TY - JOUR T1 - Interspecies Jumping of Bat Coronaviruses. AU - Wong,Antonio C P, AU - Lau,Susanna K P, AU - Woo,Patrick C Y, Y1 - 2021/10/29/ PY - 2021/10/11/received PY - 2021/10/27/revised PY - 2021/10/28/accepted PY - 2021/11/27/entrez PY - 2021/11/28/pubmed PY - 2021/12/15/medline KW - COVID-19 KW - MERS KW - SADS KW - SARS KW - bat KW - coronavirus KW - epidemic KW - interspecies jumping KW - outbreak KW - pandemic JF - Viruses JO - Viruses VL - 13 IS - 11 N2 - In the last two decades, several coronavirus (CoV) interspecies jumping events have occurred between bats and other animals/humans, leading to major epidemics/pandemics and high fatalities. The SARS epidemic in 2002/2003 had a ~10% fatality. The discovery of SARS-related CoVs in horseshoe bats and civets and genomic studies have confirmed bat-to-civet-to-human transmission. The MERS epidemic that emerged in 2012 had a ~35% mortality, with dromedaries as the reservoir. Although CoVs with the same genome organization (e.g., Tylonycteris BatCoV HKU4 and Pipistrellus BatCoV HKU5) were also detected in bats, there is still a phylogenetic gap between these bat CoVs and MERS-CoV. In 2016, 10 years after the discovery of Rhinolophus BatCoV HKU2 in Chinese horseshoe bats, fatal swine disease outbreaks caused by this virus were reported in southern China. In late 2019, an outbreak of pneumonia emerged in Wuhan, China, and rapidly spread globally, leading to >4,000,000 fatalities so far. Although the genome of SARS-CoV-2 is highly similar to that of SARS-CoV, patient zero and the original source of the pandemic are still unknown. To protect humans from future public health threats, measures should be taken to monitor and reduce the chance of interspecies jumping events, either occurring naturally or through recombineering experiments. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/34834994/Interspecies_Jumping_of_Bat_Coronaviruses_ DB - PRIME DP - Unbound Medicine ER -