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The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19.
Biomed Res Int. 2021; 2021:3178796.BR

Abstract

The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seriously affected public health and social stability. The main route of the transmission is droplet transmission, where the oral cavity is the most important entry point to the body. Due to both the direct harmful effects of SARS-CoV-2 and disordered immune responses, some COVID-19 patients may progress to acute respiratory distress syndrome or even multiple organ failure. Genetic variants of SARS-CoV-2 have been emerging and circulating around the world. Currently, there is no internationally approved precise treatment for COVID-19. Mesenchymal stem cells (MSCs) can traffic and migrate towards the affected tissue, regulate both the innate and acquired immune systems, and participate in the process of healing. Here, we will discuss and investigate the mechanisms of immune disorder in COVID-19 and the therapeutic activity of MSCs, in particular human gingiva mesenchymal stem cells.

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Authors+Show Affiliations

Li X
Key Laboratory of Biotherapy and Regenerative Medicine, Lanzhou, 730000 Gansu, China. The First Clinical Medical College, Lanzhou University, Lanzhou, 730000 Gansu, China. Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, Lanzhou, China.
Yan M
The First Clinical Medical College, Lanzhou University, Lanzhou, 730000 Gansu, China.
Chen J
The Department of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000 Gansu, China.
Luo Y
Key Laboratory of Biotherapy and Regenerative Medicine, Lanzhou, 730000 Gansu, China. The Department of Neurology, The First Hospital of Lanzhou University, Lanzhou, 730000 Gansu, China.

MeSH

COVID-19Cytokine Release SyndromeGenetic VariationGingivaHumansMesenchymal Stem Cell TransplantationSARS-CoV-2

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

34840969

Citation

Li, Xun, et al. "The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm Due to COVID-19." BioMed Research International, vol. 2021, 2021, p. 3178796.
Li X, Yan M, Chen J, et al. The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19. Biomed Res Int. 2021;2021:3178796.
Li, X., Yan, M., Chen, J., & Luo, Y. (2021). The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19. BioMed Research International, 2021, 3178796. https://doi.org/10.1155/2021/3178796
Li X, et al. The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm Due to COVID-19. Biomed Res Int. 2021;2021:3178796. PubMed PMID: 34840969.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Potential of Mesenchymal Stem Cells for the Treatment of Cytokine Storm due to COVID-19. AU - Li,Xun, AU - Yan,Mengchao, AU - Chen,Jun, AU - Luo,Yang, Y1 - 2021/11/26/ PY - 2021/08/22/received PY - 2021/10/24/revised PY - 2021/10/29/accepted PY - 2021/11/29/entrez PY - 2021/11/30/pubmed PY - 2021/12/15/medline SP - 3178796 EP - 3178796 JF - BioMed research international JO - Biomed Res Int VL - 2021 N2 - The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has seriously affected public health and social stability. The main route of the transmission is droplet transmission, where the oral cavity is the most important entry point to the body. Due to both the direct harmful effects of SARS-CoV-2 and disordered immune responses, some COVID-19 patients may progress to acute respiratory distress syndrome or even multiple organ failure. Genetic variants of SARS-CoV-2 have been emerging and circulating around the world. Currently, there is no internationally approved precise treatment for COVID-19. Mesenchymal stem cells (MSCs) can traffic and migrate towards the affected tissue, regulate both the innate and acquired immune systems, and participate in the process of healing. Here, we will discuss and investigate the mechanisms of immune disorder in COVID-19 and the therapeutic activity of MSCs, in particular human gingiva mesenchymal stem cells. SN - 2314-6141 UR - https://www.unboundmedicine.com/medline/citation/34840969/The_Potential_of_Mesenchymal_Stem_Cells_for_the_Treatment_of_Cytokine_Storm_due_to_COVID_19_ DB - PRIME DP - Unbound Medicine ER -