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Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococci.
Antimicrob Agents Chemother 1987; 31(10):1549-52AA

Abstract

The activity of CGP 31608 for 53 strains of Staphylococcus aureus and 48 strains of S. epidermidis, both methicillin susceptible and resistant, was compared with that of vancomycin, nafcillin, cefamandole, and imipenem. Microdilution MICs were determined in Mueller-Hinton broth with or without 2.5% NaCl at an inoculum of 3 x 10(5) CFU/ml with a 20-h, 37 degrees C incubation. The MICs of imipenem and CGP 31608 for methicillin-resistant strains were lower than the MICs of nafcillin or cefamandole for these strains; these differences diminished in the presence of 2.5% NaCl. Subpopulations were detected in strains of methicillin-resistant S. aureus and S. epidermidis that were resistant to all the beta-lactam antibiotics tested at 5 micrograms/ml. This resistant subpopulation produced progeny that were uniformly resistant to high concentrations of each of the beta-lactams.

Authors+Show Affiliations

Medical Service, San Francisco General Hospital, California 94110.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

3481245

Citation

Sachdeva, M, et al. "Comparative Activity of CGP 31608, Nafcillin, Cefamandole, Imipenem, and Vancomycin Against Methicillin-susceptible and Methicillin-resistant Staphylococci." Antimicrobial Agents and Chemotherapy, vol. 31, no. 10, 1987, pp. 1549-52.
Sachdeva M, Hackbarth C, Stella FB, et al. Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococci. Antimicrob Agents Chemother. 1987;31(10):1549-52.
Sachdeva, M., Hackbarth, C., Stella, F. B., & Chambers, H. F. (1987). Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococci. Antimicrobial Agents and Chemotherapy, 31(10), pp. 1549-52.
Sachdeva M, et al. Comparative Activity of CGP 31608, Nafcillin, Cefamandole, Imipenem, and Vancomycin Against Methicillin-susceptible and Methicillin-resistant Staphylococci. Antimicrob Agents Chemother. 1987;31(10):1549-52. PubMed PMID: 3481245.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative activity of CGP 31608, nafcillin, cefamandole, imipenem, and vancomycin against methicillin-susceptible and methicillin-resistant staphylococci. AU - Sachdeva,M, AU - Hackbarth,C, AU - Stella,F B, AU - Chambers,H F, PY - 1987/10/1/pubmed PY - 1987/10/1/medline PY - 1987/10/1/entrez SP - 1549 EP - 52 JF - Antimicrobial agents and chemotherapy JO - Antimicrob. Agents Chemother. VL - 31 IS - 10 N2 - The activity of CGP 31608 for 53 strains of Staphylococcus aureus and 48 strains of S. epidermidis, both methicillin susceptible and resistant, was compared with that of vancomycin, nafcillin, cefamandole, and imipenem. Microdilution MICs were determined in Mueller-Hinton broth with or without 2.5% NaCl at an inoculum of 3 x 10(5) CFU/ml with a 20-h, 37 degrees C incubation. The MICs of imipenem and CGP 31608 for methicillin-resistant strains were lower than the MICs of nafcillin or cefamandole for these strains; these differences diminished in the presence of 2.5% NaCl. Subpopulations were detected in strains of methicillin-resistant S. aureus and S. epidermidis that were resistant to all the beta-lactam antibiotics tested at 5 micrograms/ml. This resistant subpopulation produced progeny that were uniformly resistant to high concentrations of each of the beta-lactams. SN - 0066-4804 UR - https://www.unboundmedicine.com/medline/citation/3481245/Comparative_activity_of_CGP_31608_nafcillin_cefamandole_imipenem_and_vancomycin_against_methicillin_susceptible_and_methicillin_resistant_staphylococci_ L2 - http://aac.asm.org/cgi/pmidlookup?view=long&pmid=3481245 DB - PRIME DP - Unbound Medicine ER -