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Adherence to Mediterranean diet and its associations with circulating cytokines, musculoskeletal health and incident falls in community-dwelling older men: The Concord Health and Ageing in Men Project.
Clin Nutr. 2021 12; 40(12):5753-5763.CN

Abstract

BACKGROUND & AIMS

Mediterranean dietary patterns may exert favourable effects on various health conditions. This study aimed to determine associations of adherence to Mediterranean diet as well as its components, with circulating cytokine levels, musculoskeletal health and incident falls in community-dwelling older men.

METHODS

Seven hundred ninety-four (794) community-dwelling men with mean age 81.1 ± 4.5 years, who participated in the five-year follow-up of the Concord Health and Ageing in Men Project (CHAMP) were included in the cross-sectional analysis, and 616 attended follow-up three years later. Adherence to Mediterranean diet was assessed using MEDI-LITE (literature-derived Mediterranean diet) score which was obtained using a validated diet history questionnaire. Twenty-four evaluable circulating cytokines were analyzed using Bio-Plex Pro Human Cytokine 27-plex Assay kit. Appendicular lean mass (ALM) and bone mineral density (BMD) were measured using dual-energy x-ray absorptiometry (DXA). Three-year changes in gait speed and hand grip strength were assessed by walking a 6-m course and using a dynamometer respectively and analyzed using linear mixed-effects models. Incident falls over three years were determined through telephone interviews every four months. Multivariable linear regression was utilized to determine the cross-sectional associations between MEDI-LITE scores and circulating cytokines, bone mineral density, ALM, and ALMBMI. Linear mixed-effects models were performed to estimate associations between MEDI-LITE scores and three-year change in hand grip strength and gait speed while negative binomial regression was applied to estimate associations between MEDI-LITE scores and three-year incident falls as well as associations between each MEDI-LITE component and three-year incident falls. Adjustments for multiple comparisons were performed using Benjamini-Hochberg adjustment for multiple testing.

RESULTS

A higher MEDI-LITE score, indicating greater adherence to Mediterranean diet, was associated with higher appendicular lean mass adjusted for body mass index (ALMBMI) (β: 0.004 kg; 95% CI: 0.000, 0.008), and lower incident falls rates (IRR: 0.94; 95% CI: 0.89, 0.99). Higher consumption of monounsaturated fatty acids (IRR: 0.76; 95% CI: 0.59, 0.98) and monounsaturated fatty acids to saturated fatty acids ratio (IRR: 0.72; 95% CI: 0.57, 0.90) were associated with 24%, and 28% lower falls risk in older men respectively. MEDI-LITE scores were not associated with BMD or physical function parameters.

CONCLUSIONS

Adherence to a Mediterranean diet is associated with higher ALMBMI, and fewer falls in community-dwelling older men. Monounsaturated and saturated fatty acids were the most important contributors to the association between Mediterranean diet and falls risk.

Authors+Show Affiliations

Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia. Electronic address: mavil.cervo@monash.edu.Department of Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, Victoria, Australia; Department of Medicine and Australian Institute of Musculoskeletal Science, Melbourne Medical School-Western Campus, The University of Melbourne, St Albans, Victoria, Australia.Bone Research Program, ANZAC Research Institute, and Department of Endocrinology & Metabolism, Concord Hospital, The University of Sydney, Sydney, New South Wales, Australia.School of Public Health, University of Sydney, Sydney, New South Wales, Australia; Centre for Education and Research on Ageing, Concord Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Ageing and Alzheimer's Institute, Concord Hospital, Sydney, New South Wales, Australia; The ARC Centre of Excellence in Population Ageing Research, University of Sydney, Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Ageing and Alzheimer's Institute, Concord Hospital, Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; Ageing and Alzheimer's Institute, Concord Hospital, Sydney, New South Wales, Australia; The ARC Centre of Excellence in Population Ageing Research, University of Sydney, Sydney, New South Wales, Australia; ANZAC Research Institute & Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.ANZAC Research Institute, University of Sydney, Concord Hospital, Sydney, Australia.School of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia.Centre for Education and Research on Ageing, Concord Hospital, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia; The ARC Centre of Excellence in Population Ageing Research, University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34763260

