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Palladium-Catalyzed Cascade Allylative Dicarbofunctionalization of Aryl Phenol-Tethered Alkynes with Allyl Iodides: Synthesis of Skipped Dienes.
Org Lett. 2021 11 05; 23(21):8333-8337.OL

Abstract

A palladium-catalyzed cascade allylative dicarbofunctionalization of aryl phenol-tethered alkynes with allyl iodides is described. A series of polysubstituted spirocyclo-containing skipped dienes with an all-carbon tetrasubstituted alkene unit are synthesized through this convenient process. The cascade reaction proceeds selectively through dearomative C-allylation instead of O-allylation of aryl phenols.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Liu A
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Chi D
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.
Chen S
Inner Mongolia Key Laboratory of Fine Organic Synthesis, Department of Chemistry and Chemical Engineering, Inner Mongolia University, Hohhot 010021, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34704443

Citation

Liu, Anjia, et al. "Palladium-Catalyzed Cascade Allylative Dicarbofunctionalization of Aryl Phenol-Tethered Alkynes With Allyl Iodides: Synthesis of Skipped Dienes." Organic Letters, vol. 23, no. 21, 2021, pp. 8333-8337.
Liu A, Chi D, Chen S. Palladium-Catalyzed Cascade Allylative Dicarbofunctionalization of Aryl Phenol-Tethered Alkynes with Allyl Iodides: Synthesis of Skipped Dienes. Org Lett. 2021;23(21):8333-8337.
Liu, A., Chi, D., & Chen, S. (2021). Palladium-Catalyzed Cascade Allylative Dicarbofunctionalization of Aryl Phenol-Tethered Alkynes with Allyl Iodides: Synthesis of Skipped Dienes. Organic Letters, 23(21), 8333-8337. https://doi.org/10.1021/acs.orglett.1c03073
Liu A, Chi D, Chen S. Palladium-Catalyzed Cascade Allylative Dicarbofunctionalization of Aryl Phenol-Tethered Alkynes With Allyl Iodides: Synthesis of Skipped Dienes. Org Lett. 2021 11 5;23(21):8333-8337. PubMed PMID: 34704443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Palladium-Catalyzed Cascade Allylative Dicarbofunctionalization of Aryl Phenol-Tethered Alkynes with Allyl Iodides: Synthesis of Skipped Dienes. AU - Liu,Anjia, AU - Chi,Dongmei, AU - Chen,Shufeng, Y1 - 2021/10/27/ PY - 2021/10/28/pubmed PY - 2021/10/28/medline PY - 2021/10/27/entrez SP - 8333 EP - 8337 JF - Organic letters JO - Org Lett VL - 23 IS - 21 N2 - A palladium-catalyzed cascade allylative dicarbofunctionalization of aryl phenol-tethered alkynes with allyl iodides is described. A series of polysubstituted spirocyclo-containing skipped dienes with an all-carbon tetrasubstituted alkene unit are synthesized through this convenient process. The cascade reaction proceeds selectively through dearomative C-allylation instead of O-allylation of aryl phenols. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/34704443/Palladium_Catalyzed_Cascade_Allylative_Dicarbofunctionalization_of_Aryl_Phenol_Tethered_Alkynes_with_Allyl_Iodides:_Synthesis_of_Skipped_Dienes_ DB - PRIME DP - Unbound Medicine ER -
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