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Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy.
Cells. 2021 10 25; 10(11)C

Abstract

As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases.

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Authors+Show Affiliations

Bhalerao A
Department of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USA.
Raut S
Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.
Noorani B
Department of Pharmaceutical Sciences, Jerry H. Hodge School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA.
Mancuso S
Department of Biological and Biomedical Sciences, Oakland University, Rochester, MI 48309, USA.
Cucullo L
Department of Foundational Medical Studies, Oakland University William Beaumont School of Medicine, Rochester, MI 48309, USA.

MeSH

COVID-19Clinical Trials as TopicCytokine Release SyndromeHumansImmunomodulationMultiple Organ FailureRegenerative MedicineSARS-CoV-2Stem Cell TransplantationStem Cells

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

34831101

Citation

Bhalerao, Aditya, et al. "Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy." Cells, vol. 10, no. 11, 2021.
Bhalerao A, Raut S, Noorani B, et al. Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy. Cells. 2021;10(11).
Bhalerao, A., Raut, S., Noorani, B., Mancuso, S., & Cucullo, L. (2021). Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy. Cells, 10(11). https://doi.org/10.3390/cells10112878
Bhalerao A, et al. Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy. Cells. 2021 10 25;10(11) PubMed PMID: 34831101.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular Mechanisms of Multi-Organ Failure in COVID-19 and Potential of Stem Cell Therapy. AU - Bhalerao,Aditya, AU - Raut,Snehal, AU - Noorani,Behnam, AU - Mancuso,Salvatore, AU - Cucullo,Luca, Y1 - 2021/10/25/ PY - 2021/09/16/received PY - 2021/10/18/revised PY - 2021/10/22/accepted PY - 2021/11/27/entrez PY - 2021/11/28/pubmed PY - 2021/12/15/medline KW - COVID-19 KW - SARS-CoV-2 KW - blood-brain-barrier KW - mesenchymal KW - oxidative stress KW - regenerative KW - stem cells KW - therapeutics JF - Cells JO - Cells VL - 10 IS - 11 N2 - As the number of confirmed cases and deaths occurring from Coronavirus disease 2019 (COVID-19) surges worldwide, health experts are striving hard to fully comprehend the extent of damage caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although COVID-19 primarily manifests itself in the form of severe respiratory distress, it is also known to cause systemic damage to almost all major organs and organ systems within the body. In this review, we discuss the molecular mechanisms leading to multi-organ failure seen in COVID-19 patients. We also examine the potential of stem cell therapy in treating COVID-19 multi-organ failure cases. SN - 2073-4409 UR - https://www.unboundmedicine.com/medline/citation/34831101/Molecular_Mechanisms_of_Multi_Organ_Failure_in_COVID_19_and_Potential_of_Stem_Cell_Therapy_ DB - PRIME DP - Unbound Medicine ER -