE, 30 patients with CAD, and 42 cases without CAE and CAD (controls). Demographic data and information regarding opium consuming and also smoking were collected using a standard checklist. Serum levels of homocysteine, creatinine (Cr), urea, fasting blood glucose (FBG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), triglyceride (TG), and cholesterol were determined. FINDINGS: Statistical analysis revealed that opium consumers were significantly higher in patients with CAD and CAE when compared to healthy controls. Opium increased serum levels of Cr in the normal controls, and decreased HDL in the patients with CAD. Homocysteine serum levels were not significantly different between the groups. CONCLUSION: The results of study showed that opium addiction was associated with increased risk of CAE and CAD, independent of homocysteine serum levels.
SN - 2008-4633
UR - https://www.unboundmedicine.com/medline/citation/34703528/Association_of_Opium_Addiction_with_Coronary_Artery_Ectasia_and_Coronary_Artery_Disease_
DB - PRIME
DP - Unbound Medicine
ER -
