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Role of thromboxane (Tx) A2 in guinea pig Forssman shock and the effect of OKY-046, Tx A2 synthetase inhibitor.
Prostaglandins Leukot Med 1987; 26(2):133-41PL

Abstract

To study the role of thromboxane (Tx) A2 in Forssman systemic shock (FSS) in guinea pig, the effect of (E)-3-[p-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride (OKY-046), a specific Tx A2 synthetase inhibitor, was studied. OKY-046 administered intravenously clearly prolonged survival time and protected against fatal shock. In shocked animals, definite decreases in serum complement hemolytic activity (CH50), leucocyte counts and platelet counts and an increase in lactate dehydrogenase (LDH) activity were observed. In addition, a significant increase of Tx B2 and incoagulability of blood were observed after shock. Whereas OKY-046 had no effect on the decreases in CH50, platelet counts and leucocyte counts, it inhibited the increase of Tx B2 and increased the amount of 6-keto PG F1 alpha. When Forssman antibody (half a lethal dose) was injected, a diphasic increase in airway resistance was observed. OKY-046 inhibited this diphasic increase in airway resistance. These data suggest a pathophysiological role for Tx A2 in FSS. OKY-046 inhibited the Forssman antibody induced respiratory disorders probably due to the inhibition of Tx A2 synthesis after shock.

Authors

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Pub Type(s)

Journal Article

Language

eng

PubMed ID

3470814

Citation

Nagai, H, et al. "Role of Thromboxane (Tx) A2 in Guinea Pig Forssman Shock and the Effect of OKY-046, Tx A2 Synthetase Inhibitor." Prostaglandins, Leukotrienes, and Medicine, vol. 26, no. 2, 1987, pp. 133-41.
Nagai H, Yakuo I, Inagaki N, et al. Role of thromboxane (Tx) A2 in guinea pig Forssman shock and the effect of OKY-046, Tx A2 synthetase inhibitor. Prostaglandins Leukot Med. 1987;26(2):133-41.
Nagai, H., Yakuo, I., Inagaki, N., Koda, A., Hamano, S., Ujiie, A., & Nakazawa, M. (1987). Role of thromboxane (Tx) A2 in guinea pig Forssman shock and the effect of OKY-046, Tx A2 synthetase inhibitor. Prostaglandins, Leukotrienes, and Medicine, 26(2), pp. 133-41.
Nagai H, et al. Role of Thromboxane (Tx) A2 in Guinea Pig Forssman Shock and the Effect of OKY-046, Tx A2 Synthetase Inhibitor. Prostaglandins Leukot Med. 1987;26(2):133-41. PubMed PMID: 3470814.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Role of thromboxane (Tx) A2 in guinea pig Forssman shock and the effect of OKY-046, Tx A2 synthetase inhibitor. AU - Nagai,H, AU - Yakuo,I, AU - Inagaki,N, AU - Koda,A, AU - Hamano,S, AU - Ujiie,A, AU - Nakazawa,M, PY - 1987/2/1/pubmed PY - 1987/2/1/medline PY - 1987/2/1/entrez SP - 133 EP - 41 JF - Prostaglandins, leukotrienes, and medicine JO - Prostaglandins Leukot Med VL - 26 IS - 2 N2 - To study the role of thromboxane (Tx) A2 in Forssman systemic shock (FSS) in guinea pig, the effect of (E)-3-[p-(1H-Imidazol-1-ylmethyl)phenyl]-2-propenoic acid hydrochloride (OKY-046), a specific Tx A2 synthetase inhibitor, was studied. OKY-046 administered intravenously clearly prolonged survival time and protected against fatal shock. In shocked animals, definite decreases in serum complement hemolytic activity (CH50), leucocyte counts and platelet counts and an increase in lactate dehydrogenase (LDH) activity were observed. In addition, a significant increase of Tx B2 and incoagulability of blood were observed after shock. Whereas OKY-046 had no effect on the decreases in CH50, platelet counts and leucocyte counts, it inhibited the increase of Tx B2 and increased the amount of 6-keto PG F1 alpha. When Forssman antibody (half a lethal dose) was injected, a diphasic increase in airway resistance was observed. OKY-046 inhibited this diphasic increase in airway resistance. These data suggest a pathophysiological role for Tx A2 in FSS. OKY-046 inhibited the Forssman antibody induced respiratory disorders probably due to the inhibition of Tx A2 synthesis after shock. SN - 0262-1746 UR - https://www.unboundmedicine.com/medline/citation/3470814/Role_of_thromboxane__Tx__A2_in_guinea_pig_Forssman_shock_and_the_effect_of_OKY_046_Tx_A2_synthetase_inhibitor_ L2 - https://medlineplus.gov/anaphylaxis.html DB - PRIME DP - Unbound Medicine ER -