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Potential roles of mesenchymal stem cells and their exosomes in the treatment of COVID-19.
Front Biosci (Landmark Ed). 2021 10 30; 26(10):948-961.FB

Abstract

Background: Corona Virus Disease 2019 (COVID-19) is an acute respiratory infectious disease caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2). The primary pathogenesis is over-activation of the immune system. SARS-CoV-2 continues to mutate and spread rapidly and no effective treatment options are yet available. Mesenchymal stem cells (MSCs) are known to induce anti-inflammatory macrophages, regulatory T cells and dendritic cells. There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. Objective: To summarize the pathogenic mechanism of SARS-CoV-2, and systematically formulated the immunomodulation of COVID-19 by MSCs and their exosomes, as well as research progress. Method: Searching PubMed, clinicaltrials.gov and Chictr.cn for eligible studies to be published or registered by May 2021. Main keywords and search strategies were as follows: ((Mesenchymal stem cells) OR (MSCs)) AND (COVID-19). Results: MSCs regulate the immune system to prevent cytokine release syndrome (CRS) and to promote endogenous repair by releasing various paracrine factors and exosomes. Conclusions: MSC therapy is thus a promising candidate for COVID-19.

Authors+Show Affiliations

Department of Pulmonary and Critical Care Medicine, Xiangya Hospital of Central South University, 410008 Changsha, Hunan, China.Department of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, 410008 Changsha, Hunan, China.Department of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, 410008 Changsha, Hunan, China.Department of Pulmonary and Critical Care Medicine, The Third Xiangya Hospital of Central South University, 410008 Changsha, Hunan, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

34719217

Citation

Cheng, Xiaoyun, et al. "Potential Roles of Mesenchymal Stem Cells and Their Exosomes in the Treatment of COVID-19." Frontiers in Bioscience (Landmark Edition), vol. 26, no. 10, 2021, pp. 948-961.
Cheng X, Jiang M, Long L, et al. Potential roles of mesenchymal stem cells and their exosomes in the treatment of COVID-19. Front Biosci (Landmark Ed). 2021;26(10):948-961.
Cheng, X., Jiang, M., Long, L., & Meng, J. (2021). Potential roles of mesenchymal stem cells and their exosomes in the treatment of COVID-19. Frontiers in Bioscience (Landmark Edition), 26(10), 948-961. https://doi.org/10.52586/4999
Cheng X, et al. Potential Roles of Mesenchymal Stem Cells and Their Exosomes in the Treatment of COVID-19. Front Biosci (Landmark Ed). 2021 10 30;26(10):948-961. PubMed PMID: 34719217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential roles of mesenchymal stem cells and their exosomes in the treatment of COVID-19. AU - Cheng,Xiaoyun, AU - Jiang,Mao, AU - Long,Lingzhi, AU - Meng,Jie, PY - 2021/06/06/received PY - 2021/08/17/revised PY - 2021/09/01/accepted PY - 2021/11/1/entrez PY - 2021/11/2/pubmed PY - 2021/11/16/medline KW - COVID-19 KW - Exosome KW - Immunoregulation KW - Mesenchymal stem cell KW - SARS-CoV-2 SP - 948 EP - 961 JF - Frontiers in bioscience (Landmark edition) JO - Front Biosci (Landmark Ed) VL - 26 IS - 10 N2 - Background: Corona Virus Disease 2019 (COVID-19) is an acute respiratory infectious disease caused by severe respiratory syndrome coronavirus 2 (SARS-CoV-2). The primary pathogenesis is over-activation of the immune system. SARS-CoV-2 continues to mutate and spread rapidly and no effective treatment options are yet available. Mesenchymal stem cells (MSCs) are known to induce anti-inflammatory macrophages, regulatory T cells and dendritic cells. There are a rapidly increasing number of clinical investigations of cell-based therapy approaches for COVID-19. Objective: To summarize the pathogenic mechanism of SARS-CoV-2, and systematically formulated the immunomodulation of COVID-19 by MSCs and their exosomes, as well as research progress. Method: Searching PubMed, clinicaltrials.gov and Chictr.cn for eligible studies to be published or registered by May 2021. Main keywords and search strategies were as follows: ((Mesenchymal stem cells) OR (MSCs)) AND (COVID-19). Results: MSCs regulate the immune system to prevent cytokine release syndrome (CRS) and to promote endogenous repair by releasing various paracrine factors and exosomes. Conclusions: MSC therapy is thus a promising candidate for COVID-19. SN - 2768-6698 UR - https://www.unboundmedicine.com/medline/citation/34719217/Potential_roles_of_mesenchymal_stem_cells_and_their_exosomes_in_the_treatment_of_COVID_19_ L2 - https://www.fbscience.com/Landmark/articles/10.52586/4999 DB - PRIME DP - Unbound Medicine ER -