Tags

Type your tag names separated by a space and hit enter

Childhood leukemia and parents' occupational and home exposures.
J Natl Cancer Inst. 1987 Jul; 79(1):39-46.JNCI

Abstract

A case-control study of children of ages 10 years and under in Los Angeles County was conducted to investigate the causes of leukemia. The mothers and fathers of acute leukemia cases and their individually matched controls were interviewed regarding specific occupational and home exposures as well as other potential risk factors associated with leukemia. Analysis of the information from the 123 matched pairs showed an increased risk of leukemia for children whose fathers had occupational exposure after the birth of the child to chlorinated solvents [odds ratio (OR) = 3.5, P = .01], spray paint (OR = 2.0, P = .02), dyes or pigments (OR = 4.5, P = .03), methyl ethyl ketone (CAS: 78-93-3; OR = 3.0, P = .05), and cutting oil (OR = 1.7, P = .05) or whose fathers were exposed during the mother's pregnancy with the child to spray paint (OR = 2.2, P = .03). For all of these, the risk associated with frequent use was greater than for infrequent use. There was an increased risk of leukemia for the child if the father worked in industries manufacturing transportation equipment (mostly aircraft) (OR = 2.5, P = .03) or machinery (OR = 3.0, P = .02). An increased risk was found for children whose parents used pesticides in the home (OR = 3.8, P = .004) or garden (OR = 6.5, P = .007) or who burned incense in the home (OR = 2.7, P = .007). The risk was greater for frequent use. Risk of leukemia was related to mothers' employment in personal service industries (OR = 2.7, P = .04) but not to specified occupational exposures. Risk related to fathers' exposure to chlorinated solvents, employment in the transportation equipment-manufacturing industry, and parents' exposure to household or garden pesticides and incense remains statistically significant after adjusting for the other significant findings.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

3474448

Citation

Lowengart, R A., et al. "Childhood Leukemia and Parents' Occupational and Home Exposures." Journal of the National Cancer Institute, vol. 79, no. 1, 1987, pp. 39-46.
Lowengart RA, Peters JM, Cicioni C, et al. Childhood leukemia and parents' occupational and home exposures. J Natl Cancer Inst. 1987;79(1):39-46.
Lowengart, R. A., Peters, J. M., Cicioni, C., Buckley, J., Bernstein, L., Preston-Martin, S., & Rappaport, E. (1987). Childhood leukemia and parents' occupational and home exposures. Journal of the National Cancer Institute, 79(1), 39-46.
Lowengart RA, et al. Childhood Leukemia and Parents' Occupational and Home Exposures. J Natl Cancer Inst. 1987;79(1):39-46. PubMed PMID: 3474448.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Childhood leukemia and parents' occupational and home exposures. AU - Lowengart,R A, AU - Peters,J M, AU - Cicioni,C, AU - Buckley,J, AU - Bernstein,L, AU - Preston-Martin,S, AU - Rappaport,E, PY - 1987/7/1/pubmed PY - 1987/7/1/medline PY - 1987/7/1/entrez SP - 39 EP - 46 JF - Journal of the National Cancer Institute JO - J Natl Cancer Inst VL - 79 IS - 1 N2 - A case-control study of children of ages 10 years and under in Los Angeles County was conducted to investigate the causes of leukemia. The mothers and fathers of acute leukemia cases and their individually matched controls were interviewed regarding specific occupational and home exposures as well as other potential risk factors associated with leukemia. Analysis of the information from the 123 matched pairs showed an increased risk of leukemia for children whose fathers had occupational exposure after the birth of the child to chlorinated solvents [odds ratio (OR) = 3.5, P = .01], spray paint (OR = 2.0, P = .02), dyes or pigments (OR = 4.5, P = .03), methyl ethyl ketone (CAS: 78-93-3; OR = 3.0, P = .05), and cutting oil (OR = 1.7, P = .05) or whose fathers were exposed during the mother's pregnancy with the child to spray paint (OR = 2.2, P = .03). For all of these, the risk associated with frequent use was greater than for infrequent use. There was an increased risk of leukemia for the child if the father worked in industries manufacturing transportation equipment (mostly aircraft) (OR = 2.5, P = .03) or machinery (OR = 3.0, P = .02). An increased risk was found for children whose parents used pesticides in the home (OR = 3.8, P = .004) or garden (OR = 6.5, P = .007) or who burned incense in the home (OR = 2.7, P = .007). The risk was greater for frequent use. Risk of leukemia was related to mothers' employment in personal service industries (OR = 2.7, P = .04) but not to specified occupational exposures. Risk related to fathers' exposure to chlorinated solvents, employment in the transportation equipment-manufacturing industry, and parents' exposure to household or garden pesticides and incense remains statistically significant after adjusting for the other significant findings. SN - 0027-8874 UR - https://www.unboundmedicine.com/medline/citation/3474448/Childhood_leukemia_and_parents'_occupational_and_home_exposures_ L2 - https://medlineplus.gov/leukemia.html DB - PRIME DP - Unbound Medicine ER -