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Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality.
Nat Commun. 2021 11 04; 12(1):6388.NC

Abstract

The relationship between dietary factors and liver disease remains poorly understood. This study evaluated the associations of whole grain and dietary fiber intake with liver cancer risk and chronic liver disease mortality. The National Institutes of Health-American Association of Retired Persons Diet and Health Study cohort recruited 485, 717 retired U.S. participants in 1995-1996. Follow-up through 2011 identified 940 incident liver cancer cases and 993 deaths from chronic liver disease. Compared with the lowest, the highest quintile of whole grain intake was associated with lower liver cancer risk (Hazard ratio [HR]Q5 vs. Q1 = 0.78, 95% confidence interval [CI]: 0.63-0.96) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.44, 95% CI: 0.35-0.55) in multivariable Cox models. Dietary fiber was also associated with lower liver cancer risk (HRQ5 vs. Q1 = 0.69, 95% CI: 0.53-0.90) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.37, 95% CI: 0.29-0.48). Fiber from vegetables, beans and grains showed potential protective effect. Here, we show that higher intake of whole grain and dietary fiber are associated with lower risk of liver cancer and liver disease mortality.

Authors+Show Affiliations

Department of Nutrition, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. Department of Epidemiology, School of Public Health, Fudan University, Shanghai, P.R. China.Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Nutrition, School of Public Health, Anhui Medical University, Hefei, Anhui, P.R. China.Slone Epidemiology Center, Boston University, Boston, MA, USA.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.Department of Epidemiology, School of Public Health, Fudan University, Shanghai, P.R. China.Department of Epidemiology, School of Public Health, Fudan University, Shanghai, P.R. China.Behavioral and Epidemiology Research Group, American Cancer Society, Atlanta, GA, USA.Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA. Jonsson Comprehensive Cancer Center, UCLA, Los Angeles, CA, USA.Department of Nutrition, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. Department of Epidemiology, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA.Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.Department of Nutrition, T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. xuehong.zhang@channing.harvard.edu. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. xuehong.zhang@channing.harvard.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34737258

Citation

Liu, Xing, et al. "Higher Intake of Whole Grains and Dietary Fiber Are Associated With Lower Risk of Liver Cancer and Chronic Liver Disease Mortality." Nature Communications, vol. 12, no. 1, 2021, p. 6388.
Liu X, Yang W, Petrick JL, et al. Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality. Nat Commun. 2021;12(1):6388.
Liu, X., Yang, W., Petrick, J. L., Liao, L. M., Wang, W., He, N., Campbell, P. T., Zhang, Z. F., Giovannucci, E., McGlynn, K. A., & Zhang, X. (2021). Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality. Nature Communications, 12(1), 6388. https://doi.org/10.1038/s41467-021-26448-9
Liu X, et al. Higher Intake of Whole Grains and Dietary Fiber Are Associated With Lower Risk of Liver Cancer and Chronic Liver Disease Mortality. Nat Commun. 2021 11 4;12(1):6388. PubMed PMID: 34737258.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher intake of whole grains and dietary fiber are associated with lower risk of liver cancer and chronic liver disease mortality. AU - Liu,Xing, AU - Yang,Wanshui, AU - Petrick,Jessica L, AU - Liao,Linda M, AU - Wang,Weibing, AU - He,Na, AU - Campbell,Peter T, AU - Zhang,Zuo-Feng, AU - Giovannucci,Edward, AU - McGlynn,Katherine A, AU - Zhang,Xuehong, Y1 - 2021/11/04/ PY - 2021/01/22/received PY - 2021/09/27/accepted PY - 2021/11/5/entrez PY - 2021/11/6/pubmed PY - 2021/12/28/medline SP - 6388 EP - 6388 JF - Nature communications JO - Nat Commun VL - 12 IS - 1 N2 - The relationship between dietary factors and liver disease remains poorly understood. This study evaluated the associations of whole grain and dietary fiber intake with liver cancer risk and chronic liver disease mortality. The National Institutes of Health-American Association of Retired Persons Diet and Health Study cohort recruited 485, 717 retired U.S. participants in 1995-1996. Follow-up through 2011 identified 940 incident liver cancer cases and 993 deaths from chronic liver disease. Compared with the lowest, the highest quintile of whole grain intake was associated with lower liver cancer risk (Hazard ratio [HR]Q5 vs. Q1 = 0.78, 95% confidence interval [CI]: 0.63-0.96) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.44, 95% CI: 0.35-0.55) in multivariable Cox models. Dietary fiber was also associated with lower liver cancer risk (HRQ5 vs. Q1 = 0.69, 95% CI: 0.53-0.90) and chronic liver disease mortality (HRQ5 vs. Q1 = 0.37, 95% CI: 0.29-0.48). Fiber from vegetables, beans and grains showed potential protective effect. Here, we show that higher intake of whole grain and dietary fiber are associated with lower risk of liver cancer and liver disease mortality. SN - 2041-1723 UR - https://www.unboundmedicine.com/medline/citation/34737258/Higher_intake_of_whole_grains_and_dietary_fiber_are_associated_with_lower_risk_of_liver_cancer_and_chronic_liver_disease_mortality_ L2 - https://doi.org/10.1038/s41467-021-26448-9 DB - PRIME DP - Unbound Medicine ER -