Citation

Cervo, Mavil May C., et al. "Adherence to Mediterranean Diet and Its Associations With Circulating Cytokines, Musculoskeletal Health and Incident Falls in Community-dwelling Older Men: the Concord Health and Ageing in Men Project." Clinical Nutrition (Edinburgh, Scotland), vol. 40, no. 12, 2021, pp. 5753-5763.
Cervo MMC, Scott D, Seibel MJ, et al. Adherence to Mediterranean diet and its associations with circulating cytokines, musculoskeletal health and incident falls in community-dwelling older men: The Concord Health and Ageing in Men Project. Clin Nutr. 2021;40(12):5753-5763.
Cervo, M. M. C., Scott, D., Seibel, M. J., Cumming, R. G., Naganathan, V., Blyth, F. M., Le Couteur, D. G., Handelsman, D. J., Ribeiro, R. V., Waite, L. M., & Hirani, V. (2021). Adherence to Mediterranean diet and its associations with circulating cytokines, musculoskeletal health and incident falls in community-dwelling older men: The Concord Health and Ageing in Men Project. Clinical Nutrition (Edinburgh, Scotland), 40(12), 5753-5763. https://doi.org/10.1016/j.clnu.2021.10.010
Cervo MMC, et al. Adherence to Mediterranean Diet and Its Associations With Circulating Cytokines, Musculoskeletal Health and Incident Falls in Community-dwelling Older Men: the Concord Health and Ageing in Men Project. Clin Nutr. 2021;40(12):5753-5763. PubMed PMID: 34763260.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adherence to Mediterranean diet and its associations with circulating cytokines, musculoskeletal health and incident falls in community-dwelling older men: The Concord Health and Ageing in Men Project. AU - Cervo,Mavil May C, AU - Scott,David, AU - Seibel,Markus J, AU - Cumming,Robert G, AU - Naganathan,Vasi, AU - Blyth,Fiona M, AU - Le Couteur,David G, AU - Handelsman,David J, AU - Ribeiro,Rosilene V, AU - Waite,Louise M, AU - Hirani,Vasant, Y1 - 2021/10/23/ PY - 2020/05/26/received PY - 2021/10/11/revised PY - 2021/10/14/accepted PY - 2021/11/12/pubmed PY - 2022/2/24/medline PY - 2021/11/11/entrez KW - Appendicular lean mass KW - Bone mineral density KW - Cytokines KW - Falls KW - MEDI-LITE score KW - Mediterranean diet SP - 5753 EP - 5763 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 40 IS - 12 N2 - BACKGROUND & AIMS: Mediterranean dietary patterns may exert favourable effects on various health conditions. This study aimed to determine associations of adherence to Mediterranean diet as well as its components, with circulating cytokine levels, musculoskeletal health and incident falls in community-dwelling older men. METHODS: Seven hundred ninety-four (794) community-dwelling men with mean age 81.1 ± 4.5 years, who participated in the five-year follow-up of the Concord Health and Ageing in Men Project (CHAMP) were included in the cross-sectional analysis, and 616 attended follow-up three years later. Adherence to Mediterranean diet was assessed using MEDI-LITE (literature-derived Mediterranean diet) score which was obtained using a validated diet history questionnaire. Twenty-four evaluable circulating cytokines were analyzed using Bio-Plex Pro Human Cytokine 27-plex Assay kit. Appendicular lean mass (ALM) and bone mineral density (BMD) were measured using dual-energy x-ray absorptiometry (DXA). Three-year changes in gait speed and hand grip strength were assessed by walking a 6-m course and using a dynamometer respectively and analyzed using linear mixed-effects models. Incident falls over three years were determined through telephone interviews every four months. Multivariable linear regression was utilized to determine the cross-sectional associations between MEDI-LITE scores and circulating cytokines, bone mineral density, ALM, and ALMBMI. Linear mixed-effects models were performed to estimate associations between MEDI-LITE scores and three-year change in hand grip strength and gait speed while negative binomial regression was applied to estimate associations between MEDI-LITE scores and three-year incident falls as well as associations between each MEDI-LITE component and three-year incident falls. Adjustments for multiple comparisons were performed using Benjamini-Hochberg adjustment for multiple testing. RESULTS: A higher MEDI-LITE score, indicating greater adherence to Mediterranean diet, was associated with higher appendicular lean mass adjusted for body mass index (ALMBMI) (β: 0.004 kg; 95% CI: 0.000, 0.008), and lower incident falls rates (IRR: 0.94; 95% CI: 0.89, 0.99). Higher consumption of monounsaturated fatty acids (IRR: 0.76; 95% CI: 0.59, 0.98) and monounsaturated fatty acids to saturated fatty acids ratio (IRR: 0.72; 95% CI: 0.57, 0.90) were associated with 24%, and 28% lower falls risk in older men respectively. MEDI-LITE scores were not associated with BMD or physical function parameters. CONCLUSIONS: Adherence to a Mediterranean diet is associated with higher ALMBMI, and fewer falls in community-dwelling older men. Monounsaturated and saturated fatty acids were the most important contributors to the association between Mediterranean diet and falls risk. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/34763260/Adherence_to_Mediterranean_diet_and_its_associations_with_circulating_cytokines_musculoskeletal_health_and_incident_falls_in_community_dwelling_older_men:_The_Concord_Health_and_Ageing_in_Men_Project_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(21)00479-9 DB - PRIME DP - Unbound Medicine ER -