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Acute toxicity of polychlorinated diphenyl ethers (PCDEs) in three model aquatic organisms (Scenedesmus obliquus, Daphnia magna, and Danio rerio) of different trophic levels.
Sci Total Environ. 2022 Jan 20; 805:150366.ST

Abstract

The frequent detection of polychlorinated diphenyl ethers (PCDEs) in aquatic systems has aroused widespread concerns, however, their potential hazard to aquatic ecosystems has been poorly understood. Here the acute toxicity of 12 PCDE congeners was evaluated in three model aquatic organisms representing different trophic levels following OECD test guidelines, including green algae (Scenedesmus obliquus), water flea (Daphnia magna), and zebrafish (Danio rerio). Dose-dependent increases in growth inhibition and mortality were observed for all tested PCDE congeners. Most of the PCDE congeners, in particular 3,3',4,4'-tetra-CDE, were highly toxic to the three aquatic organisms with EC50 or LC50 values below 1 mg L-1. Their toxicities were generally comparable with those of certain polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). Moreover, D. magna was the most sensitive species among the three aquatic organisms. In addition, the EC50 or LC50 values had an extremely significant correlation with the n-octanol-water partition coefficient (logKow) of the PCDE congeners. The established quantitative structure-property relationship (QSPR) models indicated that the molecular polarizability (α) could significantly influence the acute toxicity of PCDEs on Daphnia magna and Danio rerio, and the energy of the lowest unoccupied molecular orbital (ELUMO) is the key factor of the acute toxicity of PCDEs in Scenedesmus obliquus. In addition, even at environmental levels, 3,3',4,4'-tetra-CDE could induced seveve oxidative damages in the three aquactic species. These findings would contribute to the understanding of adverse effects of PCDEs in aquatic organisms.

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Authors+Show Affiliations

Yang W
School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China; Laboratory of Wetland Protection and Ecological Restoration, Anhui University, Hefei 230601, Anhui, China.
Huang X
School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China; Laboratory of Wetland Protection and Ecological Restoration, Anhui University, Hefei 230601, Anhui, China.
Wu Q
School of Water Conservancy and Environment, University of Jinan, Jinan 100085, China.
Shi J
Nanjing Institute of Environmental Sciences of the Ministry of Ecology and Environment, Nanjing 210042, Jiangsu, China.
Zhang X
School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China; Laboratory of Wetland Protection and Ecological Restoration, Anhui University, Hefei 230601, Anhui, China. Electronic address: zhangqing8725@163.com.
Ouyang L
School of Resources and Environmental Engineering, Anhui University, Hefei 230601, Anhui, China; Laboratory of Wetland Protection and Ecological Restoration, Anhui University, Hefei 230601, Anhui, China.
Crump D
Ecotoxicology and Wildlife Health Division, Environment and Climate Change Canada, National Wildlife Research Centre, Carleton University, 1125 Colonel By Drive, Ottawa K1A 0H3, Canada.
Zhang X
State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
Zhang R
School of Water Conservancy and Environment, University of Jinan, Jinan 100085, China. Electronic address: stu_zhangr@ujn.edu.cn.

MeSH

AnimalsAquatic OrganismsDaphniaEcosystemHalogenated Diphenyl EthersScenedesmusWater Pollutants, ChemicalZebrafish

Pub Type(s)

Journal Article

Language

eng

PubMed ID

34818752

Citation

Yang, Wenhui, et al. "Acute Toxicity of Polychlorinated Diphenyl Ethers (PCDEs) in Three Model Aquatic Organisms (Scenedesmus Obliquus, Daphnia Magna, and Danio Rerio) of Different Trophic Levels." The Science of the Total Environment, vol. 805, 2022, p. 150366.
Yang W, Huang X, Wu Q, et al. Acute toxicity of polychlorinated diphenyl ethers (PCDEs) in three model aquatic organisms (Scenedesmus obliquus, Daphnia magna, and Danio rerio) of different trophic levels. Sci Total Environ. 2022;805:150366.
Yang, W., Huang, X., Wu, Q., Shi, J., Zhang, X., Ouyang, L., Crump, D., Zhang, X., & Zhang, R. (2022). Acute toxicity of polychlorinated diphenyl ethers (PCDEs) in three model aquatic organisms (Scenedesmus obliquus, Daphnia magna, and Danio rerio) of different trophic levels. The Science of the Total Environment, 805, 150366. https://doi.org/10.1016/j.scitotenv.2021.150366
Yang W, et al. Acute Toxicity of Polychlorinated Diphenyl Ethers (PCDEs) in Three Model Aquatic Organisms (Scenedesmus Obliquus, Daphnia Magna, and Danio Rerio) of Different Trophic Levels. Sci Total Environ. 2022 Jan 20;805:150366. PubMed PMID: 34818752.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acute toxicity of polychlorinated diphenyl ethers (PCDEs) in three model aquatic organisms (Scenedesmus obliquus, Daphnia magna, and Danio rerio) of different trophic levels. AU - Yang,Wenhui, AU - Huang,Xinxin, AU - Wu,Qiuxuan, AU - Shi,Jiaqi, AU - Zhang,Xuesheng, AU - Ouyang,Lingwen, AU - Crump,Doug, AU - Zhang,Xiaowei, AU - Zhang,Rui, Y1 - 2021/09/17/ PY - 2021/06/06/received PY - 2021/09/07/revised PY - 2021/09/12/accepted PY - 2021/11/25/entrez PY - 2021/11/26/pubmed PY - 2021/11/27/medline KW - Acute toxicity KW - Aquatic organisms KW - Oxidative stress KW - Polychlorinated diphenyl ethers KW - Quantitative structure-property relationship SP - 150366 EP - 150366 JF - The Science of the total environment JO - Sci Total Environ VL - 805 N2 - The frequent detection of polychlorinated diphenyl ethers (PCDEs) in aquatic systems has aroused widespread concerns, however, their potential hazard to aquatic ecosystems has been poorly understood. Here the acute toxicity of 12 PCDE congeners was evaluated in three model aquatic organisms representing different trophic levels following OECD test guidelines, including green algae (Scenedesmus obliquus), water flea (Daphnia magna), and zebrafish (Danio rerio). Dose-dependent increases in growth inhibition and mortality were observed for all tested PCDE congeners. Most of the PCDE congeners, in particular 3,3',4,4'-tetra-CDE, were highly toxic to the three aquatic organisms with EC50 or LC50 values below 1 mg L-1. Their toxicities were generally comparable with those of certain polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs). Moreover, D. magna was the most sensitive species among the three aquatic organisms. In addition, the EC50 or LC50 values had an extremely significant correlation with the n-octanol-water partition coefficient (logKow) of the PCDE congeners. The established quantitative structure-property relationship (QSPR) models indicated that the molecular polarizability (α) could significantly influence the acute toxicity of PCDEs on Daphnia magna and Danio rerio, and the energy of the lowest unoccupied molecular orbital (ELUMO) is the key factor of the acute toxicity of PCDEs in Scenedesmus obliquus. In addition, even at environmental levels, 3,3',4,4'-tetra-CDE could induced seveve oxidative damages in the three aquactic species. These findings would contribute to the understanding of adverse effects of PCDEs in aquatic organisms. SN - 1879-1026 UR - https://www.unboundmedicine.com/medline/citation/34818752/Acute_toxicity_of_polychlorinated_diphenyl_ethers__PCDEs__in_three_model_aquatic_organisms__Scenedesmus_obliquus_Daphnia_magna_and_Danio_rerio__of_different_trophic_levels_ DB - PRIME DP - Unbound Medicine ER -