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Lobar bleeding with ventricular rupture shortly after first dosage of an mRNA-based SARS-CoV-2 vaccine.
Brain Hemorrhages. 2021 Oct 28 [Online ahead of print]BH

Abstract

Vaccination against SARS-CoV-2 is beneficial but may be rarely accompanied by side effects. We report a 67yo female who developed visual impairment, dysarthria, confusion, and fatigue a few hours after a first dosage with an mRNA-based SARS-CoV-2 vaccine (Pfizer). Her previous history listed diabetes, arterial hypertension, arterial occlusive disease, a single renal cyst on the left side, smoking, and ischemic stroke 20y earlier. Stroke was complicated by normal pressure hydrocephalus requiring placement of a ventriculo-atrial (VA)-shunt. Cerebral imaging revealed a right-sided intracerebral bleeding with ventricular rupture and correct placement of the VA-shunt. Neurosurgeons decided against surgical treatment. The further course was dominated by prolonged confusion, visual impairment, and disorientation but ultimately only minor deficits. In conclusion, a single patient experienced intracerebral bleeding with ventricular rupture shortly after application of the first jab of an mRNA-based SARS-CoV-2 vaccine. Whether bleeding was causally related to the vaccination or occurred coincidentally, remains speculative.

Authors+Show Affiliations

Klinik Landstrasse, Messerli Institute, Vienna, Austria.

Pub Type(s)

Case Reports

Language

eng

PubMed ID

34729467

Citation

Finsterer, Josef. "Lobar Bleeding With Ventricular Rupture Shortly After First Dosage of an mRNA-based SARS-CoV-2 Vaccine." Brain Hemorrhages, 2021.
Finsterer J. Lobar bleeding with ventricular rupture shortly after first dosage of an mRNA-based SARS-CoV-2 vaccine. Brain Hemorrhages. 2021.
Finsterer, J. (2021). Lobar bleeding with ventricular rupture shortly after first dosage of an mRNA-based SARS-CoV-2 vaccine. Brain Hemorrhages. https://doi.org/10.1016/j.hest.2021.10.001
Finsterer J. Lobar Bleeding With Ventricular Rupture Shortly After First Dosage of an mRNA-based SARS-CoV-2 Vaccine. Brain Hemorrhages. 2021 Oct 28; PubMed PMID: 34729467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lobar bleeding with ventricular rupture shortly after first dosage of an mRNA-based SARS-CoV-2 vaccine. A1 - Finsterer,Josef, Y1 - 2021/10/28/ PY - 2021/09/28/received PY - 2021/10/20/revised PY - 2021/10/22/accepted PY - 2021/11/3/entrez PY - 2021/11/4/pubmed PY - 2021/11/4/medline KW - COVID-19 KW - SARS-CoV-2 KW - adverse reaction KW - intracerebral bleeding KW - side effect KW - vaccination JF - Brain hemorrhages JO - Brain Hemorrhages N2 - Vaccination against SARS-CoV-2 is beneficial but may be rarely accompanied by side effects. We report a 67yo female who developed visual impairment, dysarthria, confusion, and fatigue a few hours after a first dosage with an mRNA-based SARS-CoV-2 vaccine (Pfizer). Her previous history listed diabetes, arterial hypertension, arterial occlusive disease, a single renal cyst on the left side, smoking, and ischemic stroke 20y earlier. Stroke was complicated by normal pressure hydrocephalus requiring placement of a ventriculo-atrial (VA)-shunt. Cerebral imaging revealed a right-sided intracerebral bleeding with ventricular rupture and correct placement of the VA-shunt. Neurosurgeons decided against surgical treatment. The further course was dominated by prolonged confusion, visual impairment, and disorientation but ultimately only minor deficits. In conclusion, a single patient experienced intracerebral bleeding with ventricular rupture shortly after application of the first jab of an mRNA-based SARS-CoV-2 vaccine. Whether bleeding was causally related to the vaccination or occurred coincidentally, remains speculative. SN - 2589-238X UR - https://www.unboundmedicine.com/medline/citation/34729467/Lobar_bleeding_with_ventricular_rupture_shortly_after_first_dosage_of_an_mRNA_based_SARS_CoV_2_vaccine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2589-238X(21)00054-1 DB - PRIME DP - Unbound Medicine ER -
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