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Differential Roles of Water-Insoluble and Water-Soluble Fractions of Diesel Exhaust Particles in the Development of Adverse Health Effects Due to Chronic Instillation of Diesel Exhaust Particles.
Chem Res Toxicol. 2021 12 20; 34(12):2450-2459.CR

Abstract

Ambient fine particulate matter (PM2.5) has a marked temporospatial variation in chemical composition, but how the composition of PM2.5 influences its toxicity remains elusive. To explore the roles of individual PM2.5 components in the pathogenesis following PM2.5 exposure, we prepared water-soluble (WS-DEP) and water-insoluble (WIS-DEP) fractions of diesel exhaust particles (DEP) and performed 15-week intratracheal instillation on C57Bl/6J mice using these fractions. Their effects on pulmonary and systemic inflammation, hepatic steatosis and insulin resistance, systemic glucose homeostasis, and gut microbiota were then assessed. Compared to control, instillation of DEP or WIS-DEP, but not WS-DEP, significantly increased pulmonary inflammatory scores and expression of inflammatory markers, bronchoalveolar lavage fluid cell number, and circulating pro-inflammatory cytokines. Consistently, DEP- or WIS-DEP-instilled but not WS-DEP-instilled mice versus control had significant hepatic steatosis and insulin resistance and systemic glucose intolerance. In contrast, instillation of WS-DEP versus instillation of WIS-DEP had effects on the gut microbiota more comparable to that of instillations of DEP. The pulmonary and systemic inflammation, hepatic steatosis and insulin resistance, and systemic glucose intolerance following chronic DEP instillation are all attributable to the WIS-DEP, suggesting that PM2.5 may have a solubility-dependent basal toxicity.

Authors+Show Affiliations

Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.National Clinical Research Center for Interventional Medicine, Shanghai 200032, China.Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland 21202, United States.Department of Environmental Health, School of Public Health, Fudan University, Shanghai 200032, China.Department of Medicine Cardiology Division, University of Maryland School of Medicine, Baltimore, Maryland 21202, United States.National Clinical Research Center for Interventional Medicine, Shanghai 200032, China. Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34780166

Citation

Xu, Yanyi, et al. "Differential Roles of Water-Insoluble and Water-Soluble Fractions of Diesel Exhaust Particles in the Development of Adverse Health Effects Due to Chronic Instillation of Diesel Exhaust Particles." Chemical Research in Toxicology, vol. 34, no. 12, 2021, pp. 2450-2459.
Xu Y, Li Z, Liu Y, et al. Differential Roles of Water-Insoluble and Water-Soluble Fractions of Diesel Exhaust Particles in the Development of Adverse Health Effects Due to Chronic Instillation of Diesel Exhaust Particles. Chem Res Toxicol. 2021;34(12):2450-2459.
Xu, Y., Li, Z., Liu, Y., Pan, B., Peng, R., Shao, W., Yang, W., Chen, M., Kan, H., Ying, Z., & Zhang, Y. (2021). Differential Roles of Water-Insoluble and Water-Soluble Fractions of Diesel Exhaust Particles in the Development of Adverse Health Effects Due to Chronic Instillation of Diesel Exhaust Particles. Chemical Research in Toxicology, 34(12), 2450-2459. https://doi.org/10.1021/acs.chemrestox.1c00199
Xu Y, et al. Differential Roles of Water-Insoluble and Water-Soluble Fractions of Diesel Exhaust Particles in the Development of Adverse Health Effects Due to Chronic Instillation of Diesel Exhaust Particles. Chem Res Toxicol. 2021 12 20;34(12):2450-2459. PubMed PMID: 34780166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differential Roles of Water-Insoluble and Water-Soluble Fractions of Diesel Exhaust Particles in the Development of Adverse Health Effects Due to Chronic Instillation of Diesel Exhaust Particles. AU - Xu,Yanyi, AU - Li,Zhouzhou, AU - Liu,Ying, AU - Pan,Bin, AU - Peng,Renzheng, AU - Shao,Wenpu, AU - Yang,Wenhui, AU - Chen,Minjie, AU - Kan,Haidong, AU - Ying,Zhekang, AU - Zhang,Yuhao, Y1 - 2021/11/15/ PY - 2021/11/16/pubmed PY - 2022/1/19/medline PY - 2021/11/15/entrez SP - 2450 EP - 2459 JF - Chemical research in toxicology JO - Chem Res Toxicol VL - 34 IS - 12 N2 - Ambient fine particulate matter (PM2.5) has a marked temporospatial variation in chemical composition, but how the composition of PM2.5 influences its toxicity remains elusive. To explore the roles of individual PM2.5 components in the pathogenesis following PM2.5 exposure, we prepared water-soluble (WS-DEP) and water-insoluble (WIS-DEP) fractions of diesel exhaust particles (DEP) and performed 15-week intratracheal instillation on C57Bl/6J mice using these fractions. Their effects on pulmonary and systemic inflammation, hepatic steatosis and insulin resistance, systemic glucose homeostasis, and gut microbiota were then assessed. Compared to control, instillation of DEP or WIS-DEP, but not WS-DEP, significantly increased pulmonary inflammatory scores and expression of inflammatory markers, bronchoalveolar lavage fluid cell number, and circulating pro-inflammatory cytokines. Consistently, DEP- or WIS-DEP-instilled but not WS-DEP-instilled mice versus control had significant hepatic steatosis and insulin resistance and systemic glucose intolerance. In contrast, instillation of WS-DEP versus instillation of WIS-DEP had effects on the gut microbiota more comparable to that of instillations of DEP. The pulmonary and systemic inflammation, hepatic steatosis and insulin resistance, and systemic glucose intolerance following chronic DEP instillation are all attributable to the WIS-DEP, suggesting that PM2.5 may have a solubility-dependent basal toxicity. SN - 1520-5010 UR - https://www.unboundmedicine.com/medline/citation/34780166/Differential_Roles_of_Water_Insoluble_and_Water_Soluble_Fractions_of_Diesel_Exhaust_Particles_in_the_Development_of_Adverse_Health_Effects_Due_to_Chronic_Instillation_of_Diesel_Exhaust_Particles_ L2 - https://doi.org/10.1021/acs.chemrestox.1c00199 DB - PRIME DP - Unbound Medicine ER -