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Can contingency rehearsal during the interval between a retrieval cue and extinction training change the effects of post-retrieval extinction?
Psychophysiology. 2022 03; 59(3):e13971.P

Abstract

Return of fear may be prevented by post-retrieval extinction (PRE), a procedure consisting of presenting a stimulus that was present during conditioning (retrieval cue) prior to extinction training. However, recent evidence suggests that there might be circumstances under which PRE is not effective to prevent the return of fear (boundary conditions), but some of these conditions remain unknown. We explored if rehearsing the CS, US or CS-US contingency during the interval between the retrieval cue and extinction training might change the effects of PRE. One day after differential fear conditioning, healthy human participants (n = 83) underwent either standard extinction (control condition, n = 31) or two different PRE procedures, one in which participants rehearsed the CS-US contingency during the interval between the retrieval cue and extinction (rehearsal condition, n = 25), or another in which they underwent a verbal fluency task directing their attention away from the experimental contingencies during this interval (nonrehearsal condition, n = 27). Return of fear in a reinstatement test was observed in both control and rehearsal conditions, whereas in the nonrehearsal condition there was a generalized increase in response to the CS+ and CS-. Differential response in the rehearsal condition had values slightly smaller than the control group with no significant differences from both control and nonrehearsal conditions. These results suggest that the overt behavior of participants during the interval between a retrieval cue and extinction training might change the effects of PRE in healthy human participants, but further manipulations of these variables are needed to confirm these findings.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Zuccolo PF
Institute of Psychology, Department of Experimental Psychology, University of São Paulo, São Paulo, Brazil.
Hunziker MHL
Institute of Psychology, Department of Experimental Psychology, University of São Paulo, São Paulo, Brazil.

MeSH

AdultConditioning, ClassicalCuesExtinction, PsychologicalFearFemaleHumansMaleYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

34792802

Citation

Zuccolo, Pedro Fonseca, and Maria Helena Leite Hunziker. "Can Contingency Rehearsal During the Interval Between a Retrieval Cue and Extinction Training Change the Effects of Post-retrieval Extinction?" Psychophysiology, vol. 59, no. 3, 2022, pp. e13971.
Zuccolo PF, Hunziker MHL. Can contingency rehearsal during the interval between a retrieval cue and extinction training change the effects of post-retrieval extinction? Psychophysiology. 2022;59(3):e13971.
Zuccolo, P. F., & Hunziker, M. H. L. (2022). Can contingency rehearsal during the interval between a retrieval cue and extinction training change the effects of post-retrieval extinction? Psychophysiology, 59(3), e13971. https://doi.org/10.1111/psyp.13971
Zuccolo PF, Hunziker MHL. Can Contingency Rehearsal During the Interval Between a Retrieval Cue and Extinction Training Change the Effects of Post-retrieval Extinction. Psychophysiology. 2022;59(3):e13971. PubMed PMID: 34792802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can contingency rehearsal during the interval between a retrieval cue and extinction training change the effects of post-retrieval extinction? AU - Zuccolo,Pedro Fonseca, AU - Hunziker,Maria Helena Leite, Y1 - 2021/11/18/ PY - 2021/08/23/revised PY - 2020/06/10/received PY - 2021/11/03/accepted PY - 2021/11/19/pubmed PY - 2022/2/25/medline PY - 2021/11/18/entrez KW - EDA KW - post-retrieval extinction KW - reconsolidation KW - rehearsal KW - return of fear KW - skin conductance SP - e13971 EP - e13971 JF - Psychophysiology JO - Psychophysiology VL - 59 IS - 3 N2 - Return of fear may be prevented by post-retrieval extinction (PRE), a procedure consisting of presenting a stimulus that was present during conditioning (retrieval cue) prior to extinction training. However, recent evidence suggests that there might be circumstances under which PRE is not effective to prevent the return of fear (boundary conditions), but some of these conditions remain unknown. We explored if rehearsing the CS, US or CS-US contingency during the interval between the retrieval cue and extinction training might change the effects of PRE. One day after differential fear conditioning, healthy human participants (n = 83) underwent either standard extinction (control condition, n = 31) or two different PRE procedures, one in which participants rehearsed the CS-US contingency during the interval between the retrieval cue and extinction (rehearsal condition, n = 25), or another in which they underwent a verbal fluency task directing their attention away from the experimental contingencies during this interval (nonrehearsal condition, n = 27). Return of fear in a reinstatement test was observed in both control and rehearsal conditions, whereas in the nonrehearsal condition there was a generalized increase in response to the CS+ and CS-. Differential response in the rehearsal condition had values slightly smaller than the control group with no significant differences from both control and nonrehearsal conditions. These results suggest that the overt behavior of participants during the interval between a retrieval cue and extinction training might change the effects of PRE in healthy human participants, but further manipulations of these variables are needed to confirm these findings. SN - 1540-5958 UR - https://www.unboundmedicine.com/medline/citation/34792802/Can_contingency_rehearsal_during_the_interval_between_a_retrieval_cue_and_extinction_training_change_the_effects_of_post_retrieval_extinction DB - PRIME DP - Unbound Medicine ER -