Tags

Type your tag names separated by a space and hit enter

Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer.
Cancer Cell. 2022 01 10; 40(1):3-5.CC

Abstract

Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy.

Authors+Show Affiliations

Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Division of Infectious Diseases, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Pediatrics, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.Department of Pathology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA.The Leukemia & Lymphoma Society, Rye Brook, NY, USA.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: amit.verma@einsteinmed.org.Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: bahalmos@montefiore.org.

Pub Type(s)

Letter
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

34838186

Citation

Shapiro, Lauren C., et al. "Efficacy of Booster Doses in Augmenting Waning Immune Responses to COVID-19 Vaccine in Patients With Cancer." Cancer Cell, vol. 40, no. 1, 2022, pp. 3-5.
Shapiro LC, Thakkar A, Campbell ST, et al. Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer. Cancer Cell. 2022;40(1):3-5.
Shapiro, L. C., Thakkar, A., Campbell, S. T., Forest, S. K., Pradhan, K., Gonzalez-Lugo, J. D., Quinn, R., Bhagat, T. D., Choudhary, G. S., McCort, M., Sica, R. A., Goldfinger, M., Goel, S., Anampa, J. D., Levitz, D., Fromowitz, A., Shah, A. P., Sklow, C., Alfieri, G., ... Halmos, B. (2022). Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer. Cancer Cell, 40(1), 3-5. https://doi.org/10.1016/j.ccell.2021.11.006
Shapiro LC, et al. Efficacy of Booster Doses in Augmenting Waning Immune Responses to COVID-19 Vaccine in Patients With Cancer. Cancer Cell. 2022 01 10;40(1):3-5. PubMed PMID: 34838186.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of booster doses in augmenting waning immune responses to COVID-19 vaccine in patients with cancer. AU - Shapiro,Lauren C, AU - Thakkar,Astha, AU - Campbell,Sean T, AU - Forest,Stefanie K, AU - Pradhan,Kith, AU - Gonzalez-Lugo,Jesus D, AU - Quinn,Ryann, AU - Bhagat,Tushar D, AU - Choudhary,Gaurav S, AU - McCort,Margaret, AU - Sica,R Alejandro, AU - Goldfinger,Mendel, AU - Goel,Swati, AU - Anampa,Jesus D, AU - Levitz,David, AU - Fromowitz,Ariel, AU - Shah,Akash Pradip, AU - Sklow,Charlotte, AU - Alfieri,Gregory, AU - Racine,Andrew, AU - Wolgast,Lucia, AU - Greenberger,Lee, AU - Verma,Amit, AU - Halmos,Balazs, Y1 - 2021/11/16/ PY - 2021/11/29/pubmed PY - 2022/1/20/medline PY - 2021/11/28/entrez SP - 3 EP - 5 JF - Cancer cell JO - Cancer Cell VL - 40 IS - 1 N2 - Anti-COVID-19 immunity dynamics were assessed in patients with cancer in a prospective clinical trial. Waning of immunity was detected 4-6 months post-vaccination with significant increases in anti-spike IgG titers after booster dosing, and 56% of seronegative patients seroconverted post-booster vaccination. Prior anti-CD20/BTK inhibitor therapy was associated with reduced vaccine efficacy. SN - 1878-3686 UR - https://www.unboundmedicine.com/medline/citation/34838186/Efficacy_of_booster_doses_in_augmenting_waning_immune_responses_to_COVID_19_vaccine_in_patients_with_cancer_ DB - PRIME DP - Unbound Medicine ER -