Tags

Type your tag names separated by a space and hit enter

Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer.
JAMA Netw Open. 2021 11 01; 4(11):e2134308.JN

Abstract

Importance

Sulfur-metabolizing bacteria that reduce dietary sulfur to hydrogen sulfide have been associated with colorectal cancer (CRC). However, there are limited studies investigating the association between diet and sulfur-metabolizing bacteria in the development of CRC.

Objective

To develop a dietary score that correlates with gut sulfur-metabolizing bacteria and to examine its association with CRC risk.

Design, Setting, and Participants

This prospective cohort study included data from the Health Professionals Follow-up Study (1986-2014), Nurses' Health Study (1984-2016), and Nurses' Health Study II (1991-2017). Participants were US male health professionals and female registered nurses who were free of inflammatory bowel disease and cancer at baseline, with a subsample of participants who provided stool samples from 2012 to 2014. Statistical analysis was conducted from September 1, 2020, to June 1, 2021.

Exposure

A dietary pattern, assessed by a food-frequency questionnaire, that most correlated with 43 sulfur-metabolizing bacteria identified through taxonomic and functional profiling of gut metagenome data.

Main Outcomes and Measures

Incident CRC.

Results

Among 214 797 participants comprising 46 550 men (mean [SD] age at baseline, 54.3 [9.7] years) and 168 247 women (mean [SD] age at baseline, 43.0 [9.2] years), 3217 incident cases of CRC (1.5%) were documented during 5 278 048 person-years of follow-up. The sulfur microbial diet, developed in a subsample of 307 men (mean [SD] age, 70.5 [4.3] years) and 212 women (mean [SD] age, 61.0 [3.8] years), was characterized by high intakes of low-calorie beverages, french fries, red meats, and processed meats and low intakes of fruits, yellow vegetables, whole grains, legumes, leafy vegetables, and cruciferous vegetables. After adjustment for other risk factors, greater adherence to the sulfur microbial diet was associated with an increased risk of CRC, with a hazard ratio (HR) of 1.27 (95% CI, 1.12-1.44) comparing the highest vs the lowest quintile of the diet score (linear trend of diet score quintiles; P < .001 for trend). When assessed by anatomical subsites, greater adherence to the sulfur microbial diet was positively associated with distal CRC (HR, 1.25; 95% CI, 1.05-1.50; P = .02 for trend) but not proximal colon cancer (HR, 1.13; 95% CI, 0.93-1.39; P = .19 for trend).

Conclusions and Relevance

Adherence to the sulfur microbial diet was associated with an increased risk of CRC, suggesting a potential mediating role of sulfur-metabolizing bacteria in the associaton between diet and CRC. Further research is needed to confirm these findings and to determine the underlying mechanisms.

Authors+Show Affiliations

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston. Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston. Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston. Broad Institute of MIT and Harvard, Cambridge, Massachusetts. Department of Immunology and Infectious Disease, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34767023

Citation

Wang, Yiqing, et al. "Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer." JAMA Network Open, vol. 4, no. 11, 2021, pp. e2134308.
Wang Y, Nguyen LH, Mehta RS, et al. Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer. JAMA Netw Open. 2021;4(11):e2134308.
Wang, Y., Nguyen, L. H., Mehta, R. S., Song, M., Huttenhower, C., & Chan, A. T. (2021). Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer. JAMA Network Open, 4(11), e2134308. https://doi.org/10.1001/jamanetworkopen.2021.34308
Wang Y, et al. Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer. JAMA Netw Open. 2021 11 1;4(11):e2134308. PubMed PMID: 34767023.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association Between the Sulfur Microbial Diet and Risk of Colorectal Cancer. AU - Wang,Yiqing, AU - Nguyen,Long H, AU - Mehta,Raaj S, AU - Song,Mingyang, AU - Huttenhower,Curtis, AU - Chan,Andrew T, Y1 - 2021/11/01/ PY - 2021/11/12/entrez PY - 2021/11/13/pubmed PY - 2022/1/12/medline SP - e2134308 EP - e2134308 JF - JAMA network open JO - JAMA Netw Open VL - 4 IS - 11 N2 - Importance: Sulfur-metabolizing bacteria that reduce dietary sulfur to hydrogen sulfide have been associated with colorectal cancer (CRC). However, there are limited studies investigating the association between diet and sulfur-metabolizing bacteria in the development of CRC. Objective: To develop a dietary score that correlates with gut sulfur-metabolizing bacteria and to examine its association with CRC risk. Design, Setting, and Participants: This prospective cohort study included data from the Health Professionals Follow-up Study (1986-2014), Nurses' Health Study (1984-2016), and Nurses' Health Study II (1991-2017). Participants were US male health professionals and female registered nurses who were free of inflammatory bowel disease and cancer at baseline, with a subsample of participants who provided stool samples from 2012 to 2014. Statistical analysis was conducted from September 1, 2020, to June 1, 2021. Exposure: A dietary pattern, assessed by a food-frequency questionnaire, that most correlated with 43 sulfur-metabolizing bacteria identified through taxonomic and functional profiling of gut metagenome data. Main Outcomes and Measures: Incident CRC. Results: Among 214 797 participants comprising 46 550 men (mean [SD] age at baseline, 54.3 [9.7] years) and 168 247 women (mean [SD] age at baseline, 43.0 [9.2] years), 3217 incident cases of CRC (1.5%) were documented during 5 278 048 person-years of follow-up. The sulfur microbial diet, developed in a subsample of 307 men (mean [SD] age, 70.5 [4.3] years) and 212 women (mean [SD] age, 61.0 [3.8] years), was characterized by high intakes of low-calorie beverages, french fries, red meats, and processed meats and low intakes of fruits, yellow vegetables, whole grains, legumes, leafy vegetables, and cruciferous vegetables. After adjustment for other risk factors, greater adherence to the sulfur microbial diet was associated with an increased risk of CRC, with a hazard ratio (HR) of 1.27 (95% CI, 1.12-1.44) comparing the highest vs the lowest quintile of the diet score (linear trend of diet score quintiles; P < .001 for trend). When assessed by anatomical subsites, greater adherence to the sulfur microbial diet was positively associated with distal CRC (HR, 1.25; 95% CI, 1.05-1.50; P = .02 for trend) but not proximal colon cancer (HR, 1.13; 95% CI, 0.93-1.39; P = .19 for trend). Conclusions and Relevance: Adherence to the sulfur microbial diet was associated with an increased risk of CRC, suggesting a potential mediating role of sulfur-metabolizing bacteria in the associaton between diet and CRC. Further research is needed to confirm these findings and to determine the underlying mechanisms. SN - 2574-3805 UR - https://www.unboundmedicine.com/medline/citation/34767023/Association_Between_the_Sulfur_Microbial_Diet_and_Risk_of_Colorectal_Cancer_ L2 - https://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2021.34308 DB - PRIME DP - Unbound Medicine ER -